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All Journal Jurnal Ilmu-Ilmu Perairan dan Perikanan Indonesia Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Prosiding Seminar Biologi Jurnal Kedokteran Brawijaya Majalah Kedokteran Bandung The Journal of Experimental Life Sciences (JELS) Medical Journal of Indonesia Jurnal Pembangunan dan Alam Lestari Proceeding International Conference on Global Resource Conservation AGRIVITA, Journal of Agricultural Science Jurnal Pendidikan Biologi Indonesia Universa Medicina Jurnal Penelitian Pendidikan IPA (JPPIPA) Biosaintifika: Journal of Biology & Biology Education Journal of Research in Instructional Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek) Jurnal Kedokteran Hewan Indonesian Journal of Jamu
Sutiman B. Sumitro
Brawijaya University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Physics Public Health Veterinary Other

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Journal : Jurnal Kedokteran Brawijaya

 1 
INTERVENSI CYTOADHERENCE SEBAGAI PELUANG UNTUK PENCEGAHAN DAN TERAPI MALARIA BERAT Simamora, Dorta; Sumitro, Sutiman B.; Fitri, Loeki Enggar
Jurnal Kedokteran Brawijaya Vol 22, No 2 (2006)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (269.666 KB) | DOI: 10.21776/ub.jkb.2006.022.02.3

Abstract

Abstract  In  malarial  infection,  erythrocytes  infected  wih  Plasmodium  falciparum  bind  to  endothelial  vascular  (endothelial cytoadherence). This binding is implicated in the forming of sequestre and  rosette that affects the vascular circulation, and thus injures  the capillary wall. This mechanism is important in pathogenesis of malarial due to dysfunction of several organs. There are several receptors of  cytoadherence in human e.g Thrombospondine (TSP), CD-36, ICAM-1, and ELAM-1 as well as specific ligands of the parasite  e.g  Plasmodium falciparum Erythrocyte Membrane Protein-1 (PfEMP-1), 220 kDa protein of Pf60, Pf332, sequestrin, Pfaldhesin and STEVOR.  PfEMP-1 has been revealed as a molecule that is responsible for pathogenesis of severe malaria. This protein can pass parasitophorous vacoular membrane (PVM) of the parasite by attaching its molecule to carry Protein Export Elemen (PEXEL) and than go to the surface of erythrocytes in combination with specific helper protein in maeurer cleft.  The intervention on cytoadherence process through blocking of specific ligand directly or blocking the translocation of this ligand to the surface of erythrocytes might be important in regulating the outcome of malarial infection.  Key words : Cytoadherence, severe malaria, intervention, adhesion molecule.
Polimorfisme Gen CYP1A1 (3801 T/C dan Ile462Val) pada Pasien Kanker Serviks Paramita, Swandari; Soewarto, Soetomo; Aris, Mohammad; Bambang, Sutiman
Jurnal Kedokteran Brawijaya Vol 26, No 1 (2010)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (603.783 KB) | DOI: 10.21776/ub.jkb.2010.026.01.5

Abstract

ABSTRAKKanker serviks menempati peringkat pertama kanker di Indonesia dengan faktor risiko merokok, paritas tinggi dan penggunaan kontrasepsi hormonal. Sitokrom P450 1A1 (CYP1A1) memegang peran dalam metabolism karsinogen pada kanker servik yaitu Benzo[a]pyrene dan estrogen. Tujuan penelitian ini adalah untuk mengidentifikasi frekuensi dan distribusi polimosfisme gen CYP1A1 (3801 T/C and LLe462Val) pada kanker servik. Polimorfirme gen CYP1A1 dianalisis dengan menggunakan metode PCR-RFLP. Pada polimorfisme gen CYP1A1 (3801TC) ditemukan 36.1% dengan tipe wild-types T/T, 37.9% heterozigot T/C dan 25.9% homozigot C/C. Pada polimorfisme gen CYP1A1 (Ile 462Val) didapatkan 56.9% tipe wild-types Ile/Ile, 37.9% heterozigot Ile/Val dan 5.2% homozigot Val/Val. Gambaran polimorfisme tersebut sama dengan penelitian lain di Asia.Kata Kunci:  CYP1A1 gene polymorphisms, kanker servik
Co-Authors a, Aulanni'am A, Aulanniam A.A. Ketut Agung Cahyawan W Agus Hadian Rahim Ahmad Taufiq Amiruddin A Amiruddin Amiruddin Anis Artiyani Aristyani, Sherry Arman Sayuti Arman Sayuti Asri Pudjirahaju Atok Miftachul Hudha Aulanni'am, Aulanni'am Basuki B. Purnomo Basuki B. Purnomo Bayyinatul Muchtaromah Chomsa Dintasari Umi Baszary Dina Maulina Djoa, Dominikus Djago Djoko W. Soeatmadji Djoko, Dionysius Joseph Dody Novrial, Dody Dorta Simamora Dwinna Aliza Dwinna Aliza Edi Widjajanto Erdiansyah Rahmi Erdiansyah Rahmi Fatchiyah Fatah Fatchur Rohman Gatot Ciptadi Hutasoit, Hostalige Ibrohim Ibrohim Ignatius Riwanto, Ignatius Iwan Iwan Iwan Lalu A. Zaenuri Lestari, Sri Rarayu Listijani Suhargo, Listijani Loeki Enggar Fitri M. Aris A. Widodo M. Aris Widodo M. Aris Widodo M. Irsyad Nur Moch Sasmito Djati Mohamad Amin Mohammad Aris Mohammad Hidayat Muhammad Aris Widodo Muhammad Hambal Muhammad Hambal Mulyadi Adam Mulyadi Adam, Mulyadi Muslim Akmal Muslim Akmal Nashi Widodo Nur Hidayat Nurul Jadid Mubarokati Radita Intan Aisyah Pratiwi Rustidja , Sembiring, Rinawati SIMON BAMBANG WIDJANARKO Soetomo Soewarto Sri Rahayu Lestari Sri Wahjuningsih Sri Wahyuningsih Sri Widyarti Suhartojo Hardjopranjoto, Suhartojo Swandari Paramita Syafruddin s Syafruddin S T. Armansyah T. Armansyah Tongku Nizwan Siregar Warsito Warsito Zairin Noor