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All Journal Jurnal Ilmiah Farmasi Dimas: Jurnal Pemikiran Agama untuk Pemberdayaan MPI (Media Pharmaceutica Indonesiana) Jurnal IPA Terpadu MUHARRIK: JURNAL DAKWAH DAN SOSIAL JFIOnline Jurnal Ilmu Kefarmasian Indonesia Proceedings of Annual Conference for Muslim Scholars Jurnal Aisyah : Jurnal Ilmu Kesehatan Indonesian Journal of Global Health research Chemistry and Materials Pharmaceutical Sciences and Research (PSR) Al-Istinbath: Jurnal Hukum Islam Jurnal Farmasi Indonesia Jurnal Penelitian dan Pengabdian Masyarakat Multidisciplinary Journal of Education, Economic and Culture Miftah Journal of Islamic Education
Mun'im, Abdul
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Journal : Jurnal Aisyah : Jurnal Ilmu Kesehatan

 1 
Memory Loss induced by Aspartame in Albino Rats: Study on neurobehavioral changes Suswidiantoro, Vicko; Saputri, Fadlina Chany; Mun'im, Abdul
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 6, No 2: June 2021
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1377.637 KB) | DOI: 10.30604/jika.v6i2.511

Abstract

Objective: Aspartame (ASP) consumption in various food and beverage products has generated a lot of controversy on safety. Many reports, ASP caused deterioration of health condition likes diabetes, psychiatric disorders, memory loss, etc. This study aimed to investigate the optimization duration of ASP to induce memory loss in Sprague Dawley rats. Methods: The ASP was administered 40 mg/kg BW orally for 28 days in rats. Analysis of memory loss by neurobehavioural changes including latency time, length of track, per cent time and frequency target quadrant using Morris Water Maze (MWM) at day 14, 21, 28, and 24 hours after the last treatment. Results: The administration of ASP showed the time-dependent changes for each indicator of neurobehavioural. The results demonstrated during 28 days of induction showed a significant decrease in latency time, length of track, per cent time and frequency target quadrant. Conclusion: From the results, it can be concluded administration of ASP during 28 days induce neurobehavioural changes related to memory loss in rats.  Abstrak: Objektif: Penggunaan aspartame (ASP) sebagai pemanis buatan yang banyak terdapat pada makanan, dan minuman menimbulkan berbagai kontroversi dalam hal keamanan. Berbagai data menunjukkan ASP dapat menyebabkan gangguan kesehatan seperti diabetes, gangguan psikiatrik, penurunan fungsi memori, dll. Penelitian ini bertujuan untuk menentukan waktu durasi penggunaan ASP yang dapat menyebabkan gangguan fungsi memori pada tikus Sprague Dawley. Metode:ASP diberikan secara oral pada tikus dengan dosis 40 mg/kg BB selama 28 hari. Analisis terhadap fungsi memori dilakukan dengan adanya perubahan perilaku pada hewan, meliputi waktu latensi, Panjang lintasan, persentase waktu dan frekuensi kuadran menggunakan Morris Water Maze (MWM) setelah 24 jam setelah pemberian pada hari ke 14,21, 28. Hasil: Pemberian ASP menunjukkan adanya perbedaan waktu pada setiap indicator perilaku. Pemberian selama 28 hari menujukkan adanya perbedaan signifikan pada penurunan waktu latensi, Panjang lintasan, persentase waktu dan frekuensi kuadran. Kesimpulan: Berdasarkan hasil, pemberian ASP selama 28 hari dapat menyebabkan adanya perubahan perilaku yang berkaitan dengan fungsi memori pada tikus.
Application of Ionic Liquids based Microwave-Assisted Extraction to Bioactive Compounds Comfrey (Symphytum officinale L.) Leaves Hasan, Nahrul; Mun'im, Abdul; Hayun, Hayun
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 7, No 1: March, 2022
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (816.251 KB) | DOI: 10.30604/jika.v7i1.764

