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All Journal Jurnal Dunia Farmasi Best Journal (Biology Education, Sains and Technology) Jurnal Aisyah : Jurnal Ilmu Kesehatan JUKESHUM: Jurnal Pengabdian Masyarakat Journal of Pharmaceutical and Sciences. Jurnal Sains dan Kesehatan
Rambe, Robiatun
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Journal : Jurnal Aisyah : Jurnal Ilmu Kesehatan

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DETERMINATION OF METRONIDAZOLE MICROPARTICLE CONTENTS IN THE HEMISELLULOSE MATRIX OF CORN COB USING ULTRAVIOLET SPECTROPHOTOMETRY Dalimunthe, Gabena Indrayani; Rani, Zulmai; Rambe, Robiatun
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 9, No 2 (2024): September
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v9i2.2607

Abstract

Microparticles can be an accurate drug delivery agent, reducing drug concentration in the target and providing an effective delivery system for substances that are slightly soluble in water. Corn cobs contain the most hemicellulose, and this hemicellulose can be employed as a matrix to restrict medication release if administered orally. The purpose of this study is to use UV spectrophotometry to evaluate the concentration of metronidazole microparticles in the hemicellulose matrix of corn cobs. This research is divided into two stages: separating hemicellulose from corn cobs and characterization of hemicellulose, which includes visual organoleptics, taste, smell, and form. Solubility test in alkaline conditions (NaOH), followed by FTIR test using the KBr pellet method with typical peaks seen in the FTIR spectrum, SEM test to get structural morphology, and PSA test to determine particle size and distribution of representative samples. After the microparticles are formed, further characterization is carried out, including an organoleptic test, solubility test, PSA test, FTIR test, and SEM test. Next, the levels of metronidazole microparticles in the corncob hemicellulose matrix were determined using ultraviolet spectrophotometry by comparing metronidazole tablets on the market. The concentration of metronidazole microparticle sample in the corncob hemicellulose matrix was determined to be 80.12 0.5290%, and the concentration of metronidazole tablets on the market was 100.51 0.7576%, which meets the requirements for metronidazole tablet concentration, namely not less than 90.0% and not more than 110% of the amount stated on the label.
Co-Authors Affan Silalahi, Ali Aini Khairunnisa, Nur Athaillah, Athaillah Chandra, Putra Elanda, Yurike Gabena Indrayani Dalimunthe Ginting, Ovalina Sylvia Br Ginting, Ovalina Sylvia Br. Harahap, Armansyah Maulana Harahap, Aswan Pangondian Hura, Arlitus Khairunnisa, Nur Aini Lestari, Amanda Putri Lusia Simatupang, Lenny Maulida Lubis, Roqayyah Monalisa, Anggi Muhammad Taufik Daniel Hasibuan Pangondian, Aswan Priawan, Indra Saddam Husein, Saddam Sakira, Dila salamah salamah Sartika Daulay, Anny Silalahi, Ali Affan Sugito - Virnoldi, Ukti Yahya Gulo, Trifani Yetty Machrina Ziza Putri Aisyia Fauzi Zulmai Rani