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All Journal Jurnal Ilmu Kefarmasian Indonesia Sainstech Farma: Jurnal Ilmu Kefarmasian Jurnal Farmasi Indonesia
Maria, Nisa
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Journal : Jurnal Farmasi Indonesia

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Penyesuaian Dosis dan Potensi Interaksi Antibiotik pada Pasien Infeksi Saluran Kemih dengan Penyakit Ginjal Kronis Maria, Nisa; Arrum Kusumawardani, Larasati; Rinaldi, Dinar Syifa Ulya; Wilda Risni, Hindun
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 16 No. 1 (2024): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v16i1.222

Abstract

Infeksi Saluran Kemih (ISK) merupakan suatu penyakit infeksi yang dapat memperburuk kondisi pasien dengan penyakit komorbid seperti Penyakit Ginjal Kronis (PGK). Pasien ISK dengan PGK yang dirawat inap umumnya mendapatkan terapi antibiotik. Namun, penggunaannya berpotensi menimbulkan Masalah Terkait Obat (MTO) karena adanya risiko nefrotoksisitas pada beberapa antibiotik, gangguan terhadap farmakokinetik obat, dan banyaknya peresepan obat pada pasien PGK. Studi cross-sectional ini bertujuan untuk mengevaluasi kesesuaian dosis dan potensi interaksi obat pada pasien ISK dengan PGK rawat inap pada salah satu RSUD di DKI Jakarta. Sejumlah 78 sampel penelitian diperoleh menggunakan teknik total sampling. Data sekunder pasien meliputi resep, rekam medis, dan hasil laboratorium pasien periode tahun 2018-2022 diambil secara retrospektif. Analisis MTO menunjukkan bahwa 13 pasien (17,1%) menerima dosis antibiotik tidak sesuai dan 34 pasien (43,6%) mengalami potensi interaksi obat. Uji statistik menggunakan Chi-square menunjukkan bahwa ketidaksesuaian dosis antibiotik lebih sering ditemukan pada kelompok PGK stage 4-5 (p= 0,041; OR=4,744) dan lama rawat inap >6 hari (p= 0,032; OR= 5,067) serta kejadian potensi interaksi obat antibiotik lebih banyak dialami oleh pasien berjenis kelamin perempuan (p= 0,007; OR= 4,667), PGK stage 4-5 (p= 0,024; OR=3,208), jumlah riwayat komorbid selain PGK >2 (p= 0,046; OR= 2,827), dan jumlah obat >10 (p= 0,031; OR= 3,061). RSUD tersebut sudah menerapkan praktik pemberian antibiotik pasien ISK-PGK dengan baik namun dapat ditingkatkan lagi dengan melakukan pemantauan obat dan pasien secara ketat, terutama terkait penyesuaian dosis dan potensi interaksi obat antibiotik.
Pengembangan Instrumen Penilaian Tingkat Pengetahuan, Sikap, Dan Perilaku Swamedikasi Batuk Versi Bahasa Indonesia Maria, Nisa; Apriani, Elvina; Sari, Kartika Citra Dewi Permata
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 17 No. 1 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i1.220

Abstract

Cough is a symptom that people often treat with self-medication. Self-medication practice can be formed from knowledge and attitudes. The development of this instrument aimed to obtain a valid and reliable Indonesian language questionnaire to measure the level and relationship of knowledge, attitudes, and cough self-medication practice in adult patients. The questionnaire was prepared based on literature studies and developed by the Dagusibu concept and cough management. Three pharmacists from academia and the community became validators in the face and content validation test. Construct validation and reliability tests were obtained from 30 adult respondents who had carried out cough self-medication in Jabodetabek. Content validation was carried out in 2 stages. The results of the first stage test had an S-CVI score of 0.93, with 26 questions having an I-CVI value <0.79, so stage 2 validation was carried out, which met the I-CVI and S-CVI scores. The total number of questions from content validation was 143, divided into 6 parts. The final questionnaire had 137 questions consisting of sections A-B (8 questions) for personal and sociodemographic data; part C (30 questions) related to self-medication profile; part D (36 questions) about knowledge with a 3-point Guttman scale; part E (30 questions) related to attitudes with a 5-point Likert scale; and part F (33 questions) about behavior with a 2-point Guttman scale. The final questionnaire met the criteria of validity and reliability and could be filled in independently by respondents in Indonesia.
Co-Authors Apriani, Elvina Fauziyyah, Afina Nur Kusumawardani, Larasati Arrum Nadia Farhanah Syafhan Nurma Yunita, Nurma Permata Sari, Kartika Citra Dewi Rinaldi, Dinar Syifa Ulya Risni, Hindun Wilda Sari, Kartika Citra Dewi Permata Simarmata, Mayannaria Susilo, Ferlina Vidyananda Sutantoputri, Dini Badriyanti Wilda Risni, Hindun