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All Journal Media Teknologi Hasil Perikanan Jurnal MIPA PHARMACON Jurnal Bios Logos CHEMISTRY PROGRESS KESMAS Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ The Studies of Social Sciences Vivabio : Jurnal Pengabdian Multidisiplin Jurnal Perempuan dan Anak Indonesia Jurnal Kesehatan Tambusai Jurnal Lentera: Penelitian dan Pengabdian Masyarakat Jurnal Lentera Farma
Siampa, Jainer Pasca
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Journal : Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ

 1 
MEKANISME REAKSI FRAGMENTASI SENYAWA KIMIA DALAM KULIT BUAH ALPUKAT (Persea americana Mill.) Antasionasti, Irma; Sudewi, Sri; Jayanto, Imam; Siampa, Jainer Pasca
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol 2, No 2 (2019)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (855.358 KB) | DOI: 10.35799/pmj.2.2.2019.26528

Abstract

ABSTRACTInvestigation of the fragment structure of ions and fragmentation reaction is crucial and needs to be done to reconstruct the chemical structure of the examined sample. Therefore, it is necessary to study the fragmentation mechanisms of chemical compound that identified from avocado peel to study the rules of the fragmentation reaction that occurs Sample analysis was examined using Gas Chromatography-Mass Spectrometry (GC-MS) with ionization Electron Impact (EI). Two compounds foun in avocado peel are 1,2,4-trihidroksiheptadek-12,16-diyne and 1,2,4-trihidroksiheptadek-16-yne-18-ene following the principle of even electron positive (EE+) which tends to always form even electron positive (EE+) and even electron neutral (EE0). The fragmentation mechanisms in both compounds are σ bond dissociation reaction and i cleavage which forms even electron positive (EE+) and even electron neutral (EE0). The fragmentation mechanism of the compounds in avocado peel can be estimated through interpretation of GC-MS mass spectra with base peak m/z 87. Keywords : Persea americana Mill.; GC-MS; fragmentation; 1,2,4-trihidroksiheptadek-12,16-diyne; 1,2,4-trihidroksiheptadek-16-yne-18-ene ABSTRAKPenyidikan struktur ion-ion fragment serta reaksi fragmentasinya sangat penting dan perlu dilakukan untuk dapat merekonstruksi kembali struktur kimia sampel yang diperiksa. Oleh karena itu, perlu diketahui mekanisme fragmentasi senyawa kimia yang diidentifikasi dari sampel kulit buah alpukat untuk mengetahui kaidah reaksi fragmentasi yang terjadi. Analisis sampel dilakukan menggunakan Gas-Chromatography-Mass Spectrometry (GC-MS) dengan cara ionisasi Electron Impact (EI). Dua senyawa yang terkandung dalam kulit buah alpukat yaitu senyawa 1,2,4-trihidroksiheptadek-12,16-diena dan senyawa 1,2,4-trihidroksiheptadek-16-ena-18-una mengikuti kaidah fragmentasi ion elektron genap positif (EE+) cenderung untuk selalu membentuk ion elektron genap positif (EE+) dan molekul elektron genap netral (EE0). Mekanisme fragmentasi pada kedua senyawa tersebut terjadi melalui reaksi dissosiasi ikatan σ dan reaksi pemutusan induktif membentuk ion elektron genap positif (EE+) dan molekul elektron genap netral (EE0). Mekanisme fragmentasi senyawa dalam kulit buah alpukat dapat diperkirakan melalui interpretasi spektrum massa GC-MS dengan base peak m/z 87. Kata kunci: Persea americana Mill.; GC-MS; fragmentasi; 1,2,4-trihidroksiheptadek-12,16-diena; 1,2,4-trihidroksiheptadek-16-ena-18-una
OPTIMASI FORMULA GEL EKSTRAK KAYU MANIS (CINNAMOMUM BURMANNII) : FRACTIONATION APPROACH Siampa, Jainer Pasca; Lebang, Julianri Sari; Datu, Olvie Syenni; Khairuddin
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 6 No. 2 (2023): Vol. 6, No.2, 2023
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.v6i2.51702

Abstract

Activities outside are unavoidable and lead to increased sun exposure to the skin. The purpose of this study was to formulate a gel using cinnamonraction as active ingredients. Cinnamon is extracted by maceration method using 70% ethanol then fractionated using n-hexane, ethyl acetate, and butanol solvents. The resulting fraction was then tested for total flavonoid content and antioxidant capacity using the DPPH method (2,2-diphenyl, 1-picrylhydrazil). Fractions that have strong antioxidant activity was further used as active ingredients. The test results of the total flavonoid content of n-hexane, ethyl acetate and butanol fractions were 0.265%w/wEQ; 1.035%w/wEQ; and 1.169%w/wEQ respectively. Testing of antioxidant capacity gave an IC50 value of 124.729ppm; 8.636ppm; and 7.858ppm. Furthermore, the butanol fraction was selected as the best fraction and used as the active ingredient of the gel formula. In conclusion, the butanol fraction could be formulated into a gel that met the requirements of physical characteristics.Keywords: butanol fraction, cinnamon, total flavonoid, antioxidant capacity, gel fraction
PENGEMBANGAN FORMULA BODY LOTION EKSTRAK KAYU MANIS (Cinnamomum burmannii) SEBAGAI PELEMBAB : UJI EFEKTIVITAS MENGGUNAKAN SKIN MOISTURE ANALYZER Siampa, Jainer; Papu, Adelfia; Jayanto, Imam
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 7 No. 2 (2024): Jurnal Farmasi Medica/Pharmacy Medical Journal
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.v7i2.58948

