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All Journal Pharmascience Jurnal Ilmiah Manuntung PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Pengabdian Kepada Masyarakat (Mediteg) Jurnal Insan Farmasi Indonesia Jurnal Bakti Untuk Negeri
Niah, Rakhmadhan
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Physics Public Health Social Sciences

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Journal : Jurnal Insan Farmasi Indonesia

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FORMULASI DAN EVALUASI FISIK SEDIAAN TABLET NANOPARTIKEL EKSTRAK DAUN DADANGKAK (Hydrolea spinosa L.) Niah, Rakhmadhan; Wahyuono, Subagus; Prihandiwati, Erna
Jurnal Insan Farmasi Indonesia Vol 7 No 3 (2024): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jdkpqw89

Abstract

The utilization of traditional medicines offers a safer alternative for treatment, particularly regarding side effects and toxicity. One herbal plant known for its antioxidant activity is dadangkak leaves (Hydrolea spinosa L.), containing flavonoids, polyphenols, and tannins. Ethanolic extracts of dadangkak leaves with antioxidant potential need development into tablet dosage forms. This study aims to determine the optimal formula for nanoparticle tablets containing dadangkak leaf extract. The extract was obtained via maceration using 96% technical ethanol, followed by evaporation to produce a thick extract. Nanoparticles were prepared by mixing the extract with 96% technical ethanol, distilled water, a chitosan solution in acetic acid, and a NaTTP solution. Particle size was analyzed using a Particle Size Analyzer (PSA). Tablet formulations involved varying concentrations of Na alginate and Avicel PH 102, using direct compression. Results showed that Na alginate and Avicel PH 102 concentrations affected tablet physical properties. Avicel PH 102 increased hardness and disintegration time, while Na alginate increased friability. Based on evaluations, formula 2 was determined to be the best.
Co-Authors Aisyah, Noor Alfiannor, M. Ariani, Novia Aryzki, Saftia Baharsyah, Riki Nirwan Deddy Dharmaji, Deddy Dhiya Kamila, Marsa Eka Kumalasari Febrianti, Dwi Rizki Khadijah, Maulida Kurniawan, Henny Lathifah, Nor Maria Ulfah Ma’ruf, Muhammad Muhammad Hafizh Abiyyu Fathin Fawwazi Norhalisa Normilawati, Normilawati Novita Andriyani Nurjihan, Lu’lu Prihandiwati, Erna Putri, Aisya Novrida Rahma Syari, Aulia Riko Nugroho, Muhammad Riski, Akhmad Rustandi, Tedi Sandi, Dita Ayulia Dwi Subagus Wahyuono Supomo Supomo Susanto, Yugo Susilo, Yudi Hardi Wahyudi Wahyudi Wahyuni, Amaliyah Wandarie, Indah Widodo, Arif Nur Yumassik, Abdul Mahmud