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All Journal International Journal of Public Health Science (IJPHS) Proceedings of KNASTIK Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Science and Technology Indonesia Communications in Science and Technology Jurnal Kebidanan JFL : Jurnal Farmasi Lampung KESMAS UWIGAMA: Jurnal Kesehatan Masyarakat Indonesia Berdaya Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Sehat Indonesia (JUSINDO) Jurnal Sains dan Kesehatan
Arif Budi Setianto
Universitas Ahmad Dahlan
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : International Journal of Public Health Science (IJPHS)

 1 
Black cumin seed oil preparation consumption potentially improves adaptive cellular immune response among healthy volunteers Titiek Hidayati; Akrom Akrom; Arif Budi Setianto
International Journal of Public Health Science (IJPHS) Vol 11, No 2: June 2022
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v11i2.21425

Abstract

Oxidative stress and inflammatory reactions are the pathological mechanisms for most degenerative diseases. The black cumin seed oil (BCSO) contains compounds that can act as antioxidants and immunomodulators. Consuming BCSO is thought to improve antioxidant and immunomodulatory parameters in obese people. This study investigated the effect of BCSO consumption on antioxidant and immunomodulatory activity in healthy volunteers. We conducted a quasi-experimental study on 12 healthy volunteers in Yogyakarta, Indonesia. We asked the volunteers to consume BCSO for twenty days. We measured blood pressure, body mass index (BMI), malondialdehyde (MDA) level, Serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvate transaminase (SGPT) activity, CD4Th, and IFN-γ expression before and after consuming BCSO. We carried out the average difference test of the parameters before and after consumption of BCSO by dependent t-test. The results showed that 3x1 BCSO preparation for 20 days reduced MDA levels and increased CDTh and IFN-γ. Consuming BCSO for 20 days potentially improve the adaptive cellular immune response parameters.
Herbal supplementation improves clinical outcomes among diabetes mellitus patients Akrom Akrom; Titiek Hidayati; Arif Budi Setianto
International Journal of Public Health Science (IJPHS) Vol 12, No 2: June 2023
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v12i2.22534

Abstract

Hyperglycemic conditions are still common in diabetes melllitus (DM) patients with routine therapy. Rural communities in the Special Region of Yogyakarta habitually consume herbal medicines. Herbal nutritional supplements (MHM) were developed as additional therapy to increase the success of achieving therapeutic targets for DM patients. This study aimed to identify the clinical picture of DM patients who were given MHM at public health center (PHC) in the rural areas of Bantul Regency, Yogyakarta Special Region. This retrospective study was conducted on 94 DM patients with routine therapy. Patients who met the inclusion and exclusion criteria and had agreed to the informed consent were divided into two groups. Patients in the treatment group were asked to consume herbal supplement preparations (MHM) for 20 days. On day 21, each group measured clinical outcome parameters (blood pressure, blood glucose levels, triglycerides, cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), liver enzymes, urea, and creatinine). The mean difference test between the two groups (t-test) was carried out using a 95% confidence level. The results showed that the consumption of MHM herbal nutritional supplements for 20 days reduced blood sugar levels, Hb A1C levels, and urea levels (p<0.05). There were no differences in blood pressure, pulse, cholesterol, triglyceride, HDL, LDL, serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), and creatinine levels between the two groups (p>0.05). Administration of MHM for 20 days increased clinical outcomes in blood sugar, HbA1c, and urea levels in DM patients at PHC.
Co-Authors Abdul Fadlil Akrom, Akrom Ari Wahyudi Astuti, Febriana Capritasari, Rafiastiana Faikah Dyah Utami Hasan, Nuradnin Hasna, Elly Rosita Husain, Dewi Putri Iis Wahyuningsih Kintoko Lasanudin, Rindi Ibrahim Ma'ruf, Muhammad Mohamad Reski Manno Muhammad Yusron Maulana El-Yunusi Mustofa Mustofa Nuradnin Hasan Putri Purnamasari Putri, Meilisa Sapto Yuliani Sri Mulyaningsih Sri Mulyaningsih Titiek Suhardi Haripurnomo Kushadiwijaya Hidayati Yunda Maymanah Rahmadewi