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All Journal Medica Hospitalia Berita Kedokteran Masyarakat
Dewi, Julita Melisa
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Journal : Medica Hospitalia

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Hubungan Tympanogram dengan Lokasi dan Ukuran Tumor pada Pasien Karsinoma Nasofaring Dewi, Julita Melisa; Marliyawati, Dwi; Muyassaraoh, Muyassaroh
Medica Hospitalia : Journal of Clinical Medicine Vol. 9 No. 1 (2022): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (257.771 KB) | DOI: 10.36408/mhjcm.v9i1.682

Abstract

Introduction : Hearing loss is the most frequent symptomps of patients with Nasopharyngeal Carcinoma (NPC), because there is a connection between the middle ear and the nasopharynx through the eustachian tube. Tympanometry is a hearing test in terms of evaluating the middle ear. Objective : This study aimed to evaluate the correlation between the tympanogram and the location and size of the nasopharyngeal carcinoma tumor at Dr. Kariadi General Hospital Semarang. Methods : This is a descriptive analytic study with cross-sectional study design of NPC patients at Dr. Kariadi Hospital Semarang, July 2020 to June 2021. Tympanometry was performed at the beginning of the diagnosis of NPC, the location and size of the tumor based on a head and neck physical examination, nasopharyngoscopy and CT scan results. Data analysis with spearmen rho . test. Result : From 52 subjects were diagnosed with NPC, most of them were in the 5th decade. The most common location of the tumor was in Rossenmuler fossa and extended to the wall and roof of the nasopharynx bilaterally (n=29; 55,7%). The most tumor size was T4 (n=26;50%). The results of statistical analysis showed that the tympanogram image had a strong correlation with the location of the tumor in NPC patients (r=0.853; p<0.001), but had no correlation with tumor size (r=0.061; p=0.668). Conclusion : The tympanogram in NPC is related to the location of the tumor, not to the size of the tumor.
The Effect of Coenzym Q10 on Doxorubicin-induced Cardiotoxicity in Non Hodgkin's Lymphoma Patients Dewi, Julita Melisa; Antono, Dwi; Nugroho, Nur Iman; Yusmawan, Willy; Dewi, Anna Mailasari Kusuma
Medica Hospitalia : Journal of Clinical Medicine Vol. 11 No. 2 (2024): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v11i2.1089

Abstract

BACKGROUND : Non-Hodgkin's Lymphoma is a primary malignancy in the Lymph Nodes and lymphoid tissue originating from B lymphocytes, T lymphocytes and Natural Killer (NK) cells. Therapy for Non-Hodgkin's Lymphoma chemotherapy can be given alone or combined with radioactive therapy. Doxorubicin is a chemotherapy drug used for lymphoma with side effects, one of which is cardiotoxic effects. AIMS :  To prove that coenzyme Q10 can reduce the cardiotoxic effect of doxorubicin chemotherapy in non-Hodgkin's lymphoma patients METHOD : Intervention study with a randomized pre and post test double blind control group design with 34 NHL patients undergoing chemotherapy. The treatment group received additional therapy with coenzyme Q10 300mg/day for 12 weeks while the controls received placebo. The cardiotoxic effects examined were assessed based on the results of Electrocardiography and Echocardiography. RESULT :  The treatment group with coenzyme Q10 supplementation after the 4th chemotherapy showed a decrease in echocardiography results in 3 patients (18%) and in the control group 17 patients (100%). There was a significant difference in the echocardiography results of the treatment and control groups (p=0.001). There were no drug side effects in both groups CONCLUSION : Coenzyme Q10 supplementation provides an improvement in the cardiotoxic effects of doxorubicin in non-Hodgkin's lymphoma patients, on echocardiography, but not on Electrocardiography.
Co-Authors Antono, Dwi Dewi, Anna Mailasari Kusuma Marliyawati, Dwi Muyassaraoh, Muyassaroh MUYASSAROH Nugroho, Nur Iman Willy Yusmawan, Willy