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All Journal Abdimas Umtas : Jurnal Pengabdian kepada Masyarakat Jurnal FARMAKU (Farmasi Muhammadiyah Kuningan) Majalah Farmasetika HERBAPHARMA : Journal of Herb Farmacological Jurnal Sains Kesehatan Jurnal Pengabdian Pada Masyarakat Jurnal Komunitas Farmasi Nasional Jurnal Medika Farmaka Science and Technology: Jurnal Pengabdian Masyarakat Medical Sains : Jurnal Ilmiah Kefarmasian
Herliningsih, Herliningsih
Prodi D-3 Farmasi STIKes Muhammadiyah Kuningan
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Journal : Medical Sains : Jurnal Ilmiah Kefarmasian

 1 
FORMULATION AND PHYSICAL EVALUATION OF EFFERVESCENT GRANULES OF MINT LEAF EXTRACT (Mentha x piperita L) AS STIMULANSIA Herliningsih; Angga Anugra Diputra; Haty Latifah; