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All Journal Buletin Farmatera FaST : Jurnal Sains dan Teknologi Bhamada: Jurnal Ilmu dan Teknologi Kesehatan (E-Journal) Jurnal Riset Kefarmasian Indonesia Jurnal Empathy Pengabdian Kepada Masyarakat Bioscientist : Jurnal Ilmiah Biologi Jurnal Farmasi dan Sains Indonesia (JFSI) Jurnal Pengabdian Masyarakat (ABDIRA) Journal of Science and Technology Research for Pharmacy Gemakes: Jurnal Pengabdian Kepada Masyarakat Jurnal Ilmiah Kesehatan Parapemikir Jurnal Ilmiah Farmasi Jurnal Sains dan Kesehatan Bhamada: Jurnal Ilmu dan Teknologi Kesehatan (E-Journal)
Ayuningtyas, Nurista Dida
Program Studi Sarjana Farmasi, Universitas Pelita Harapan, Tangerang, Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Journal : Jurnal Farmasi dan Sains Indonesia (JFSI)

 1 
FORMULASI PRODUK KOSMETIKA HALAL SUNSCREEN KRIM EKSTRAK BIJI LAMTORO (Leucaena leucocephala L) Elsa Zyuri Anggraini; Fithria Nur Annisa; Silmi Mey Aryani; Nurista Dida Ayuningtyas
Jurnal Farmasi & Sains Indonesia Vol 2 No 1 (2019)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

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Latar Belakang : Kosmetika halal sangat dibutuhkan oleh konsumen Indonesia yang mayoritas beragama muslim. Krim tabir surya merupakan kosmetik yang sering digunakan karena tingginya bahaya sinar UV A dan UV B dari sinar matahari dapat mengakibatkan penuaan dini pada kulit seperti timbulnya bintik-bintik hitam sampai dengan keriput dan kanker kulit. Ekstrak biji lamtoro memiliki kandungan flavonoid yang dapat berfungsi sebagai antioksidan. Tujuan : penelitian ini adalah pembuatan krim ekstrak biji lamtoro, pengujian efektifitas tabir surya dengan penentuan nilai SPF, %TE dan %TP Metode : pembuatan krim ekstrak biji lamtoro dilakukan dengan emulgator span 80, tween 80 dan asam stearat. Konsentrasi ekstrak biji lamtoro yang digunakan sebanyak 3%, 5%, dan 7%. Evaluasi formula yang dilakukan meliputi organoleptis, homogenitas, daya sebar, daya lekat dan pH. Formula dilakukan pengujian nilai SPF, %TE, dan %TP Hasil : hasil organoleptis berbentuk setengah padat, berwarna hijau, berbau aromatis; krim homogen. Hasil nilai SPF krim ekstrak biji lamtoro secara berturut-turut yaitu 4,90; 6,33; dan 7,09. Nilai %TE krim 26,03%; 16,29%; dan 14,16%. Hasil nilai %TP krim 38,52%; 28,02%, dan 26,66%.
FORMULASI EMULGEL EKSTRAK ETANOL 96% MINYAK BIJI MAHONI (Swietenia mahagoni L.) SEBAGAI ANTIBAKTERI PADA BAKTERI STAPHYLOCOCCUS AUREUS Mega Eka Yuniyasanti; Nurista Dida Ayuningtyas; Yahya Febrianto
Jurnal Farmasi & Sains Indonesia Vol 2 No 1 (2019)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

