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All Journal e-Journal BUDIDAYA PERAIRAN JURNAL PESISIR DAN LAUT TROPIS JURNAL ILMIAH PLATAX JURNAL PERIKANAN DAN KELAUTAN TROPIS AGRIKAN Jurnal Ilmiah Agribisnis dan Perikanan Omni-Akuatika Eduvest - Journal of Universal Studies
Silvester B Pratasik
Fakultas Perikanan Dan Ilmu Kelautan, Universitas Sam Ratulangi - Manado, Sulawesi Utara
Aerospace Engineering Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Environmental Science Health Professions Neuroscience Social Sciences

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Journal : Eduvest - Journal of Universal Studies

 1 
Malondialdehyde (MDA) Concentration and Histopathological Image of Indomethacine-Induced Wistar Rat,Rattus norvegicus,With Inflammatory Bowel Disease (IBD) After Mas Ngur Oyster (Atactodea striata) Extract Therapy Celcius Waranmaselembun; Agustiana Agustiana; Firlianty Firlianty; Yuliana Anastasia Ngamel; Silvester B. Pratasik
Eduvest - Journal of Universal Studies Vol. 3 No. 3 (2023): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v3i3.764

Abstract

Inflammatory Bowel Disease (IBD) is an inflammatory disease occurring in gastirct tract, particularly colon, that could result from the side effect of anti-inflammatory non-steroid(AINS) drug utilization, such asindomethacine. Mas ngur oysters (Atactodea striata) have long been known by people of Kei-Southeast Mallucas as traditional medicine, but its use in reducing MDA level in rat with IBD has not been studied. This study was aimed at measuring the ability of the bioactive compounds contained in mas ngur oyster powder extract to reduce the MDA level in the ileum of indomethacine-induced rat with IBD and providing the histological image of the ileum after therapized with mas ngur oyster extract. Test animals were 8-12 week old-male rats (Rattus norvegicus) of 150 - 200 g BW. They were separated into 3 groups,healthy, sick (induced with 15 mg/kg BW indomethacine), therapy goups (15 mg/kg BW indomethacine oral induction then treated with mas ngur oyster powder of100, 400, 700 mg/kg BW). Indomethacine induction of 15 mg/kg BWand therapy of mas ngur oyster powder extract were administered orally. MDA level was measured usingThiobarbituric Acid (TBA)test and histological image of the ileum using Hematoxylin-Eosin staining. Results showed that mas ngur extract therapy gave significant effectin MDA level (P<0.05) and difference between the treatments with effective dose of400 mg/kg BW
Co-Authors Adnan Wantasen Agustiana Agustiana Alex D. Kambey Ali Djamhuri Ali, Fajri Nurul Anang Najamuddin Anneke V. Lohoo Antonius Rumengan Ari B. Rondonuwu Bataragoa, M.Sc, Dr. Ir. Nego E. Billy Th. Wagey Calvyn F. A. Sondak, Calvyn F. A. Celcius Waranmaselembun Choirul Anwar Darus S. Paransa Dauhan, Dulce Maria Deiske A. Sumilat Deslie RH Kumampung Elvy L. Ginting Erly Y Kaligis Erly Y. Kaligis, Erly Y. Firlianty Firlianty Firlianty Firlianty Firlianty, Firlianty Firlianty, Firlianty Fitje Losung Frans F. Tilaar Fransine B. Manginsela Gaspar D. Manu, Gaspar D. Gaspar Manu Ginting, Elvy Like Gustaf F. Mamangkey Hengky J. Sinjal, Hengky J. Inggrid M. F Akerina Janny D. Kusen John L. Tombokan Joshian NW Schaduw Joudy R.R. Sangari Juliaan Watung Kalesaran, Ockstan Y. Kondoy, Khiristin Ivone Fisye Lalamentik, Laurentius Th. X. Laura, Azhar Lawrence J. L. Lumingas Leleran, Andreas J. P. L. Lexy K Rarung Malurung, Yulianti - Mamonto, Riswanto Mangindaan, Remy Mantiri, Nicola R. K. Marselo R. Manzanaris Medy Ompi Medy Ompi Meiske S. Salaki Melani, Hellen Menajang, Febry S. I. Menajang, Febry Susana Ivone Moningkey, Ruddy D. Natalie D Rumampuk Nego E. Bataragoa Nego E. Bataragoa, Nego E. Novia A Jambo Pelle, Wilmy E. Purniasih, Ni Komang Pitri Ramadan, Febrian Rangan, Jety K. Rembet, Unstain Remy E. P Mangindaan Rene Charles Kepel, Rene Charles Robert A. Bara Rondonuwu, Arie B. Rondonuwu, Yonatan Y. Runtuwene, Heard C.C. Rustikasari, Irna Salaki, Meiske S. Sambali, Hariyani Sampe, Ayumi Angraini Sampouw, Mouren V. Samuel L. Opa Sangari, Joudy R.R Silvia A. Bangun Sinjal, Henky Stenly Wullur Suria Darwisito Suzanne L Undap Tidore, Fadli Tilaar, Ferdinand F. Tombi, Indra Unstain N. W. J. Rembet Veibe Warouw Wewengkang, Fabiola Wilmy Pelle Yuliana Anastasia Ngamel