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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Budimas : Jurnal Pengabdian Masyarakat MEDICA (International Medical Scientific Journal)
Indrawati, Ratih
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Journal : MEDICA (International Medical Scientific Journal)

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The Relationship Between Anti-Tuberculosis Drug Therapy and Uric Acid and Creatinine Levels in Tuberculosis Patients in Kayong Utara District Selvianty, Selvianty; Indrawati, Ratih; Salim, Maulidiyah
MEDICA (International Medical Scientific Journal) Vol. 7 No. 2 (2025): MEDICA (Internasional Medical Scientific Journal)
Publisher : Borneo Scientific Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53770/medica.v7i2.513

Abstract

Pulmonary tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis. TB treatment involves five essential drugs: isoniazid, streptomycin, ethambutol, rifampicin, and pyrazinamide. Among these, pyrazinamide and ethambutol are known to potentially increase uric acid and creatinine levels as side effects. This study aimed to examine the relationship between anti-TB drug (OAT) therapy and levels of uric acid and creatinine in TB patients in Kayong Utara District. Using a cross-sectional design and purposive sampling, data were collected from 31 TB patients across three community health centers with the highest TB incidence. Results showed that 54.8% of patients had elevated uric acid levels, while 45.2% had normal levels. For creatinine, 93.5% had normal levels, and 6.5% had elevated levels. Chi-square analysis indicated a significant association between OAT therapy and uric acid levels (p = 0.045), but no significant relationship was found with creatinine levels (p = 1.000). These findings suggest that OAT therapy may affect uric acid levels in TB patients, highlighting the need for monitoring during treatment.  
Co-Authors Ari Widiyantoro Hendra Budi Sungkawa, Hendra Budi Ihsan, Bagus Muhammad Maulidiyah Salim Ratnawaty, Gervacia Jenny Selvianty, Selvianty