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Mahoni (Swietenia mahagoni L.) merupakan tanaman yang termasuk dalam golongan tanaman obat. Bagian dari tanaman yang sering dipakai sebagai obat oleh masyarakat adalah biji. Biji mahoni mempunyai kandungan kimia alkaloid, saponin, dan flavonoid. Salah satu senyawa fitokimia yang penting dan memiliki potensi sebagai antibakteri adalah flavonoid. Tujuan dari penelitian ini adalah untuk mengetahui aktivitas antibakteri dari emulgel ekstrak dan ekstrak etanol 96% biji mahoni terhadap bakteri Staphylococcus aureus dan uji sifat fisik pada sediaan emulgel. Pada pembuatan emulgel dibuat perbandingan konsentrasi ekstrak etanol 96% minyak biji mahoni dan gelling agent carbhopol 934 dan HPMC. Uji aktivitas antibakteri dilakukan dengan metode difusi sumuran dan bakteri Staphylococcus aureus. Evaluasi antibakteri dilakukan pada ekstrak etanol 96% minyak biji mahoni (30%, 40%, 50%) dan sediaan emulgel (30%, 35%, 50%). Evaluasi sifat fisik formula emulgel meliputi uji organoleptis, uji homogenitas, uji daya lekat, uji pH, uji viskositas, dan uji daya sebar. Hasil penelitian menunjukan bahwa daya hambat antibakteri pada bakteri staphylococcus aureus ekstrak etanol 96% minyak biji mahoni (30%, 40%, 50%) secara berturut-turut yaitu 0,67cm ;1,1cm ; 1,53 cm. Sedangkan pada sediaan emulgel (30%, 35%, 40%) secara berturut-turut yaitu 0,5 cm ; 0,76 cm ; 1 cm. Hasil evaluasi sifat fisik formula emulgel secara organoleptis berwarna coklat, berbentuk semi padat, berbau khas biji mahoni, dan berasa dingin dikulit; tidak homogen; uji daya lekat sebesar 27,56 - 35,22 detik uji pH yang didapat 8,35 -8,75; uji viskositas yang didapat 86,67 -133,33 dPas; dan uji daya sebar didapat hasil 19,04 – 26,11 cm2.
PENETAPAN KADAR TOTAL FLAVONOID EKSTRAK ETANOL BIJI MAHONI (Swietenia mahagoni L.) DENGAN METODE SPEKTROFOTOMETRI UV-VIS Nurista Dida Ayuningtyas; Felisia Bani
Jurnal Farmasi & Sains Indonesia Vol 1 No 2 (2018)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

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Latar Belakang : Biji mahoni telah lama dikenal untuk berbagai pengobatan salah satunya untuk menurunkan kadar gula darah. Biji mahoni mengandung fitokonstituen seperti golongan limonoid, kumarin, ester asam lemak, steroid, polifenol, esensial oil, tanin, dan flavonoid. Tujuan Penelitian : Penelitian ini bertujuan untuk mengetahui kadar total flavonoid dalam ekstrak biji mahoni. Metode Penelitian : Proses ekstraksi dilakukan dengan metode maserasi dengan pelarut etanol 96% untuk menarik senyawa kimia di dalam ekstrak. Ekstrak yang diperoleh dikarakterisasi organoleptis, pH dan viskositas. Analisis kandungan kimia ekstrak secara kualitatif menggunakan pereaksi warna untuk mengetahui adanya alkaloid, tanin, flavonoid, dan saponin dalam ekstrak. Pengukuran kadar total flavonoid ekstrak biji mahoni secara kuantitatif menggunakan metode Spektrofotometri UV-Vis. Baku standar yang digunakan yaitu kuersetin yang merupakan flavonoid golongan flavonol. Pereaksi yang digunakan untuk uji total flavonoid yaitu AlCl3 dan Na. asetat anhidra, pengukuran total flavonoid dilakukan pada panjang gelombang 414,5 nm dan waktu inkubasi 16 menit. Hasil : Ekstrak yang diperoleh berbentuk cair, berbau pahit menyengat, dan berwarna coklat tua. pH ekstrak 5,61 dan viskositas ekstrak 20 cPs. Pada uji kualitatif didapatkan ekstrak biji mahoni mengandung alkaloid, tanin, dan flavonoid. Analisis kuantitatif total flavonoid ekstrak biji mahoni diperoleh kadar senyawa total flavonoid sebesar 258,85 mcg/gram ekstrak.
FORMULASI SABUN TRANSPARAN MENGGUNAKAN KOMBINASI MADU DAN DAUN TEH HIJAU (Camelia sinensis L.) Nurista Dida Ayuningtyas; Agustina Putri Pitarisa Sudarsono; Tri Mulyani
Jurnal Farmasi & Sains Indonesia Vol 1 No 1 (2018)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

