Article Per Year (5 Year)
p-Index From 2020 - 2025
1.683
P-Index
This Author published in this journals
All Journal Jurnal Kedokteran Diponegoro Jurnal Epidemiologi Kesehatan Komunitas Medica Hospitalia Diponegoro International Medical Journal (DIMJ) Ophthalmologica Indonesiana
Saubig, Arnila Novitasari
Unknown Affiliation
Dentistry Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

Published : 10 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 4 Documents
Search
Journal : Ophthalmologica Indonesiana

 1 
SURGICAL OUTCOMES OF STRABISMUS CORRECTION IN LARGE ANGLE EXOTROPIA Sadida, Rahmah; Ekowati, Liana; Saubig, Arnila Novitasari
Majalah Oftalmologi Indonesia Vol 49 No S1 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/xgn66x65

Abstract

Introduction and Objective: Surgery is one of the treatment options for strabismus. The success rates of surgical interventions, as reported in a number of different studies, vary widely. There is no database of surgical outcome in large angle exotropia patient undergoing surgery in Semarang, Central Java. This study aims to evaluate the surgical outcome of strabismus correction in large angle exotropia in Dr. Kariadi General Hospital.  Methods: A retrospective study held from the medical record of patients with diagnosis large angle (>50?) exotropia undergoing strabismus correction surgery from January 2020-December 2022 in Dr. Kariadi General Hospital, Semarang. The clinical characteristics: sex, age, angle of exodeviation, amblyopia condition, sensory deprivation, and postoperative alignment were obtained. Surgical outcome measured with follow up of angle deviation in one month dan three months follow up after surgery.  Result: Totally 59 large angle exotropia patients were obtained with 31 (53%) were woman and 28 (47%) were man, range aged 1 year to 53 years old had preoperative angle of exodeviation 51->85 ?, 6 (10%) had amblyopia, 11(18.6%) had sensory deprivation. By the 3 months post-operative visit, 100% of all patients reported orthophoria.  Conclusion: This study found the outcome of strabismus correction for large angle exotropia is satisfactory. Two- or three-muscle surgery provides an effective means for treatment of large angle exotropia.  Keywords: large angle exotropia, exodeviation, strabismus  
Inhibition of Caspase-3 Provides Neuroprotection for Retina Ganglion Cells againts NMDA-induced Exitotoxicity in Wistar Rats: Oral Presentation - Observational Study - Resident Widyarini, Andriati Nadhilah; Maharani; Rahmi, Fifin L; Nugroho, Trilaksana; Saubig, Arnila Novitasari; Istiadi, Hermawan
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/fs7v9v35

Abstract

Introduction & ObjectivesGlaucoma is a disorder characterized by the presence of optic neuropathy. Visual impairment inglaucoma is caused by retinal ganglion cell (RGC) apoptosis associated with N-methyl-D-aspartate(NMDA)-mediated excitotoxicity. Excitotoxicity causes an increase in calcium in cells as well asactivation of caspase-3. Glaucoma therapy is currently given to reduce intraocular pressure (IOP),but the damage is still progressing progressively. Hesperidin is known as a neuroprotector that cansuppress calpain overactivation in NMDA-treated retina, thereby reducing the upregulation of TNF-,an inflammatory cytokine, inhibiting calpain activation by suppressing oxidative stress, andattenuating caspase-3 activation. The aim of this study to proving the effect of oral Hesperidin on theexpression of caspase-3 Retinal Ganglion Cell in Wistar rats model of NMDA-induced glaucoma. MethodsExperimental research with post test design only randomized control trial Wistar rats with NMDAinduction were divided into 2 treatment and control groups. The treatment group was given oralHesperidin at a dose of 100mg/kg/day while the control group was given Na-CMC 182 mg/kg/day for3 weeks. Retinal caspase-3 expression was examined by immunohistochemical staining. Data werecollected and processed and then the Mann- Whitney test was performed. (significant p<0.05) ResultsThe mean percentage and intensity of RGC caspase-3 expression in the treatment group were 4.29 ±0.49 it was significantly lower than the control group 6.29 ± 0.95 (p value = 0.003). ConclusionHesperidin provides neuroprotection for RGC againts NMDA- induced exitotoxicity by inhibition ofcaspase-3.
Effect of Vitamin D3 on Caspase-3 Expression of Retinal Ganglion Cell Wistar Rats with N-Methyl-D-Aspartate-induced Model of Glaucoma Mahanani, Seia; Maharani; Saubig, Arnila Novitasari; Winarto; Dharma, Andhika Guna; Hermawan
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/4zctdm27

