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All Journal Jurnal Farmasi Udayana Jurnal Sains dan Teknologi Pharmaciana: Jurnal Kefarmasian Farmasains : Jurnal Ilmiah Ilmu Kefarmasian JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Riset Kesehatan Nasional Jurnal Ilmiah Medicamento Jurnal Penelitian Agama Hindu Jurnal Kesehatan Primer JRKN Usadha Borneo Journal of Pharmacy
Dwi Arymbhi Sanjaya
Universitas Mahasaraswati Denpasar
Religion Agriculture, Biological Sciences & Forestry Humanities Computer Science & IT Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Journal : Jurnal Ilmiah Medicamento

 1 
Studi Retrospektif Gambaran Resistensi Bakteri terhadap Antibiotik: Ni Kadek Sukertiasih; Fitria Megawati; Herleeyana Meriyani; Dwi Arymbhi Sanjaya
Jurnal Ilmiah Medicamento Vol 7 No 2 (2021): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v7i2.2177

Abstract

Menurut Center for Disease Control and Prevention resistensi bakteri terhadap antibiotik masih menjadi masalah kesehatan global. Tingginya angka kejadian resistensi bakteri terhadap antibiotik maka perlu dilakukan suatu upaya pengendalian penggunaan antibiotik. Pengendalian penggunaan antibiotik bertujuan memberikan informasi pola penggunaan antibiotik lebih bijak yang dapat dilakukan dengan cara audit jumlah penggunaan antibiotik di rumah sakit. Tujuan dari penelitian ini adalah untuk mengetahui gambaran persentase resistensi bakteri terhadap antibiotik. Penelitian ini menggunakan rancangan deskriptif. Pengambilan data dilakukan secara restrospektif dari data peta kuman pada periode 2019 – 2020. Penelitian ini di lakukan di Rumah Sakit Umum Pemerintah di Denpasar. Sampel penelitian ini adalah data peta kuman periode 2019- 2020. Hasil penelitian ini bakteri Gram-positif, Gram-negatif, tiga bakteri penyebab infeksi terbanyak pada bakteri Gram-positif yaitu Staphylococus Coagulase Negatif (43%), Enterococus. sp (10%), Staphylococcus aureus (36%). Dan pada bakteri Gram-negatif yaitu Escherichia coli (32%), Pseudomonas aeruginosa (12%) dan Klebsiella pneumoniae (12%). Pada bakteri Gram-positif antibiotik yang masih dapat di rekomendasikan untuk terapi yaitu antibiotik ampisilin sulbaktam, siprofloksasin dan levofloksasin. Sedangkan pada bakteri Gram-negatif antibiotik yang masih dapat di rekomendasikan untuk terapi yaitu Sefoperason Sulbaktam dan Sefepim
Kualitas Penggunaan Antibiotik pada Pasien Community-Acquired Pneumonia di Salah Satu Rumah Sakit di Bali Meriyani, Herleeyana; Sanjaya, Dwi Arymbhi; Juanita, Rr. Asih; Siada, Nyoman Budiartha
Jurnal Ilmiah Medicamento Vol 10 No 1 (2024): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v10i1.7592