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Madu merupakan substansi alam yang diproduksi oleh lebah madu dan berasal dari nektar bunga atau sekret. Madu dikenal cairan menyehatkan dan berkhasiat yaitu sebagai ekspektoran dan pembersih luka pada kulit maupun bisul. Teh hijau (Camellia sinensis L.) merupakan salah satu jenis tanaman herbal, dapat dibudidayakan di Asia Tenggara sebagai bahan baku pembuatan obat tradisional (herbal medicine). Khasiat teh bagi kecantikan untuk menghaluskan rambut, dan sebagai masker untuk merawat wajah. Penelitian ini bertujuan untuk mengetahui formulasi sabun transparan menggunakan kombinasi madu dan daun teh hijau menghasilkan penampilan fisik yang cukup baik dari 12 formula. Penelitian ini merupakan penelitian eksperimental yaitu formulasi sabun transparan yang menggunakan zat aktif madu dan daun teh hijau dengan cara mengoptimasi komponen asam stearat dan TEA sebagai emulgator. Pengujian yang dilakukan yaitu uji organoleptis, uji pembentuk busa, uji pH, uji kadar air, dan uji kesukaan pada 20 responden. Data uji pembentukan busa, uji pH, uji kadar air, dan uji kesukaan diuji normalitas dan homogenitasnya. Uji statistik kemudian dilanjutkan dengan uji parametrik (Anova) ataupun non parametrik (Kruskal-Wallis). Hasil penelitian menunjukkan pada uji organoleptis diperoleh sabun transparan berwarna putih sampai kuning kecoklatan dan homogen. Hasil statistik normalitas pembentuk busa diperoleh nilai p<0,05 yang berarti data yang diperoleh tidak homogen, sehingga analisis statistik dilanjutkan Kruskal-Wallis . Hasil statistik uji pH yang didapatkan p 3,93; uji kadar air nilai p 1,00; uji kesukaan p 9,88 (p > 0,05) artinya tidak ada perbedaan yang signifikan antar tiap formula, sedangkan uji pembentuk busa nilai p 0,03 (p < 0,05) artinya ada perbedaan antar tiap formula.
Formulasi Orally Disintegration Tablet (ODT) Candesartan Cilexetil Dengan Croscarmellose Sodium dan Crospovidone Sebagai Superdisintegrant Nurista Dida Ayuningtyas; Yahya Febrianto; Tutut Lutfi
Jurnal Farmasi & Sains Indonesia Vol 4 No 1 (2021)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.v4i1.64

Abstract

Candesartan cilexetil is a group of selective AT1 hypertension drugs (angiotensin II receptor antagonist 1). The drawback of candesartan cilexetil in conventional tablets is that it cannot be used for geriatric patients who have difficulty swallowing tablets, patients with developmental disorders of the muscle and nervous system (tremors), and in schizophrenic patients that lead to poor patient compliance, so to overcome this problem alternative dosage forms are made new namely ODT candesartan cilexetil. This study aims to determine the effect of the combination of superdesintegrant croscarmellose sodium and crospovidone on the quality test of the physical properties of tablets. Candesartan cilexetil ODT tablets bolted by direct compression method with variations in levels of superdesintegrant croscarmellose sodium and crospovidone 2: 3,5%, 2,75: 2,75%, 5: 0,5%, 4,25: 1,25 %, 3,5: 2%. Tests conducted to determine the physical quality of candesartan cilexetil ODT, namely organoleptic, weight uniformity, size uniformity, hardness, brittleness, disintegration time, wetting time and water absorption ratio. Showed an increase in the use of crospovidone (5%) and a decrease in croscarmellose sodium (0.5%) had a greater effect on the disintegration time because it could make the tablet porous when in contact with water so that it would accelerate the disintegration time of 29.167 seconds and increase the speed of wetting the tablets 25.33 seconds. The combination of superdisintegrant croscarmellose sodium and crospovidone (0.5: 5%) in formula 3 can provide physical properties that meet the best quality ODT requirements for candesartan cilexetil.
Formulasi Sediaan Pasta Gigi Gel Minyak Atsiri Daun Jeruk Nipis (Citrus Aurantifolia) Dengan Variasi Konsentrasi Carbomer 940 Sebagai Basis Gelling Agent Nurista Dida Ayuningtyas; Agustina Putri Pitarisa Sudarsono; Anastasiya Sisca Yuswanti
Jurnal Farmasi & Sains Indonesia Vol 4 No 2 (2021)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol4no2p98-103