Abstract

Nowadays, modern society's activities are mostly carried out outside, so the harmful effects of changes in temperature, exposure to UV radiation, pollution and air humidity, namely a decrease or even loss of skin moisture, cannot be avoided. If untreated, reduced moisture in the skin will not only make the skin scaly, but will also cause irritation or injury to the skin. This research aimed to test the moisturizing effect of the best body lotion formula and also test irritation and hedonics. This test had received ethical approval and was carried out on the same panelists and the moisturizing effect of the preparation was measured using a skin moisture analyzer. The results obtained show that the formulation could increase the moisture of the panelists' skin by 56% and irritation testing showed no redness and swelling. So it can be concluded that the cinnamon extract body lotion formula had a moisturizing effect and not irritating so it was harmless to apply on the skin.
PEMBUATAN CUKA SALAK DAN PENGARUH PEMBERIAN CUKA SALAK TERHADAP KADAR ASAM URAT TIKUS PUTIH HIPERURISEMIA Datu, Olvie Syenni; Siampa, Jainer Pasca; Lebang, Julianri Sari
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 7 No. 2 (2024): Jurnal Farmasi Medica/Pharmacy Medical Journal
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Hiperurisemia adalah penyakit metabolik yang disebabkan oleh kelainan metabolisme purin, terutama karena peningkatan pembentukan atau penurunan ekskresi urat. Data Organisasi Kesehatan Dunia (WHO) menunjukkan bahwa terdapat 7,44 juta kasus hiperurisemia di seluruh dunia pada tahun 2017 dan hasil Riset Kesehatan Dasar Indonesia (Riskesdas) pada tahun 2018, prevalensi penyakit sendi di Provinsi Sulawesi Utara sebesar 8,35%, di atas rata-rata nasional sebesar 7,3%, selain faktor genetik makanan tinggi purin juga menjadi faktor risiko asam urat. Salak merupakan salah satu buah yang potensial untuk dikembangkan menjadi produk farmasi. Cuka adalah produk yang diperoleh dari fermentasi bahan yang mengandung gula atau pati melalui proses fermentasi. Tujuan penelitian ini adalah untuk memformulasikan cuka salak dan untuk menguji efek pemberian cuka salak pada tikus putih hiperurisemia yang diinduksi dengan jus hati ayam. Cuka salak diperoleh dari fermentasi buah salak dengan menggunakan bakteri Saccharomyces cereviciae dan bakteri acetobacter aceti. Data menunjukkan bahwa cuka salak memiliki aroma khas buah salak dengan pH 3,46. Aktivitas antihiperurisemia menunjukkan bahwa cuka salak memiliki potensi untuk menurunkan kadar asam urat pada tikus putih hiperurisemia.
Co-Authors Abdullah, Surya Sumantri Adelfia Papu Adithya Yudistira Antasionasti, Irma Anton, Nurhati Asep Rahman, Asep Datu, Olvie Syenni Defny S. Wewengkang, Defny S. Desinta, Ni Wayan Dian Pratiwi Edi, Hosea Jaya Edwin de Queljoe Fatimawali . Gayatri Citraningtyas Hosea J. Edy, Hosea J. Hosea Jaya Edy Jayanto, Imam Julianri Sari Lebang, Julianri Sari Kalesaran, Angela Fitriani Clementine Karlah L. R. Mansauda Khairuddin Lahamendu, Beatriks Lestari, Utami Sasmita Masengi, Kyoko Itsuko Etsuko Gabriela Meilani Jayanti Nelwan, Sabine A. Nurbayasanti, Ni Luh Nurmiati Nurmiati Paputungan, Wazhifa Andarini Paulina yamlean Puluh, Esterlina A. Puluh, Esterlina Aldora Purnomo, Novia Hanna Purukan, Christy Rajab, Mustika Nur Riani Mansauda, Karlah Lifie Ritan, Yosefa E.H. Rorrong, Arnelita Gloryensha Rumayar, Ricky C. Rumoroy, Jhon D. Sahi, Makbul Renaldi Sandala, Ecleysia Retika Frolen Sekeon, Crista Gretasia Seru, Eufrasia R. Shintia, Arini Somba, Gichella C. J. Somba, Gichella C.J Sri Sudewi, Sri Sukartiningsih, Yulita Ni Nyoman Sukartiningsih, Yulita Ni Nyoman Tri Tamimi, Alyah A.P Ticoalu, Pricilia Kesia TRINA EKAWATI TALLEI Tulung, Grace Laury Tumilaar, Sefren Geiner Tunas, Theresia H. Widdhi Bodhi Widiastuti, Priskha Widya Astuty Lolo, Widya Astuty Wiyono, Weny Indayany