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All Journal Jurnal Respirasi (JR) Jurnal Ilmiah Wahana Pendidikan Narra J Jurnal Impresi Indonesia Public Health and Safety International Journal (PHASIJ) The Journal of Society Medicine (JSOCMED) Research Horizon
Bihar, Syamsul
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Journal : Jurnal Respirasi (JR)

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CYP2A6 Genetic Polymorphism and Nicotine Metabolism of Male Smokers in Indonesia Soliha, Chaliza; Soeroso, Noni Novisari; Ananda, Fannie Rizki; Zain-Hamid, Rozaimah; Bihar, Syamsul; Lim, Darren Wan-Teck
Jurnal Respirasi Vol. 10 No. 2 (2024): May 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v10-I.2.2024.93-98

Abstract

Introduction: One of the main ingredients in cigarettes is nicotine, which has a significant impact on a person's dependence on cigarettes. Nicotine can be detected in a smoker's urine as a sign that his body is processing nicotine. The important enzyme CYP2A6 is involved in nicotine metabolism. This study aimed to determine the relationship between CYP2A6 genetic polymorphisms and nicotine metabolism among male smokers in Indonesia. Methods: This study included 100 male smokers who met the inclusion criteria in a cross-sectional design using a consecutive sampling between the ages of 20 and 65 years old. Restrictions fragment length polymorphism (RFLP) of the polymerase chain reaction (PCR) was applied to examine the genetic polymorphism of CYP2A6, and nicotine metabolite levels in urine were examined by high-performance liquid chromatography (HPLC) examination. Results: This study involved one hundred smokers, and 78 tested positive for the CYP2A6 polymorphism. The CYP2A6 genetic polymorphism and nicotine metabolism were not significantly correlated (p-value > 0.05). Allele *1A and genotype 1B/1B were more common in this study population. The majority of study participants had fast metabolic rates. Conclusion: No correlation was seen between the genetic polymorphisms of CYP2A6 and nicotine metabolism in Indonesian male smokers. Consequently, it is crucial to conduct future research in diverse populations with larger samples.
Double-Lumen vs Small-Bore Pigtail Catheter for Pleural Effusion: Which is Superior? Siagian, Novi Andriani; Soeroso, Noni Novisari; Bihar, Syamsul; Ashar, Taufik
Jurnal Respirasi Vol. 11 No. 1 (2025): January 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.1.2025.39-46

Abstract

Introduction: Pleural effusion is associated with a high mortality rate. Tube thoracostomy remains the standard treatment. Despite this, double-lumen catheters, typically used for central venous access, are infrequently employed for pleural drainage. This study compared the characteristics of patients undergoing double-lumen catheter versus pigtail catheter placements for pleural effusion. Methods: A retrospective cross-sectional study was conducted on adult patients at Prof. Dr. Chairuddin Panusunan Lubis Universitas Sumatera Utara Hospital, Haji Adam Malik General Hospital, and St. Elisabeth Hospital, Medan, from September 2022 to April 2024. This study analyzed patient demographics and clinical presentations for those receiving either catheter type. Results: The mean age of patients with double-lumen catheters was 58.21 years old, while those with pigtail catheters averaged 54.9 years old. Patients with double-lumen catheters frequently presented with a combination of shortness of breath, cough, and chest pain, while those with pigtail catheters primarily reported shortness of breath. Both groups predominantly exhibited exudative pleural effusions. Radiological evaluations indicated moderate pleural effusion was most common in both groups, with thoracic ultrasound revealing fluid volumes between 500 and 2,000 cc. Conclusion: Double-lumen catheters are more frequently utilized for moderate to massive pleural effusion, whereas pigtail catheters are typically reserved for moderate cases. The choice of catheter depends on the patient's condition, the underlying cause of the effusion, and radiological findings.
Co-Authors AHMAD JAMALUDIN Ananda, Fannie Rizki Arman Lany, Arman Assilmy Lubis, Muhammad Rizky Bintang Y.M. Sinaga, Bintang Y.M. Erna Mutiara Fachrina, Intan Hafid Syahputra Harahap, Feby Yanti Jie, Elvin Shon Kardiasyah, Alzi Lim, Darren Wan-Teck Lubis, Netty D. Nadia, Agnes Noni Novisari Soeroso Pantja P, Emilia Saminoe Purba, Angela Yurika Putri, Junia Putri, Radhita Sylvia Rambe, Rivan Yudha Siagian, Novi Andriani Sihite, Marisi Ester Nova Soliha, Chaliza Syarani, Fajrinur Taufik Ashar Yoan Carolina Panggabean Yuyut, Prayuti Zain-Hamid, Rozaimah