Abstract

Community-acquired pneumonia (CAP) is an infectious disease with high morbidity and mortality rates. Antibiotics are essential therapies for bacterial CAP. The use of antibiotics is a critical point in CAP treatment. Inappropriate use of antibiotics leads to antibiotic resistance. The study aimed to evaluate the proper use of antibiotics in CAP patients and identify the relationship between the appropriate use of antibiotics and the use of single/combined antibiotics with prolonged length of stay. This study was a cross-sectional study with retrospective data collection at a general hospital in Bali. Evaluation of the proper use of antibiotics was done using the Gyssens algorithm. The relationship between the appropriate use of antibiotics and the type of antibiotic (single/combined) with the length of stay was carried out using the Chi-square test with a 95% confidence interval. There were 151 CAP patients as samples in this study consisting of 55.63% men and 44.37% women with a median age of 60 years (18-89). The appropriate use of antibiotics was 17.88%, while 82.18% of the total antibiotic use was inappropriate. The Inappropriate use of antibiotics in category IIA (incorrect dosage) is 3.97%, category IIIB (inappropriate interval) is 4.64%, category IVC (cheaper alternative antibiotics were available) is 41.72%, and category V (no indication) is 37.79%. There is no significant relationship between the appropriate use of antibiotics and prolonged LOS [p>0.05; OR: 1.132 (CI: 0.466-2.746)] however the use of antibiotics (single or in combination) significantly affects the prolonged LOS [p<0.05; OR: 0.027 (CI: 0.004-0.204)].
Studi Retrospektif Penggunaan Antibiotik pada Pasien Covid-19 dengan Pneumonia di Rumah Sakit “X” Provinsi Bali, Indonesia Siada, Nyoman Budiartha; Juanita, Rr Asih; Sanjaya, Dwi Arymbhi; Meriyani, Herleeyana
Jurnal Ilmiah Medicamento Vol 10 No 1 (2024): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v10i1.7637

Abstract

COVID-19 with bacterial pneumonia co-infection is a condition with bacteria present in COVID-19 patients. The prevalence of bacterial co-infection in COVID-19 patients ranges from 12.4%–50%. This study aims to determine the relationship between the appropriate use of antibiotics and the severity of inpatients with COVID-19 and pneumonia co-infection at Hospital "X" Bali Province, Indonesia. This research is an observational study with a cross-sectional approach. Data collection was carried out retrospectively on medical record data of COVID-19 inpatients with pneumonia co-infection at Hospital "X" Bali Province, Indonesia for the period January - December 2021. The sampling technique used total sampling according to inclusion and exclusion criteria. Appropriate use of antibiotics antibiotic was analyzed using Pharmaceutical Care Network Europe (PCNE) version 9.1. The patient severity index was an assessment based on the Pneumonia Severity Index (PSI) score. The relationship between the appropriate use of antibiotics and the severity of inpatients with COVID-19 and pneumonia co-infection was analyzed using Fisher's test. Of the 80 COVID-19 inpatients with pneumonia co-infection, 90% experienced inappropriate use of antibiotics. Fisher's test results showed that there was no significant relationship between the appropriate use of antibiotics and the severity of inpatients with COVID-19 and pneumonia co-infection at Hospital "X" Bali Province, Indonesia (p > 0.05).
Efektivitas dan Efek Samping pada Terapi Multi-Drug-Resistant Tuberculosis (MDR-TB): Kajian Literatur Sanjaya, Dwi Arymbhi; Meriyani, Herleeyana; Juanita, Rr. Asih; Siada, Nyoman Budiartha; Noviani, Lusy
Jurnal Ilmiah Medicamento Vol 11 No 1 (2025): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v11i1.9685

Abstract

Multi-drug-resistant tuberculosis (MDR-TB) leads to a reduced cure rate for tuberculosis treatment. The global number of MDR-TB cases remained relatively stable between 2015 and 2020 but increased in 2021. In 2020, the World Health Organization (WHO) estimated 437,000 MDR-TB cases worldwide, which rose to 450,000 cases in 2021. Various treatment regimens recommended by the WHO require a review of the literature on the efficacy and side effects of drug use in MDR-TB. This review aims to provide updated information that can be used as a reference for the early identification and management of side effects. The article was a narrative review that collected and analyzed information from various international articles on databases such as PubMed, PlosOne, and ScienceDirect from January 2014 to June 2024. A total of six relevant articles were synthesized from 609 articles. The effectiveness of MDR-TB therapy with WHO-recommended drugs has shown a high cure rate (cured>50%). The incidence of side effects in MDR-TB therapy is smaller compared to the effectiveness of treatment. However, a study conducted at Wuhan Jinyintan Hospital in China from July 2019 to December 2020 showed that all study subjects experienced side effects. This included nausea and vomiting from protionamide, gatifloxacin, and ethambutol; hyperuricemia from pyrazinamide, and hyperpigmentation from clofazimine. It is recommended that a therapy regimen be selected based on culture test results, patient conditions, and drug availability in each country.
Penggunaan Antibiotik dan Resistensi Escherichia coli and Klebsiella pneumoniae: Studi Ekologikal Lima Tahun di Sebuah Rumah Sakit Umum Daerah Sanjaya, Dwi Arymbhi; Meriyani, Herleeyana; Juanita, Rr. Asih; Siada, Nyoman Budiartha; Mahaputra, Yudistira; Kamalia, Made Gek Adisti
Jurnal Ilmiah Medicamento Vol 11 No 2 (2025): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v11i2.11156

