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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Mandala Pharmacon Indonesia Jurnal Mandala Pengabdian Masyarakat Jurnal DiMas (Jurnal Pengabdian Kepada Masyarakat) Sciences of Pharmacy AMMA : Jurnal Pengabdian Masyarakat
Alaydrus, Syafika
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Journal : Jurnal Penelitian Pendidikan IPA (JPPIPA)

 1 
Subchronic Toxicity Test of Purple Leaves Ethanol Extract (PLEE) on the Histopathological Picture of the Pancreas of Wistar Rats Wardani, Yunira; Dewi, Niluh Puspita; Alaydrus, Syafika; Rachmawati, Meike
Jurnal Penelitian Pendidikan IPA Vol 10 No 6 (2024): June
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i6.8069

Abstract

Medicinal plants are considered a rich source of bioactive metabolites and have the potential for the discovery and development of new drugs, one of which is the purple leaf plant which is known to treat various diseases. The aim of this research was to determine the effect of administering purple leaf ethanol extract over a certain period of time at doses of 500 mg/kgBB, 2.000 mg/kgBB and 5.000 mg/kgBB on the histopathology of the Wistar rat pancreas. In this study, an experimental method was used with a randomized block design, using 20 male Wistar rats which were divided into 4 research groups, 1 control group which was given Na-CMC. and 3 treatment groups were given purple leaf ethanol extract at a dose of 500 mg/kgBB (P1), dose of 2.000 mg/kgBB (P2) and  dose of 5.000 mg/kgBB (P3). The test preparation was administered orally, for 28 days. The results of subchronic toxicity testing of purple leaf ethanol extract on Wistar rats carried out for 28 days, up to a dose of 5.000 mg/kg BB, showed that at a dose of 2.000 mg/kg BB – 5.000 mg/kg BB it was toxic to the histopathology of the Wistar rats pancreas, which was characterized by the presence of cell degeneration, increased organ index and the presence of symptoms of toxicity
Prostate Anticancer Activity Testing α Mangostin Invitro Study on Sel DU 145 Using WST 8 Method Dewi, Rai Chika; Alaydrus, Syafika; Wahyuhandayani, Tien
Jurnal Penelitian Pendidikan IPA Vol 10 No 8 (2024): August
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i8.8517

Abstract

Prostate cancer is a cancer that has a high risk of death. Prostate cancer, specifically prostate adenocarcinoma, arises from the cells in the prostate gland or its peripheral zone. Chemotherapy, radiation therapy, and surgery are the main treatments for prostate cancer today. Empirical evidence shows that α-mangostin is used as a cancer therapy. At every stage of carcinogenesis, including cell division, proliferation, apoptosis, inflammation, and metastasis, α-mangostin can inhibit it. This study aims to evaluate the activity of α-mangostin against the DU145 prostate cancer cell line, and compare the %survival rate between cisplatin and α-mangostin. The method used is cytotoxicity testing in vitro with the WST-8 method. The research results showed that α-mangostin had an IC50 value of 16.89 ppm, in the active category, IC50 of cisplatin was 4.69 in the active category. Then statistical analysis was carried out using GraphPad Prism versi9.0.0 The results obtained were no significant differences between %survival rate cisplatin and α-mangostin at a concentration of 12.5 ppm. The conclusion of this study is The IC50 values of α-Mangostin and cisplatin against DU 145 cells were 16.89 ppm and 4.65 ppm, respectively. At a concentration of 12.5 ppm, there was no significant difference in their effects.
Anti-Cancer Activity Of The Combination Of Marine Mineral Consentrates And α Mangostin On Prostate Cancer Line DU 145 And HEK 293 By WST-8 Method Agustina, Giska Putri; Alaydrus, Syafika; Dewi, Niluh Puspita
Jurnal Penelitian Pendidikan IPA Vol 10 No 8 (2024): August
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i8.8518

Abstract

Marine mineral concentrates have good activity against normal cells, but are less effective against cancer cells. This research was carried out by combining concentrations of sea minerals with natural ingredients that have anti-cancer potential, one of which is α-mangostin. This study aims to determine the IC50 of the combination of α-mangostin, marine mineral concentrate, the combination of α-mangostin & marine mineral concentrate when compared cisplatin and evaluate the activity of α-mangostin, KML and the combination of α-mangostin and KML compared with ciplatin against the DU 145 cancer cell line and HEK 293. The method used is cytotoxicity testing using the WST-8 method. The results of the test materials were α-Mangostin 16.89 ppm, the combination of α-Mangostin-KML with a concentration of 12.5 ppm, namely 1,732 ppm, the combination of α-Mangostin-KML with a concentration of 25 ppm, namely 4,930 ppm, the combination of α-Mangostin-KML with concentration of 50 ppm 5,194 ppm, and cisplatin 4,649 ppm. The results of data analysis show significant differences for all samples. Conclusion α-Mangostin helps KML increase the cytotoxic effect on DU 145 cancer cells and sea mineral concentrate helps reduce the cytotoxic effect of α-Mangostin on normal HEK-293 cells.
Determination of specific and non-specific standardization parameters for ethanol extract of purple leaves (Graptophyllum pictum (L) Griff ) Tampang, Rivani; Alaydrus, Syafika; Dewi, Niluh Puspita; Tandi, Joni
Jurnal Penelitian Pendidikan IPA Vol 10 No 9 (2024): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i9.8812

Abstract

this study aims to determine the standardization of specific parameters (organoleptic and chemical content) and non-specific parameters (ash content, water content, drying loss, heavy metal contamination, Yeast Mold Number (AKK), microbial contamination / Total Plate Count (ALT)). The results showed that the specific parameters of the organoleptic properties of 96% ethanol extract of purple leaves (Grapthophyllum pictum (L) Griff) were black, shaped like a paste, a distinctive purple leaf odor and a bitter taste. The results of phytochemical screening of 96% purple leaf ethanol extract contained alkaloids, flavonoids, and tannins. However, the saponin test was negative for saponins. Non-specific parameters of 96% ethanol extract of cherry leaves were water content of 5.96%, total ash content of 16.86%, drying loss of 17.26%, heavy metals As and Cd were not detected, the presence of metals in Pb was 0.12 mg / kg, microbial contamination (Alt) and yeast mold numbers (Akk) were not found colonies. Based on these results, it can be concluded that the standardization test of specific and non-specific parameters, the ethanol extract of purple leaves has met the quality standards of simple drugs.
Co-Authors Agustina, Giska Putri Anggi, Viani Astria, Nani Darmayanti Darmayanti Dewi, Rai Chika Ika Yususf, Ratna Joni Tandi, Joni Kurnia Utami, Indah Lestari, Widya Ayu Magfirah, Magfirah Mariyani, Mariyani Meike Rachmawati Nadila, Nadila Niluh Puspita Dewi, Niluh Puspita Ocvinta, Sisca Polontalo, Nani Astria Puspita Dewi, Niluh Rianto Rianto Rusliyana, Rusliyana Tampang, Rivani Tuldjanah, Muthmainah Utami, Indah Kurnia Wahyuhandayani, Tien Wardani, Yunira Wawang Anwarudin