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Penggalih Mahardika Herlambang
Universitas Wahid Hasyim
Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Education Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences

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Antibacterial Activity of Bacteriocin from Pediococcus pentosaceus Against Propionibacterium acnes: Molecular Docking, In Vitro, and 16S rRNA Genetic Identification Pribadhi, Adhitya Naufal; Herlambang, Penggalih Mahardika; Purwaningrum, Ellyka
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.943-949

Abstract

This study aimed to evaluate the antibacterial potential of bacteriocin produced by lactic acid bacteria against Propionibacterium acnes through an integrative approach involving molecular docking, in vitro assays, and genetic identification using 16S rRNA sequencing. The target protein PDB 7LBU, representing the cell wall of P. acnes, was docked with Small Bacteriocin obtained from PubChem. The best binding affinity was recorded at –7.5 kcal/mol, indicating a stable interaction, supported by cavity analysis and ligand–protein interaction mapping using PyMOL. The results of the in vitro study, as determined by antibacterial activity testing against P. acnes, showed an average inhibition zone of 20.6 mm. In addition, genetic identification through BLAST confirmed the isolate as Pediococcus pentosaceus strain DSM 20336 with a similarity of 99.64%. These findings indicate that the bacteriocin derived from P. pentosaceus has promising potential as a natural agent in the development of alternative therapies for acne.
Co-Authors Anis Fuad Antono Suryoputro Aryoseto, Lukman Dian Rudy Yana Endang Sutisna Sulaeman Fatmawati, Widi Hendro Wijayanto Hendry Gunawan Lukman Aryoseto Murni Murni Murni Murni Nanang Wiyono Nurhasmadiar Nandini Priaji Setiadani Pribadhi, Adhitya Naufal Purwaningrum, Ellyka Rani Tiyas Budiyanti Rido Muid Riambodo Septo Pawelas Arso Setiadani, Priaji Sudaryanto Sudaryanto Sulaeman, Endang Sutisna Sylvia Anjani Wulan Kusumastuti Zaliyanti, Vera