Abstract

Background : Lime leaves contain flavonoids, tannins, and saponins. This content is known to have activity as an antibacterial and protective of gums and teeth. Based on these activities, lime leaves can be developed as an active ingredient in gel toothpaste preparations. In the manufacture of gel toothpaste, the component that plays an important role is the gelling agent. Purpose: In this study, a variation of the gelling agent Carbomer 940 will be used to make a gel toothpaste with lime leaf extract. Methods: The independent variable used is Carbomer 940 with a variation of 3 formulas, namely 0.6%; 1.2%; and 1.8%. The evaluations carried out on gel toothpaste were organoleptic, homogeneity, pH, adhesion, spreadability and pH. Data analysis was carried out with SPSS software to see the differences between each formula. Results: The results showed that the formula 1-3 was homogeneous with a clear, homogeneous color, and a characteristic smell of menthol with a pH range of 5.85-7.49; spreading area 20.60-29.91 cm2, adhesion 6.01-35.1 seconds. The results of statistical tests with one-way ANOVA obtained a significant difference between each formula.
PENGGUNAAN GLUKOMANAN DARI UMBI PORANG (Amorphophallus oncophyllus Pr.) SEBAGAI BIODEGRADABLE FILM DENGAN PENAMBAHAN SORBITOL DAN GLISEROL SEBAGAI PLASTICIZER Sudarsono, Agustina Putri Pitarisa; Sari, Clara Evita; Ayuningtyas, Nurista Dida
Jurnal Farmasi & Sains Indonesia Vol 6 No 1 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no1p133-138

Abstract

Plastic waste that is not handled properly will cause disaster. Glucomannan is a type of hemicellulose polysaccharide from porang flour with an extraction method to extract glucomannan compounds in porang flour. The addition of plasticizer as an additive is useful for forming a film layer in this study. Biodegradable film is a type of film coating as a food wrapper that is environmentally friendly and safe to eat which can be decomposed by microorganisms made from processed starch compounds. Porang tubers have the potential as a biodegradable film material with high glucomannan content. This study aims to make a biodegradable film from Porang tubers and to determine the performance of sorbitol and glycerol as plasticizers. The research method begins with the extraction of porang flour with 50% and 80% ethanol twice in a ratio (1:6) stirred using a homogenizer for 30 minutes, then to form a biodegradable film with the addition of sorbitol and glycerol plasticizers using a magnetic stirrer for 45 minutes. minutes with a stirring temperature of 80ºC followed by an evaluation of the biodegradable film characterization, swelling test, FTIR test, biodegradation test using One Way Anova statistical analysis. The results showed that the biodegradable film with the addition of 10% glycerol plasticizer showed good results with the characteristics of the biofilm being slightly viscous, the evaluation degree of swelling was 76.13%, degraded for 20 days.
Formulasi Dan Evaluasi Fisik Sediaan Shaving Cream Ekstrak Rimpang Kunyit (Curcuma longa Linn.) Jesica, Imelda Angie; Maillinda, Putri; Wijaya, Octa Vanessia; Mungkur, Theresia Rohani; Lisangan, Angelyn Jessica; Ayuningtyas, Nurista Dida
Jurnal Farmasi & Sains Indonesia Vol 8 No 1 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no1p95-102

