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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan
Taufiq Siregar, Mara Imam
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Medicine & Pharmacology

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Journal : Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan

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Mekanisme Resistensi Isoniazid &Mutasi Gen KatG Ser315Thr (G944C) Mycobacterium tuberculosis Sebagai Penyebab TerseringResistensi Isoniazid Taufiq Siregar, Mara Imam
JAMBI MEDICAL JOURNAL "Jurnal Kedokteran dan Kesehatan" Vol. 3 No. 2 (2015): JAMBI MEDICAL JOURNAL Jurnal Kedokteran dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (889.211 KB) | DOI: 10.22437/jmj.v3i2.3088

Abstract

ABSTRACT Resistance to anti-tuberculosis drugs mainly occurs due to a mutation in the genes of Mycobacterium tuberculosis. Mutations can be induced by inadequate therapeutic levels of drug, mainly due to non-compliance for taking the drug. Therefore, the use of anti-tuberculosis drugs inappropriately and irregularly can lead to mutation in the gene encoding the target of anti-tuberculosis drugs. Inadequate therapeutic levels of drug due to non-compliance of patients taking isoniazid was the most frequent causing mutations in  KatG (Ser315Thr) gene. Therefore, concluded that this mutation was the commonest cause of INH resistance and could be a potential genetic marker for predicting MDR-TB. 
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