Abstract

Introduction & ObjectivesIntroduction: Vitamin D is a neuroprotective neurosteroid hormone with antioxidant, antiinflammatoryand anti-ischemic properties that can reduce the entry of intracellular calcium,thereby reducing cytochrome-c, modulating inflammation, increasing Nitric Oxide production bysuppressing oxidative stress and activating caspase-3 activation. Excitotoxicity due to N-Methyl-DAspartatecauses caspase-3 activation due to increased calcium in cells and describes thepathogenesis of vascular factor glaucoma due to retinal ganglion cell (RGC) damage in the absenceof an increase in intraocular pressure. RGC damage can be assessed by the expression of caspase-3which is a proapoptotic agent that acts as the main effector caspase in the mechanism of apoptosis.Objective: Proving the effect of vitamin D3 on caspase-3 expression of retinal ganglion cells wistarrats in NMDA-induced glaucoma models. MethodsAn experimental study, using post-test only randomized controlled group design, was done on 14male NMDA-induced glaucoma wistar rats, divided into 2 groups. The treatment group was givenoral vitamin D3 500 IU/kgBW every 24 hours for 10 weeks, while the control group was givenaquadest. Immunohistochemistry was used to measured caspase-3 expression. Mann-Whitneyanalized non-parametric difference test (Significant p<0.05). ResultsCaspase-3 expression of retinal ganglion cell was significantly lower (p=0.004) in treatment group(mean=5,29 ± 0,76) compared to control group (mean=6,71 ± 0,49). ConclusionOral vitamin D3 has an effect on caspase-3 expression of retinal ganglion cells wistar rats in NMDAinducedglaucoma models. Further research is needed to investigate the protective role of vitaminD3 on glaucoma patients.
SURGICAL OUTCOMES OF STRABISMUS CORRECTION IN LARGE ANGLE EXOTROPIA Sadida, Rahmah; Ekowati, Liana; Saubig, Arnila Novitasari
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/j47xb287

Abstract

Introduction & ObjectivesSurgery is one of the treatment options for strabismus. The success rates of surgical interventions,as reported in a number of different studies, vary widely. There is no database of surgical outcomein large angle exotropia patient undergoing surgery in Semarang, Central Java. This study aims toevaluate the surgical outcome of strabismus correction in large angle exotropia in Dr. KariadiGeneral Hospital. MethodsA retrospective study held from the medical record of patients with diagnosis large angle (>50?)exotropia undergoing strabismus correction surgery from January 2020-December 2022 in Dr.Kariadi General Hospital, Semarang. The clinical characteristics: sex, age, angle of exodeviation,amblyopia condition, sensory deprivation, and postoperative alignment were obtained. Surgicaloutcome measured with follow up of angle deviation in one month dan three months follow up aftersurgery. ResultsTotally 59 large angle exotropia patients were obtained with 31 (53%) were woman and 28 (47%)were man, range aged 1 year to 53 years old had preoperative angle of exodeviation 51->85 ?, 6(10%) had amblyopia, 11(18.6%) had sensory deprivation. By the 3 months post-operative visit,100% of all patients reported orthophoria. ConclusionThis study found the outcome of strabismus correction for large angle exotropia is satisfactory. Twoor three-muscle surgery provides an effective means for treatment of large angle exotropia.
Co-Authors Arief Wildan, Arief Arwinda Nugraheni Dhaniswara, Andhika Adristia Dharma, Andhika Guna Dodik Pramono Ekowati, Liana Fifin Luthfia Rahmi Fitriani, Rizky Hari Peni Julianti HERMAWAN Hermawan Istiadi Mahanani, Seia Maharani Maharani Maharani, Maharani Nugroho, Trilaksana Purnomo, Adella Setyo Rahmi, Fifin L Riski Prihatningtias, Riski Ryan, Kevin Arfa Sadida, Rahmah Uyun, Fuadah Widyarini, Andriati Nadhilah WINARTO