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All Journal Jurnal Ilmiah Farmasi EKSAKTA: Journal of Sciences and Data Analysis Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) CHEESA: Chemical Engineering Research Articles JSFK (Jurnal Sains Farmasi & Klinis) Medfarm: Jurnal Farmasi dan Kesehatan Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Farmasi Sains dan Praktis Indonesian Journal of Pharmacology and Therapy
Arba Pramundita Ramadani
Jurusan Farmasi Universitas Islam Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Journal : Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan

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AKTIVITAS ANTIBAKTERI DAN ANTIBIOFILM DARI EKSTRAK DAUN BANGUN-BANGUN (Coleus amboinicus L.) TERHADAP BAKTERI Staphylococcus aureus Fitra, Romadhonsyah; Romadhonsyah, Fitra; Aisha Nanda Caela Amry; Annisa Fitria; Arde Toga Nugraha; Arba Pramundita Ramadani; Nangim Khasanah
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 2 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i2.2173

Abstract

Biofilm formation by bacteria, especially the genus Staphylococcus, is a serious health problem. Various medicinal plants have been used to control the infection, but research related to the antibiofilm activity of Coleus amboinicus is still limited. Bangun-bangun leaves (C. amboinicus) are plants from the Lamiaceae family that contain secondary metabolites such as terpenoids, flavonoids, and phenolics that are thought to be responsible as antibacterial and antibiofilm. This study aims to examine the antibacterial and antibiofilm activity of C. amboinicus against S. aureus. C. amboinicus leaves were extracted using 96% ethanol. The ethanol extract was then screened for phytochemicals using Thin Layer Chromatography (TLC) using several spray reagents. Antibacterial activity was analyzed using microdilution technique to obtain the value of Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC). Antibiofilm activity was analyzed using crystal violet method. The result showed that the ethanol extract of C. amboinicus leaves contained flavonoids, phenolic terpenoids, and tannins. Antibacterial assays were obtained for the MIC value of 8 mg/mL and MBC of 16 mg/mL. The ethanol extract showed biofilm inhibitory activity with an IC50 value of 2,40 mg/mL. Based on these results, C. amboinicus has potential antibacterial and antibiofilm activity to inhibit S. aureus.
Co-Authors Aisha Nanda Caela Amry Annisa Fitria Annisa Fitria Annisa Fitria Arde Toga Nugraha Ari Marstiyani Arismunandar, Arif Baruna, Renno Ramadhani Ika Cynthia Astiti Putri Diesty Anita Nugraheni Fanny Rahma Maulida Fitra, Romadhonsyah Fuadah, Shofiatul Hakim, Sherina Nabila Putri Hayati, Farida Jasno Jasno Kamarulzaman, Ezatul Ezleen Larysa Fernenda Lutfi Chabib, Lutfi Maria Hilaria Maulidha Amanati Muhammad Sulaiman Zubair Mustafidah, Mabrurotul Nangim Khasanah Poluan, Jesica Carine Priska Ernestina Tenda Rochmy Istikharah Romadhonsyah, Fitra Sherina Nabila Putri Hakim Suryani, Arman Syafira Tri Nurmala Sari Tamhid, Hady Anshory Tika Luthfi Sadrina Trianloka, A. M. Bagas Yandi Syukri