Abstract

Extraction of bioactive compounds from comfrey leaves (Symphytum officinale L.) was carried out by comparing organic solvents and ionic liquids between conventional and microwave-assisted extraction (IL-MAE) methods. The comfrey leaf powder was extracted under various conditions. The types of organic solvents used are 65% ethanol and ionic liquids. The extraction methods used are reflux and microwave-assisted extraction. The ionic liquid was extracted by microwave-assisted extraction with the following conditions: ionic liquid concentration of 1 mol/L, the solid-liquid ratio of 1:20 (g/mL), extraction time of 10 minutes, and power of 30% (270 Watt). The total phenolic content of the extract was analyzed with a microplate reader. Allantoin and retrorsine N-oxide levels were analyzed by thin-layer chromatography – densitometry. MAE extraction in a solvent containing 65% ethanol resulted in the highest total phenolic content of 1.038±0.012. The highest levels of allantoin were also obtained from MAE extraction with 65% ethanol solvent at 2.922 ± 0.123. The highest levels of retrorsine N-oxide were obtained by extraction of MAE with (BMIM)Br with a concentration of 0.049 ± 0.007. Extraction of comfrey leaves using the MAE method of 65% ethanol produced the highest total phenolic and allantoin content compared to other methods. (BMIM) Br extraction with MAE can attract the highest retrorsine N-oxide in comfrey leaves.  Abstrak: Ekstraksi senyawa bioaktif daun komfrey (Symphytum officinale L.) dilakukan dengan membandingkan pelarut organik dan cairan ionik, antara metode konvensional dengan metode microwave assisted extraction. Serbuk daun komfrey diekstraksi dengan berbagai kondisi. Jenis pelarut organik yang digunakan yaitu etanol 65% dan cairan ionik. Metode ekstraksi konvensional yang dilakukan, yaitu refluks dan microwave-assisted extraction. Cairan ionik diekstraksi denganmicrowave-assistedextraction dengan kondisi: konsentrasi Cairan ionik 1 mol/L, Rasio padatcair 1:20 (g/mL), waktu ekstraksi 10 menit dan power 30% (270 Watt). Kadar fenol total dalam ekstrak dianalisis dengan microplate reader. Sedangkan kadar allantoin dan retrorsine N-oxide dianalis dengan kromatografi lapis tipis–densitometri. Ekstraksi MAE dengan pelarut etanol 65% menghasilkan kadar fenol total tertinggi, yaitu 1,038 ± 0,012. Kadar Allantoin tertinggi didapatkan juga dari ekstraksi MAE dengan pelarut etanol 65% sebanyak 2,922 ± 0,123. Kadar retrorsin N-oksida tertinggi didapatkan dengan ekstraksi MAE dengan (BMIM) Br dengan konsentrasi 0,049 ± 0,007. Ekstraksi daun komfrey dengan metode MAE etanol 65% menghasilkan kadar fenol total dan allantoin paling tinggi dibandingkan dengan metode lain. Ekstraksi (BMIM) Br dengan MAE dapat menarik kadar retrorsin N-oksida paling tinggi dalam daun komfrey.
Co-Authors . Katrin Adisti, Adisti Agus Purnomo Aksa, Awaluddin Al Maghfuri, Rahmah Salsabila Amalia, Sariayuningsi Aminuddin, Lutfi Hadi Ariestanti, Donna Maretta Aryani, Dewi Erly Juliyani Fadhila, Redhalfi Fadlina Chany Saputri Fahleni Fahleni Febrina Amelia Saputri, Febrina Amelia Firdayani Hasan, Nahrul Hayun Hayun, Hayun Herman, MJ. Hherman, M Hiola, Dewi Suryaningsi Hunawa, Rachmawaty Dirham Hutami, Riska Amalia Putri Irma Rumtianing Uswatul Hanifah James, Richard Johari Joshita Djajadisastra, Joshita Khoirun Nisa Kristanty, Ruth Elenora Lukman Santoso Magfirah, Anisah Maghfuri, Rahmah Salsabila Al Mamin, Ratnawaty Miftachul Ulum, Miftachul Miftahul Huda Musyabirah, Musyabirah Noorwati Sutandyo Prisnu Tirtanirmala Putri, Chinthia Rahadi Putri, Salsabila Nursyifa Raharni Raharni RAMADON, DELLY Ramlawati Ramlawati Ridho Rokamah Sarjaini Jamal Septiani, Rosalina Mesusi Silvia Surini Sri Wardatun Sriana Azis Sudibyo Supardi Suliasih, Babay Asih Suswidiantoro, Vicko Syam, Farha Mutia Wirda Y Dulahu Yahdiana Harahap Yunus, Sitti Rahma Zawawi, Abdullah