Abstract

Antibiotic resistance is a growing global health threat, partly driven by high antibiotic consumption. The World Health Organization (WHO) has identified critical-priority bacteria, including Escherichia coli and Klebsiella pneumoniae, due to their increasing resistance to multiple antibiotics. This study aimed to evaluate the correlation between antibiotic consumption and resistance rates in Escherichia coli and Klebsiella pneumoniae. This ecological study was conducted at a Regional Hospital in Indonesia based on retrospective inpatient data from January 2019 to December 2023. The population in this study is all data on systemic antibiotic consumption based on the J01 category of the Anatomical Therapeutic Chemical/Defined Daily Dose (ATC/DDD) classification system and antibiogram from inpatient databases. Pearson and Spearman’s rank correlation analyses were performed to examine the associations between systemic antibiotic consumption levels and the percentage of Escherichia coli and Klebsiella pneumoniae resistance to other antibiotics. The most frequently used antibiotics were cefixime (305.664 DDD/100 bed-days), levofloxacin (139.552 DDD/100 bed-days), and ceftriaxone (109.805 DDD/100 bed-days). A strong and statistically significant correlation was observed between doxycycline consumption and Escherichia coli resistance to meropenem (r=0.894; p=0.041). Moreover, consumption levels of cefazolin, ceftazidime, cefepime, and ciprofloxacin were correlated with Escherichia coli resistance to ceftriaxone (p<0.05), while cefoperazone use demonstrated a very strong and statistically significant correlation with Escherichia coli resistance to ampicillin-sulbactam (r=0.952; p=0.012). Conversely, no significant correlation was found between antibiotic consumption and resistance in Klebsiella pneumoniae, suggesting that alternative factors such as intrinsic resistance mechanisms, mobile genetic elements, and environmental reservoirs may influence resistance development.
Co-Authors AA Istri Mas Padmiswari Agus Baratha Suyasa Asthadi Mahendra Bhandesa, Asthadi Mahendra Chusna, Nurul Emanuel Ileatan Lewar Erna Cahyaningsih Fitria Megawati Herleeyana Meriyani I Gede Agus Shuarsedana Putra I Putu Yudistira Mahaputra Ida Ayu Manik Damayanti Kamalia, Made Gek Adisti Ketupapa, Florentina Gabriela Ketut Agus Adrianta Luh Risma Putri Rahayu Made Agus Deny Mahendra Putra Made Gek Adisti Kamalia Mahaputra, I Putu Yudistira Mahaputra, Yudistira Mendra, Ni Nyoman Yudianti Meriyani, Herleeyana Ni Kadek Sukertiasih Ni Luh Kade Arman Anita Dewi Ni Luh Putu Inca Buntari Agustini Ni Made Dwi Mara Widyani Nayaka Ni Made Wiwik Setiawati Ni Wayan Sukma Antari Noviani, Lusy Nyoman Budiartha Siada Puspawati, Made Putu Era Sandhi Kusuma Yuda Putu Sukma Purnamasari RR. Asih Juanita Sukmayanti, Ni Kadek Swari, Ni Luh Putu Triska Ananda Rahayu Wardani, I Gusti Ayu Agung Kusuma Widnyani, Dewa Ayu Sri Bintang