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All Journal Jurnal Farmasi dan Sains Indonesia (JFSI) Jurnal Pengabdian Masyarakat (ABDIRA) JUMANTIK (Jurnal Ilmiah Penelitian Kesehatan) Indonesian Journal on Medical Science (IJMS) Jurnal Sains dan Kesehatan
Sawal, Rizky Ardian Hartanto
Sekolah Tinggi Ilmu Farmasi Nusaputera
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Journal : Jurnal Farmasi dan Sains Indonesia (JFSI)

 1 
PENGARUH EKSTRAK ETANOL DAN FRAKSI n-HEKSANA BUAH TAKOKAK (Solanum torvum Sw.) TERHADAP RESPON IMUN SELULER PADA MENCIT PUTIH JANTAN Balb/c DENGAN UJI DELAYED-TYPE HYPERSENSITIVITY (DTH) Rizky Ardian Hartanto Sawal; Jason Merari Peranginangin; Reslely Harjanti
Jurnal Farmasi & Sains Indonesia Vol 2 No 1 (2019)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

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Abstract

Buah takokak (Solanum torvum Sw.) mengandung senyawa flavonoid dan steroid yang diharapkan mampu memodulasi sistem imun tubuh. Penelitian ini dilakukan untuk mengetahui dan membuktikan pengaruh ekstrak etanol dan fraksi n-heksana buah takokak dan dosis efektif terhadap respon imun seluler dengan parameter perubahan ketebalan kaki kanan mencit. Penelitian ini menggunakan sebanyak 45 ekor hewan uji mencit dan dibagi dalam 9 kelompok yaitu kontrol negatif (CMC 0,5%), kontrol positif imunostimulan (stimuno), kontrol positif imunosupresan, dosis ekstrak etanol buah takokak 75 mg/kg BB, 150 mg/kg BB, dan 400 mg/kg BB, dan dosis fraksi n-heksana buah takokak 20 mg/kg BB, 40 mg/kg BB, dan 80 mg/kg BB. Setiap mencit disensitisasikan dengan SDMD 20% 0,1 ml secara i.p. kemudian diberikan perlakuan sesuai dengan kelompok masing-masing selama 7 hari. Pada hari ke-6 ketebalan kaki kanan mencit diukur dengan menggunakan jangka sorong lalu diinjeksi dengan SDMD 1% 0,02 ml secara s.c. pada telapak kaki kanan. Ketebalan kaki kanan mencit diukur kembali setelah 24 jam untuk mengetahui respon DTH. Data yang diperoleh dianalisis menggunakan one-way ANOVA. Hasil penelitian menunjukkan bahwa ekstrak etanol buah takokak dengan dosis 150 mg/kg BB dan 300 mg/kg BB dapat meningkatkan sistem imun seluler masing-masing sebesar 55,41 ± 2,5790 dan 57,51 ± 3,6908. Fraksi n-heksana buah takokak dengan dosis 20 mg/kg BB, 40 mg/kg BB, dan 80 mg/kg BB mampu menekan respon imun seluler masing-masing sebesar 30,42 ± 4,7043, 30,03 ± 5,0101 dan 25,72 ± 6,1311.
PENETAPAN KADAR SENYAWA FLAVONOID TOTAL DALAM FRAKSI-FRAKSI SIRIH MERAH (Piper Crocatum Ruiz & Pav) Rizky Ardian Hartanto Sawal; Windarsih Sutrisna
Jurnal Farmasi & Sains Indonesia Vol 2 No 2 (2019)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

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Sirih merah adalah salah satu tumbuhan obat yang kini banyak juga ditanam sebagai tanaman hias. Penggunaan sirih merah secara tradisional dimanfaatkan dalam menyembuhkan penyakit seperti sariawan dan sakit gigi. Tujuan peneltian ini adalah untuk melakukan penetapan kadar flavonoid total dalam fraksi-fraksi daun sirih merah (Piper Crocatum Ruiz &Pav). Metode penelitian yang digunakan untuk pembuatan ekstrak adalah remaserasi menggunakan pelarut etanol 96%, fraksinasi dengan cair-cai menggunakan n-Heksana, etil asetat dan air. Analisa data pada penelitian ini menggunakan metode spektrofotometri untuk mengetahui kadar kandungan flavonoid total dalam fraksi-fraksi sirih merah (Piper Crocatum Ruiz & Pav). Hasil spektrofotometri dengan menggunakkan panjang gelombang430,1 nm, kadar flavonoid tertinggi berada pada kelompok A sebesar 182,98 mg QE/g ekstrak mempunyai ppm 19,03. Kelompok B sebesar 133,84 mg QE/g ekstrak dengan ppm 19,03 dan kelompok C sebesar 64,77 mg QE/g ekstrak dengan ppm 6,737.
Aktivitas Ekstrak Etanol Daun Akar Kucing (Acalypha indica L.) Sebagai Pengawet Alami Pada Buah Tomat (Lycopersium esculentum Mill.) Solichah, Ayu Ina; Sawal, Rizky Ardian Hartanto; Auliya, Fitri
Jurnal Farmasi & Sains Indonesia Vol 6 No 1 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no1p120-125

