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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Medical Journal of Indonesia Journal of General Procedural Dermatology and Venereology Indonesia JOURNAL LA MEDIHEALTICO eJournal Kedokteran Indonesia Media Dermato-Venereologica Indonesiana Journal of General-Procedural Dermatology & Venereology Indonesia Bali Dermatology Venereology and Aesthetic Journal Jurnal MedScientiae Jurnal Kedokteran Meditek
Lili Legiawati
Department Of Dermatology & Venereology, Faculty Of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Hospital, Jakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Journal : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Centella asiatica : alternative dry skin therapy in type 2 diabetes mellitus Lili Legiawati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 53, No 3 (2021)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (19.061 KB) | DOI: 10.19106/JMedSci005303202108

Abstract

Diabetes mellitus (DM) in Indonesia has rapidly increased during recent years. World Health Organization (WHO) predicted that in 2030, Indonesia would be ranked fourth for the largest DM patients in the world. As the disease progresses, uncontrolled type 2 DM (T2DM) results in dry skin as the most prevalent skin disorder. Despite the prevalence and morbidities that lead to infection, ulcer, gangrene that can lead to amputation when insufficiently treated, dry skin in T2DM has limited therapeutic options. Currently, available therapies for dry skin in T2DM have not considered factors of hyperglycemia and hyperinsulinemia, which disturb skin homeostasis. Nonetheless, in T2DM, there are neuropathy and biostructural changes of the skin which induce dry skin. Alternative herbal medicine, Centella asiatica is getting well-known nowadays because of its vast amount of benefits. Centella asiatica has been studied for its antioxidant, antidiabetic, anti-inflammation, antiglycation, and neuroprotective activities. Furtherly, these properties may display benefits when introduced to T2DM dry skin therapy. The previous clinical study had shown that topical C. asiatica improved dry skin. This clinical study was also supported by in vitro studies. Currently, pharmacological profile studies of C. asiatica including dosage, toxicity, and safety have been available. This article aimed to review the current literature on the potential of C. asiatica as an alternative to treat dry skin in T2DM.
Co-Authors Adistri, Kara Andhira, Vega Astriningrum, Rinadewi Barros, Terlinda Batubara, Irwan Bianti, Marsha Chairista, Inadia Putri Chandrakesuma, Vivianne Endi Novianto Evita H. Effendi Fauziah, Siti Nurani Fifi Mifta Huda Gunardi, Keiko Yolanda Halim, Dionisius Ivan Yonathan Hartanto, David Dwiadiputra Hoemardani, Aida SD Huda, Fifi Mifta Imelda Wihadi Indah Widyasari Irawan, Yudo Jonlean, Reganedgary Keumala Budianti, Windy Krisanti, Roro Inge Ade Krisanti, RR Inge Ade Kusmarinah Bramono Kusumawardhani, Dina Larisa Paramitha Marizki Ramadhani, Reinanda Marsha Bianti Melody Febriana Andardewi Miranda, Eliza Muhammad, Parikesit Nadia Yusharyahya, Shannaz Nadia, Department of Dermatology and Venereology, Faculty of Medicine Universitas Indonesia – Dr. Cipto Mangunkusumo National Central General Hospital Jakarta, Indonesia Shannaz, Yusharyahya Nugraheni Pasaribu, Uly Aanda Maria Pandjaitan-Sirait, Sondang MHA Priyanto, Mufqi Handaru Rahadi Rihatmadja Rahadi Rihatmadja Reshinta, Reisa Rheza, Agung Mohamad Rinadewi Astriningrum Rosdiana, Dewi Selvina Sampurna, Adhimukti T Sandra Widaty Shannaz Nadia Yusharyahya Sirait, Sondang P. Siskawati, Yulia Siti Nurani Fauziah Sitohang, Irma Bernadette Sitohang, Irma Bernadette Simbolon Sondang P Sirait Sri Adi Sularsito Sri Adi Sularsito Sri Adi Sularsito Sri L. Menaldi Sujudi, Yufanti Suseno, Lis Surachmiati Terlinda Barros Vivianne Chandrakesuma Wahyudi, Danang T Wardani, Amanda Nandi Widyasari, Indah Wihadi, Imelda Windy Keumala Budianti Wresti Indriatmi B. Makes Yudo Irawan Yudo Irawan