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Journal : Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan

UJI EFEKTIVITAS ANTIBAKTERI ESKTRAK ETIL ASETAT BAWANG DAYAK (Eleutherine palmifolia Merr) TERHADAP STAPHYLOCOCCUS AUREUS DENGAN METODE SUMURAN Fitriyanti Fitriyanti; Abdurrazaq Abdurrazaq; Muhammad Nazarudin
Jurnal Ilmiah Manuntung Vol 5 No 2 (2019): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v5i2.278

Abstract

Dayak onion (Eleutherine palmifolia Merr.) is a multifunctional medicinal plant for various diseases, one of which is an antibacterial. Dayak Onions (E. palmifolia Merr.) contains an alkaloid, flavonoid, triterpenoid, and saponin compound which has antibacterial properties. This study aims to determine the effect of the ethyl acetate extract of Dayak Onion tubers inhibits the growth of Staphylococcus aureus bacteria. Dayak onion tuber was extracted using ethyl acetate solvent by the maceration method until thick extract was obtained. The concentration extract used were 30 mg/ml;15 mg/ml;7,5 mg/ml;3,75 mg/ml; 1,875 mg/ml; and 0,9375 mg/ml tested for antibacterial effectivity against Staphylococcus aureus using Mueller Hinton Agar (MHA) with the wells method. The result showed that the ethyl acetate of Dayak onion with MEC (Minimum effective concentration) 3,75 mg/ml obtained inhibition zone of 10,367 mm while at the highest concentration of 30 mg/ml had the best antibacterial effectiveness. The effective concentration of ethyl acetate onion of Dayak tuber which is 30 mg/ml obtained inhibition zone of 18,404 mm even in the moderate category.
PENGEMBANGAN MIKROEMULSI DARI EKSTRAK ETANOL 96% KULIT BATANG BALIK ANGIN (Alphitonia incana (Roxb.) Teijsm & Binn. Ex Kurz) Bin Jamaludin, Wahyudin; Muhammad Hidayattullah; Muammaroh; Fitriyanti; Marlia Fatwa
Jurnal Ilmiah Manuntung Vol 11 No 1 (2025): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v11i1.881

Abstract

The 96% ethanol extract of Balik angin stem bark contains secondary metabolite compounds that have potential antioxidant activity with a value of 37.00 ± 1.46µg/ml (bpj), the potential for use can be maximized in microemulsion preparations. In microemulsions, one of the ingredients that can affect the stability of the microemulsion is a cosurfactant which can affect the globule size and polydispersity index. Microemulsions were formulated by varying the type and concentration of cosurfactants to determine the optimal formula based on the test parameters of physical characteristics and stability of the preparation. The method used in this research is experimental and in the manufacture of microemulsions, namely the spontaneous emulsification method. The test results show that all formulas in the organoleptic test are clear except F1, the Tyndall test can transmit light, the pH value is 5.4 -5.6, the microemulsion type is M/A, the specific gravity is 1.038-1.064, the viscosity value is less than 200 cPs and the percent transmittance obtained ranges from 90-97%. The globule size test of F2 to F6 (55.03-1045) and the polydispersity index test of F2 to F6 (0.277-0.827), but the results were not detected in F1. The results of statistical tests on pH and specific gravity tests obtained p-value (>0.05), F3 viscosity test obtained p-value (<0.05) and T% test on F1, F4, and F5 obtained p-value (<0.05) so it can be concluded that microemulsion preparations with variations in the type and concentration of cosurfactants have an influence on physical characteristics and stability, and the most optimal formula is F6.
Co-Authors Abdurrazaq Abdurrazaq Abdurrazaq Abdurrazaq, Abdurrazaq Ahmad Ahmad Ridha Akbar, Depy Oktavian Alista, Siti Ari Surya Pratama Aristha Novyra Putri Astuti, Karunita Ika Ayunda, Feradella Azmi Yunarti Azwarina Nuke Bella Rosalina Endah Bin Jamaludin, Wahyudin Chandra, M. Andi Depy Oktavian Akbar Didik Rio Pambudi Dyera Forestryana Eka Sandra Era Habibah Faradilla Iedliany Gunawan Gunawan Gusti Khairunnisa Hadirvika Tjuthiyanda Hafiz Ramadhan Hafiz Ramadhan hairunnisa nisa Helmina Wati Hidayati Rahmi Iedliany, Faradilla Jamaludin, Wahyudin Bin Karunika Ika Astuti Khairunnisa, Gusti Liana Fitriani Hasyim Liana Fitriani Hasymi M. Andi Chandra M. Fahrul Ricky NorHavid Malik Yustika Marlia Fatwa Muammaroh Muhammad Hafizudin Muhammad Hidayattullah Muhammad Nazarudin Muhammad Nazarudin, Muhammad Muhammad Nur Rahman Hendrawan Muhammad Reza Fahlevi Muhammad Saufi Murniati . Nashrul Wathan Noor Hayati, Noor Nopita Norhasanah Norhasanah Novita Sari Nur Huda Nurbidayah Nurul Hikmah Nurul Mardiati Putri Indah Sayakti Putri Kartika Sari Putri Kartika Sari Rahmayanti Fitriah Rahmi Muthia Ratna Restapaty Rina Helmina Riwanda Oktaviani Rizka D.A. Widianti Rusida, Esty Restiana Saputri, Revita Sari Wahyunita Setyo Yogi Shelin Shelin Siti Kholilah Siti Kholilah Susiani, Eka Fitri Syaid Nofal Assegaf Syamratul Qalbiyah Syifa Tia Mariati Risma Melati Vebruati Vebruati Vebruati Vebruati Wahyudin Bin Jamalludin Wahyudin Bin Jamaludin Yuni Fahriana Yusmalina Yusmalina Yusrina Conitaty Zannah, Meryatul