Objective – To analyze the influence of competence and professionalism significantly on the performance of midwives at the Kendari City Regional General Hospital. To analyze the influence of competence significantly on the performance of midwives at the Kendari City Regional General Hospital. And to analyze the influence of professionalism significantly on the performance of midwives at the Kendari City Regional General Hospital. Design/Methodology/Approach – This study uses quantitative methods. The population in this study was midwives working at the Regional General Hospital (RSUD) of Kendari City. Respondents taken in this study amounted to 41 people with information from midwives who were in the Raung Ponek Azalea. The data collection method used in this study was using questionnaires and documentation. This study used multiple linear regression analysis. Findings – Competence and professionalism together have a positive and significant influence on the performance of midwives at the Kendari City Regional General Hospital (RSUD). Implications – Competence and professionalism together have a very important role in improving the performance of midwives at the Kendari City Regional General Hospital (RSUD).