Abstract

The presence of preservatives in food is a common thing to extend the shelf life of foods. The bad effects appliying chemical preservatives cause both environmental pollution and health disturbing. Consuming chemical preservatives for a long time will will cause cancer. Natural preservatives is needed to reducing the bad effects. One of the Plants can be applied as natural preservatives is cat root leaves (Acalypha indica L. The study aims were to determine the activity and effective concentration of cat root leaf extract as a natural preservative on tomatoes and to identify the its phytochemical content. Activity of cat root leaf extract as a preservative was subjected by organoleptic, meanwhile the phytochemical content by tube-test. The results showed 8% cat root leaf extract effective as natural preservative according to organoleptic observation with observed time for 20 days. The result of tube-test showed cat root leaf extract contain compounds likes alkaloid, flavonoid, saponin, tannin, and terpenoid.
Evaluasi Potensi Ekstrak Etanol Daun Kencur (Kaempferia galanga L.) sebagai Antimikroba terhadap Propionibacterium acnes melalui Teknik Disk Diffusion Sawal, Rizky Ardian Hartanto; Rahayu, Noel Asri
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p193-199

Abstract

The galangal plant, which many people still don't know about, has a variety of interesting benefits. Among other things, kencur leaves contain chemical compounds such as flavonoids and essential oils which have antimicrobial properties. This study aims to activate the antibacterial activity of ethanol extract of kencur leaves against Propionibacterium acnes, as well as to measure how effective it is at different concentrations. The extraction process uses 96% ethanol solvent with the Remaceration method, which is then accompanied by phytochemical screening and TLC tests to strengthen the results. Antibacterial activity tests were carried out using the disc diffusion method at concentrations of 0.3%, 0.6%, 1.2% and 2.4%. The results show the inhibition zone at each concentration, namely 6.86 mm, 8.4 mm, 9.8 mm, and 10.96 mm. Phytochemical analysis identified secondary metabolite compounds such as tannins, saponins and flavonoids with Rf values of 0.925 each; 0.825; and 0.8125. Statistical analysis showed a significant difference between concentrations of 0.3% and 1.2%.
Perbandingan Kadar Total Flavonoid Ekstrak Daun Ketapang (Terminalia catappa L) berdasarkan Kekeringan Simplisia dengan Metode Spektrofotometri UV-Vis Pratiwi, Anastasia Eka; Bulu, Atalia Tamo Ina; Sawal, Rizky Ardian Hartanto; Pitarisa, Agustina Putri
Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no1p203-209

Abstract

Traditional treatment remains one of the widely used treatment methods to this day. One of the plants with potential as conventional medicine is the Ketapang leaf (Terminalia catappa L), which belongs to the Combretaceae family. Ketapang leaves contain various compounds such as flavonoids, alkaloids, tannins, and saponins, with flavonoids known for their high antioxidant properties. This study aims to compare the total flavonoid content in fresh and dried Ketapang leaf extracts. The extraction method used is maceration with 96% ethanol solvent. Evaluation includes organoleptic tests, moisture content, drying shrinkage, phytochemical screening, and thin-layer chromatography (TLC). Total flavonoid content testing is conducted using the colorimetric method with UV-Vis spectrophotometry at a wavelength of 430 nm, with quercetin as the standard. The results show that the yield of fresh Ketapang leaves was 8.74% w/w, while dried Ketapang leaves were 8.40% w/w. In the TLC tested, the Rf values of fresh and dried Ketapang leaf extracts were 0.95 and 0.94, respectively. The total flavonoid content in fresh Ketapang leaf extract was 24.19 mgQE/gram, while for dried Ketapang leaf extract it was 16.84 mgQE/gram. Statistical analysis with an independent sample t-test showed a significant difference (p<0.05) between fresh and dried Ketapang leaf extracts.
Co-Authors Agustina Putri Pitarisa Anastasia Eka Pratiwi Atalia Tamo Ina Bulu Auliya, Fitri Ayu Ina Solichah Bulu, Atalia Tamo Ina Dwi Wulandari Ferika Indrasari Fitri Auliya Jason Merari Peranginangin Kamila, Iffa Margareta Retno Priamsari Metrikana Novembrina Noel Asri Rahayu Pitarisa, Agustina Putri Pratiwi, Anastasia Eka Priamsari, Margaretha Retno Rahayu, Noel Asri Reslely Harjanti Solichah, Ayu Ina Windarsih Sutrisna Windarsih Sutrisna Yahya Febrianto Yithro Serang