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Journal : Jurnal Biosains Pascasarjana

ANALYSIS OF SEIZURES IN PATIENTS WITH MOTHERS HAVING A HISTORY OF Toxoplasma gondii INFECTION Nurdianto, Arif Rahman; Apsari, Francisca Cindy Meilia; Safira, Adelia; Hardiwan, Hanalda Wanda
Jurnal Biosains Pascasarjana Vol. 26 No. 2 (2024): JURNAL BIOSAINS PASCASARJANA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v26i2.2024.99-112

Abstract

Toxoplasmosis is a disease caused by the parasite Toxoplasma gondii, with high prevalence in Southeast Asia, including Indonesia. This infection can cause brain damage and is associated with diseases such as epilepsy. This study aims to analyze the occurrence of seizures in patients whose mothers have a history of T. gondii infection. Toxoplasmosis during pregnancy can be transmitted to the fetus via the placenta, causing severe fetal tissue damage and potentially triggering neurological disorders like epilepsy. Pathophysiological mechanisms include increased blood-brain barrier permeability, excitotoxicity, and damage to glutamatergic receptors and mitochondria. In Indonesia, the prevalence of toxoplasmosis ranges from 40%-60%, with risk factors including contact with stray cats and consuming raw meat. This study utilizes a literature review method to investigate the relationship between maternal T. gondii infection and the incidence of epilepsy in offspring. The findings suggest that maternal T. gondii infection during pregnancy significantly increases the risk of epilepsy in offspring. Effective public health measures are crucial for raising prevention awareness and improving access to comprehensive prenatal care.
DNA TOUCH STR CODIS AS LEGITIMATE EVIDENCE IN UNCOVERING CRIMINAL ACTS Nurdianto, Arif Rahman; Setiawan, Fery; Yudianto, Ahmad; Nurdianto, Rizal Fauzi; Sunariani, Jenny
Jurnal Biosains Pascasarjana Vol. 26 No. 1 (2024): JURNAL BIOSAINS PASCASARJANA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v26i1.2024.77-86

Abstract

The identification process at the crime scene (TKP) is one of the essential tasks carried out by police investigators. One critical aspect is the collection and analysis of evidence found at the crime scene, referred to as biological evidence (BB). This evidence serves as a crucial source for determining whether an incident occurred and, if so, whether it was a suicide or another criminal act (such as murder, etc.). The biological evidence found can be analyzed using molecular serobiology approaches, which are rapidly advancing in the fields of forensic medicine and medicolegal practice. One such approach involves utilizing DNA traces, although a common challenge is that often the DNA recovered at crime scenes is degraded. Therefore, a DNA amplification method utilizing the Polymerase Chain Reaction (PCR) technique, along with the short tandem repeat (STR) – CODIS identification approach, is necessary. The analysis of DNA traces using the STR-CODIS approach enables investigators to determine whether the incident was purely criminal, a suicide, or another type of accident involving the victim. Furthermore, the DNA analysis using the STR-CODIS method can also aid in identifying the victims discovered at the crime scene.