Abstract

The hair follicle is an unavoidable part of the skin and its growth can make some people feel uncomfortable. The use of shaving cream can help the shaving process, but daily use can cause the skin to become dry. Turmeric (Curcuma longa Linn.) is often used in cosmetics because it has antioxidant and anti-inflammatory properties that maintain moisture and reduce skin redness. Curcumin in turmeric also has antiandrogenic effects that can remove fine hair. This study uses curcumin contained in turmeric as the active substance of shaving cream which has a concentration of 0.1%; 0.25%; 0.5%. Antioxidant activity testing was carried out with DPPH radical scavenging (2.2-diphenyl-1-picylhydrazyl) resulting in IC50 on turmeric extract of 94.63 ppm. The results of phytochemical screening on extracts are known to contain secondary metabolites that were successfully analyzed were Flavonoids, Alkaloids, Triterpenoids, Tannins, Anthraquinones, and Polyphenols. The physical evaluation of turmeric rhizome extract shaving cream preparation meets the requirements, except for the pH test. The results obtained IC50 values of turmeric rhizome extract shaving cream are 1377.78 ppm in F1; 1591.55 ppm in F2; and 1637.93 ppm in F3, so it is still classified as very weak and less effective. In the skin moisture test on 10 respondents with 5 women and 5 men there was an increase in % moisture after the use of shaving cream on days 1, 3, 5 and 7.
Analisis Hubungan Tingkat Pengetahuan Tentang COVID-19 Dan Penggunaan Imunbooster Karyawan PT Phapros Tbk Semarang Suwarni, Sri; Aryanti, Destryana; Ayuningtyas, Nurista Dida; Ikhsan, Muhammad; Wulandari, Ratna
Jurnal Farmasi & Sains Indonesia Vol 5 No 1 (2022)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol5no1p76-84

Abstract

Corona virus Disease 2019 (COVID-19) as a new type of disease that has never been identified before in humans with signs and symptoms including symptoms of acute respiratory disorders such as fever, cough and shortness of breath. COVID-19 can be prevented by improving the body's resistance to respiratory infections. Knowledge is an important domain for the formation of a person's behavior because actions based on knowledge will be more important than actions or behaviors that are not based on knowledge. This study aims to determine the relationship between the level of knowledge about COVID-19 and the use of Immunbooster as a form of infection prevention for employees at PT Phapros Tbk. The research method carried out was descriptive-analytic with a crosssectional research design. The sample in this study was employees at PT Phapros Tbk who met the inclusion and exclusion criteria based on purposive sampling method. For data in this study using primary data from research questionnaires filled out online. Data analysis of the results of the study was carried out using Spearman's rank correlation test. The results showed that there is a relationship between the level of knowledge of COVID-19 and the use of Immunbooster in employees of PT Phapros Tbk Semarang. as evidenced by the spearman's test value obtained value of 0.000 <0.050. The strength of the relationship is moderate as seen from the correlation coefficient value of 0.589 and the test results produce a correlation coefficient value has a positive direction, so it can be said that if COVID-19 knowledge increases, the behavior of using immunbooster will also increase or get better.
Co-Authors Agustina Putri Pitarisa S Agustina Putri Pitarisa Sudarsono Agustina Putri Pitarisa Sudarsono Anastasiya Sisca Yuswanti Arianditha Pranasti, Ernestine Aris Widayati Aruan, Maroloan Aryanti, Destryana Ayu Ina Solichah Azizah Yuka Hapsari Benny Setiawan, Benny Destryana Aryanti Elsa Zyuri Anggraini Felisia Bani Felisia Bani Ferika Indrasari Fithria Nur Annisa Hardy, Junius Hartanti, Yesiska Kristina Ismena, Arnita Vania Naomi Jesica, Imelda Angie Lisangan, Angelyn Jessica Maillinda, Putri Mega Eka Yuniyasanti Metrikana Novembrina Muhammad Ikhsan Muhammad Ikhsan Mungkur, Theresia Rohani Pramitaningastuti, Anastasia S Pramitaningastuti, Anastasia Setyopuspito Prasetyo, Alno Ratna Wulandari Ratna Wulandari Reni Cyrena Santoso, Feronia Rizky Nur Fadhilah Rizqi Adi Irfani Rosa, Dela Sandi Mahesa Yudhantara Santoso, Sherly Angelina Sari, Clara Evita Silmi Mey Aryani Silmi Mey Aryani Sri Suwarni Sri Suwarni Sudarsono, Agustina Putri Pitarisa Tri Mulyani Tri Mulyani Tri Subekti Tutut Lutfi Widyawati, Erni Wijaya, Octa Vanessia Yahya Febrianto Yahya Febrianto