This study aims to test the truth of the hypothesis and analyze the Influence of Perception of Cognitive Style and Learning Interest on Understanding Physics Concepts. The study used a survey method. The population of the study were students in four study programs at the Health Polytechnic in South Jakarta with a sample size of 88 people. The sampling technique used random sampling. The study used a questionnaire on perception of cognitive style, a questionnaire on learning interest and a test of understanding physics concepts. The data analysis used multiple linear regression. The conclusions obtained from the hypothesis testing are: 1) There is a significant influence of perception of cognitive style and learning interest together on students' understanding of physics concepts. This is evidenced by the sig value of 0.000 <0.05 and Fcount = 26.084. 2) There is a significant influence of perception of cognitive style on students' understanding of physics concepts. This is evidenced by the sig value of 0.047 <0.05 and tcount = 2.013. 3) There is a significant influence of learning interest on students' understanding of physics concepts. This is proven by the acquisition of sig value 0.001 < 0.05 and tcount = 3.426.