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All Journal Alchemy : Journal of Chemistry Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Program Kreativitas Mahasiswa - Penelitian JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA JURNAL ENGGANO Logista: Jurnal Ilmiah Pengabdian Kepada Masyarakat Jurnal Ilmiah Farmasi Farmasyifa Jurnal Kefarmasian AKFARINDO Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Bioscientist : Jurnal Ilmiah Biologi Pharmaceutical And Biomedical Sciences Journal (PBSJ) Jurnal Pharmacopoeia Jurnal Pengabdian Masyarakat Bangsa JAMAS: Jurnal Abdi Masyarakat Journal of Community Empowerment BATOBO: Jurnal Pengabdian Kepada Masyarakat Bencoolen Journal of Pharmacy Jurnal Pengabdian Kepada Masyarakat Bersinergi Inovatif Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Reza Pertiwi
Program Studi S1 Farmasi, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Bengkulu, Bengkulu
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Journal : Pharmaciana: Jurnal Kefarmasian

 1 
The effect of Raphanus sativus and Pachyrhizus erosus juice combination on the ethanol-induced gastric of mice Reza Pertiwi; Aanisah Hanuun; Noval Kurniawati; Petri Siti Khodijah; Dian Fita Lestari; Dyah Fitriani; Doni Notriawan
Pharmaciana Vol 11, No 3 (2021): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (530.078 KB) | DOI: 10.12928/pharmaciana.v11i3.20104

Abstract

Gastric ulcers can be caused by active inflammation due to impaired mucosal integrity, which causes local or widespread lesions. Gastric ulcers can occur due to the use of ethanol, which has a local effect on the gastric. Therefore, the continuous consumption of ethanol can damage gastric cells. Raphanus sativus and Pachyrhizus erosus contain flavonoids, which are well-known to reduce stomach acid as a curative agent.  The objective of this study is to see the effect of Raphanus sativus and Pachyrhizus erosus juice as a preventive agent on alcohol-induced gastric ulcers in mice (Mus musculus). A combination of Raphanus sativus and Pachyrhizus erosus was given at a dose of 100, 300, and 600 mg/kgBW. Specifically, Raphanus sativus was given at a dose of 300 mg/kgBW, Pachyrhizus erosus at a dose of 300 mg/kgBW, and positive control was included using sucralfate. The treatment was carried out for 12 days, and 1 hour after the last day of treatment, 20 ml/kgBW of ethanol induction was given 24 hours after the animals were dissected. The results showed that the index value of gastric ulcers in the normal group, negative control, and the combination of Raphanus sativus and Pachyrhizus erosus juice given orally at a dose of 100, 300, and 600 mg/kgBW (Raphanus sativus at a dose of 300 mg/kgBW, Pachyrhizus erosus at a dose of 300 mg/kgBW, and sucralfate as positive control) were 0; 4.00; 1.00; 1.33; 2.33; 2.67; 0 and 2.00. The results of the histopathological analysis also showed improvement in the gastric of mice fed with Pachyrhizus erosus juice. Therefore, it is inferred that treatment using Raphanus sativus and Pachyrhizus erosus juice can reduce the number of ulcers, increase ratio protection, and repair the cells in gastric histopathology. Additionally, giving a single dose of Pachyrhizus erosus juice results in a more significant gastric improvement. 
Co-Authors Aanisah Hanuun Agung Giri Samudra Agus Martono Agustianto, Sandy Alawiya Simanullang, Khairatul Alfarizi, Aziz Aniza, Mifta Violina Asdim Az Zahra, Farah Azhar, Afra Wafiqah Bekti Widiansyah, Alif Desi Novita Reviana, Desi Novita Dhea Ananda Dian Fita Lestari Dian Handayani Dian Handayani Dominica, Dwi Dyah Fitriani Eni Kurniati, Eni Ernis, Gustria Fadhila, Muhammad Adeng Fadila Jeni Salsabila Fadila, Muhammad Adeng Feby R.A Putri Fitri Ramadhanti Hanuun, Aanisah Hari Marta Saputra Hari Marta Saputra Harianti Putri, Yona Hendri Saputra Hizkia Puspa Pertiwi Ikhsan Ikhsan Ilfanisari, Vinolla Indah Sari, Puput Tri Iwan Mahmud, Iwan Kamilla Putri, Dwi Khaliq, Iyas Nur Khodijah, Petri Siti Komala Sari, Delia Kurnia, Ridho Kurniawati, Noval Lestari, Dian Fita Lestari, Mustika Dewi Mutyarini, Afiska Nasution, Riski Padilah Nesbah, Nesbah Nofa Risma Azis, Nofa Risma Notriawan, Doni Noval Kurniawati Nurjali, Zavira Oky Hermansyah Petri Siti Khodijah Prameswari, Florencaya Prameswari Prima Yudha, Sal Putri Nurlita, Septia Putri, Fadilla Aliyah Putri, Khoirunnisa Awaliyah Putri, Yona Harianti Radestian, Juwita Triananda Rahmawati, Reza Ramadhani, Nasywa Fathia Reni Susanti Riana Versita Risky Hadi Wibowo Rochmah Supriati SALPRIMA YUDHA S Salsabila, Adinda Okta Sani K, Fathnur Santi Nurul Kamilah Sari, Rose Intan Perma SEPTI WULANDARI Sihombing, Imelda Simatupang, Muhaida Ramzany Sipriyadi Syahidah, Aminah Syalfinaf Manaf Triawan, Deni Agus Tya Chalifatul Welly Darwis Wibowo, Aprillia Devi Wibowo, Risky Wibowo, Risky Hadi Yona Harianti Putri