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Evi Irianti
Poltekkes Kemenkes Medan
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Journal : Jurnal Penelitian Kesehatan Suara Forikes

 1 
Pengaruh Pemberian EVOO Terhadap Berat Badan Lahir Tikus Putih (Rattus norvegicus) pada Induk Model Preeklampsia Evi Irianti; Syafruddin Ilyas; Rosidah Rosidah; Salomo Hutahaen; Ramlan Silaban
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 11 (2020): Nomor Khusus Mei-Juni 2020
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf11nk314

Abstract

Pre eclampsia is believed to be caused by a missmatch of antioxidants in the body which can be prevented by the administration of EVOO. EVOO which is proved to be rich in tocopherol which plays an important role in preventing this missmatch, thus both free radicals and antioxidants are in balanced concentration, particularly during pregnancy. This study was a laboratory based pre and post test with control group design which was conducted in total of 25 pregnant female albino rats from Sprague Dawley strain with body weight of approximately 200 grams. Samples were then grouped into P0 as control group and other 4 experimental group (P1, P2, P3, P4). Experimental group was given injection of 6% sodium chloride solution as much as 3 ml/day on the 6th until 12th day of their pregnancy and was given stimulation of acute stress on day 18th to model these groups into having pre eclampsia. All these four groups were then given EVOO on day 13th to 19th, except P1. On day 20th, all samples were executed. We found that birth weight among rats within experimental groups which were given either mild or moderate dose of EVOO showed no significant difference compared to control group, 71,43% fetus was found dead in P1, and 41,94% was found in P4. Thus, we concluded that EVOO was able to suppress free radicals and we suggested that other natural antioxidants, such as GPx, GSH and vitamin E should be furtherly investigated to see how these antioxidants work in altering the lipid peroxidation process after the administration of EVOO. Keywords: EVOO; birth weight ABSTRAK Salah satu penyebab preeklampsia adalah ketidak seimbangan antioksidan di dalam tubuh dan dapat dicegah dengan pemberian EVOO. Pemberian EVOO yang kaya akan kandungan tokoferol bertujuan untuk mencegah ketidakseimbangan antara produksi radikal bebas dan antioksidan khususnya pada kondisi hamil. Rancangan penelitian ini pre and post test with control goup design di laboratorium. Subyek tikus putih betina bunting, galur Sprague Dawley, BB ±200g. Total sampel 25 ekor terdiri atas kelompok kontrol (P0) dan 4 kelompok perlakuan sebagai model preeklampsia (P1, P2, P3, P4). Model preeklampsia dilakukan dengan injeksi NaCl 6% 3 ml/hari pada hari ke 6 – 12 periode kebuntingan dan stres akut hari ke18 sekali saja. Seluruh kelompok perlakuan diberi EVOO kecuali P1, dari hari ke 13 - 19. Hari ke 20, seluruh tikus dieksekusi. BBL kelompok perlakuan yang diberi EVOO dosis rendah maupun sedang tidak beda dengan kontrol, 71,43% fetus mati pada kelompok P1, dan 41,94% pada P4. Kesimpulan EVOO mampu menekan radikal bebas dalam darah. Disarankan untuk mengukur antioksidan alami lainnya seperti GPx, GSH serta vitamin E untuk mengetahui peranan dalam mereduksi peroksida lemak setelah pemberian EVOO. Kata kunci: EVOO; berat badan lahir
Gel Daun Sirih Merah (Piper crocatum Ruiz & Pav) 15% Efektif dalam Mempercepat Penyembuhan Luka Perineum pada Tikus Putih Betina (Rattusnorvegicus) Galur Wistar Yusniar Siregar; Rismahara Lubis; Evi Irianti
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 13, No 3 (2022): Juli 2022
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf.v13i3.2219

Abstract

Perineal wounds if not treated properly can lead to infection. Several ways to treat perineal wounds due to childbirth have been widely studied, one of which is by using herbal plants such as red sirin leaves which are known to have antiseptic and antibacterial effects. The purpose of this study was to analyze the difference in the effectiveness of 15% red betel leaf gel and 10% Povidone Iodine ointment on perineal wound healing in female white wistar rats. This type of research was a true experiment with a posttest only design with a control group. The population in this study were pregnant female white rats with the Wistar strain, which gave birth several times or for the first time and were 10 weeks old. The research sample was calculated using the Federer formula, in order to obtain a minimum sample size of 10 in each group consisting of 3 groups. Data analysis was carried out by ANOVA test, followed by Pos Hoc test. The results showed that the drying of wounds given 15% betel leaf gel was 3 days, while in the group given 10% povidone iodine ointment it was 8 days. The duration of wound healing (based on the unification of wound tissue) for the group given 15% red betel leaf gel was 6 days, while the group given 10% povidone odine ointment was 10 days. The results of statistical tests showed p value <0.05, so there was a difference in the speed of wound healing from the two groups. Furthermore, it was concluded that 15% red betel leaf gel was more effective for wound healing than 10% Povidone Iodine ointment.Keywords: red betel leaf; povidone-iodine; perineal woundABSTRAK Luka perineum jika tidak ditangani dengan baik dapat menyebabkan infeksi. Beberapa cara untuk mengobati luka perineum akibat persalinan telah banyak diteliti, salah satunya adalah dengan menggunakan tanaman herbal seperti daun sirin merah yang diketahui memiliki efek antiseptik dan antibakteri. Tujuan dari penelitian ini adalah untuk menganalisis perbedaan efektivitas 15% gel daun sirih merah dan salep Povidone Iodine 10% pada penyembuhan luka perineal pada tikus wistar putih betina. Jenis penelitian ini adalah eksperimen murni dengan desain posttest only with control group. Populasi dalam penelitian ini adalah tikus putih betina bunting dengan strain Wistar, yang melahirkan beberapa kali atau pertama kali dan berumur ≥10 minggu. Sampel penelitian dihitung menggunakan rumus Federer, sehingga diperoleh ukuran sampel minimal yaitu 10 ekor di setiap kelompok yang terdiri atas 3 kelompok. Analisis data dilakukan dengan uji ANOVA, dilanjutkan dengan tes Pos Hoc. Hasil penelitian menunjukkan bahwa pengeringan luka yang diberi 15% gel daun sirih adalah 3 hari, sedangkan pada kelompok yang diberi salep povidone iodine 10% adalah 8 hari. Lama penyembuhan luka (berdasarkan penyatuan jaringan luka) kemponpok yang diberikan gel daun sirih merah 15% adalah 6 hari, sedangkan kelompok yang diberi salep povidone odine 10% adalah 10 hari. Hasil uji statistik menunjukkan nilai p <0,05, sehingga ada perbedaan kecepatan penyembuhan luka dari kedua kelompok. Selanjutnya disimpulkan bahwa gel daun sirih merah 15% lebih efektif untuk penyembuhan luka daripada salep Povidone Iodine 10%.Kata kunci: daun sirih merah; povidone iodine; luka perineum
Co-Authors Arief Budiono Atik Badiah Dini Lestrina Heru Santoso Wahito Nugroho I Putu Suiraoka Ida Nurhayati ilyas - ibrahim Koekoeh Hardjito MAHDIAH Mangkuji, Betty MELVA SIMATUPANG Nasution, Zuraidah Oslida Martony Pius Selasa Putri Ardiana Rizki Ramlan Silaban Ratna Zahara Rismahara Lubis Rosidah, Rosidah Sahrir Sillehu Salomo Hutahaen Setiawan Sunarto, Sunarto Suparji Suparji Suswati Syafruddin Ilyas Tetty Herta Doloksaribu Yulina Dwi Hastuty Yusniar Siregar