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All Journal Jurnal Farmasi Sains dan Komunitas JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Pengabdian Masyarakat Teknologi Pertanian Jurnal Farmasi Indonesia Jurnal Veteriner dan Biomedis AS-SHIHA: JURNAL KESEHATAN Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Journal Of Pharmacy
Indriani, Lusi
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Journal : JSFK (Jurnal Sains Farmasi

 1 
Penilaian Efektivitas Antihipertensi dan Efek Samping Obat di RSUP Fatmawati Indriani, Lusi; Rokhmah, Nisa Najwa; Shania, Nur
JSFK (Jurnal Sains Farmasi & Klinis) Vol 9 (2022): J Sains Farm Klin 9(suplemen), Desember 2022
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.9.sup.146-151.2022

Abstract

Hipertensi diartikan sebagai kondisi ketika tekanan darah mencapai atau melebihi 140/90mmHg. Dalam keputusan penggunaan obat selalu mempertimbangkan manfaat dan resikonya. Obat antihipertensi dianggap efektif jika dapat mengontrol tekanan darah. Pada penggunaan obat antihipertensi jangka panjang perlu diwaspadai kemungkinan adanya efek samping. Penelitian ini bertujuan untuk menilai efektivitas dan efek samping obat antihipertensi menggunakan data rekam medis pasien rawat inap di RSUP Fatmawati. Penelitian ini bersifat observasional (non eksperimental). Penentuan efektivitas menggunakan desain pre dan post, dan rancangan cross sectional untuk mengidentifikasi efek samping obat dengan pendekatan secara retrospektif. Pengambilan sampel ditentukan secara purposive berdasarkan kriteria tertentu. Data yang diperoleh dianalisis secara univariat dan bivariat dengan pengujian Wilcoxon, uji Spearman dan uji Fisher’s Exact. Studi ini memberikan hasil bahwa mayoritas pasien rawat inap di RSUP Fatmawati berjenis kelamin perempuan, umumnya menderita hipertensi tingkat 2, lebih banyak mendapatkan terapi gabungan. Terdapat perbedaan tekanan darah sebelum dan setelah pemberian terapi antihipertensi (p<0,05)[A1] [A2] . Kejadian efek samping obat akibat penggunaan antihipertensi ditemukan sebanyak 16%. Tidak ada hubungan yang bermakna antara jenis terapi antihipertensi dengan kejadian efek samping obat.
Treatment Duration and Drug Regimen Correlation with Side Effects Incidence in Drug-Resistant Tuberculosis (DR-TB) Patients at Pulmonary Hospital Indriani, Lusi; Renitia, Gita Iftitah; Setiani, Lusi Agus
JSFK (Jurnal Sains Farmasi & Klinis) Vol 10 No 3 (2023): J Sains Farm Klin 10(3), Desember 2023
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.10.3.320-326.2023

Abstract

The bacteria Mycobacterium tuberculosis causes Drug-Resistant Tuberculosis (DR-TB). Excessive use of drugs canresult in drug resistance with various side effects. This study aimed to analyze the correlation between the treatment duration and drug regimen with the side effects incidence in DR-TB Patients at Pulmonary Hospital Dr. M. Goenawan Partoidigdo (RSPG) Bogor. This is an observational study with a cross-sectional design. Subjects were selected with purposive sampling methods based on inclusion and exclusion criteria. The research showed that DR-TB patients were mostly male (50.2%) with productive age (46.1%). The most common DR-TB treatment experienced by patients in the advanced phase, generally for 9-24 months (75.3%), and the type of drug side effect most experienced was gastrointestinal disorders, that is nausea (55.1%). The use of standard conventional drug regimens mostly in Z, E, Eto, Km, Lfx, Cs (Pyrazinamide, Ethambutol, Ethionamide, Kanamycin, Levofloxacin, Cycloserine) of 51.4%. The chi-square analysis showed no significant correlation between the treatment duration and the incidence of side effects. At the same time, there was a meaningful correlation between the drug regimen (short-term, long-term, and conventional standard regimen) and the side effects incidence. The suspected drugs causing gastrointestinal side effects were pyrazinamide, ethambutol, ethionamide, and levofloxacin. The side effects of arthritic arthralgia were suspected to be caused by pyrazinamide, ethionamide, and levofloxacin.
Anti-inflammatory activity of An Ethanol Extract of Pucuk Merah (Syzigium myrtifolium Walp.) in vivo Nursyafni, Nursyafni; Rahmawati, Ayu; Indriani, Lusi; Ashari, Dicki Hamed
JSFK (Jurnal Sains Farmasi & Klinis) Vol 10 No 3 (2023): J Sains Farm Klin 10(3), Desember 2023
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.10.3.286-292.2023

Abstract

Compared with classical Utilization of medicinal plants with anti-inflammatory properties, it needs to be done to find alternative treatments with relatively more minor side effects, such as Syzygium myrtifolium walp. This study aims to determine the effective dose of ethanol extract of pucuk merah as an anti-inflammatory in 30 male white rats of the Wistar strain. Testing the extract's anti-inflammatory effect was measured by measuring the edema volume on the soles of the rats' feet after being induced with 1% carrageenan with a pletismometer. The test animals were divided into six treatment groups, namely group 1 negative control (Na CMC 1%), group 2 positive control (Na Diclofenac 50 mg/KgBW), group 3 (dose of pucuk merah leaves extract 75 mg/KgBW), group 4 (quantity of pucuk merah leaves extract 100 mg/kgBW), and group 5 (amount of pucuk merah leaves extract 125 mg/kg BW), with observation times of 30, 60, 90, 120, 150, and 180 minutes. The results showed that rats in group 5 with a dose of pucuk merah (125 mg/kgBW) had the best anti-inflammatory effect, with an anti-inflammatory potential of 97% compared to diclofenac sodium.
Antibacterial activities of three species of mangrove leaves extract against Staphylococcus aureus and Escherichia coli Rahmawati, Ayu; Nursyafni, Nursyafni; Herly, Moh. Azhari Herly Azhari; Indriani, Lusi; Lovena, Tri Nova; Khairiah, Kinanti Bahy; Aprilia, Indri
JSFK (Jurnal Sains Farmasi & Klinis) Vol 10 No 3 (2023): J Sains Farm Klin 10(3), Desember 2023
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.10.3.300-306.2023

Abstract

The increasing incidence of infections and drug resistance has led scientists to seek approaches towards medicinal plants that are potentially effective against many microorganisms. Therefore, this study was planned to assess the antibacterial activity of 3 mangrove species (Scyphipora hydrophylaceae C.F.Gaertn., Lumnitzera littorea (Jack) Voigt and Avicennia alba Blume) against Staphylococcus aureus and Escherichia coli bacteria. This study used the disc diffusion method to measure the diameter of inhibition at several concentrations of mangrove leaf ethanol extracts, namely 15%, 10%, 5%, 2.5%, 1.25% and 0.625% b/v as well as positive control cefadroxil for bacteria and DMSO as negative control. The test results showed that ethanol extracts of mangosteen leave Scyphipora hydrophylaceae C.F.Gaertn and Lumnitzera littorea (Jack) Voigt had a solid response to Escherichia coli bacteria and moderate potential against S. Aureus bacteria—no antibacterial activity against both test bacteria for Avicennia alba mangrove. This study concludes that Scyphipora hydrophylaceae C.F.Gaertn and Lumnitzera littorea (Jack) Voigt have potent antibacterial activity against Escherichia coli, but Avicennia alba has no antibacterial activity.
Co-Authors Afandi, Ayu Indah Lestari Arabella Natasya Ashari, Dicki Hamed AYU RAHMAWATI Bobihu, Ijhan Cahyani, Nisa Dwi Dewi Gulyla Hari Gulyla Hari, Dewi Hendri Sandi, Nofri Herly, Moh. Azhari Herly Azhari Hidayanti, Tiyan Indri Aprilia, Indri Khairiah, Kinanti Bahy Lasena, Nurhayati Lovena, Tri Nova Lubis, Nursyafni Mahmud, Sri Anggita MOERFIAH . Muhammad Arif Najwa Rokhmah, Nisa Nhestricia, Nhadira Noveri Rahmawati Nurbaiti Nurdina Putri Nursyafni Nursyafni, Nursyafni Pontoh, Moh Fais Pradana, Faisal Rahim, Nur Cindi Rahminiwati, Min Ramlan Mustafa Renitia, Gita Iftitah Ria Indriani Shania, Nur Sulistio, Eko Nugraha Yanti Saleh Zunnita, Oktaviana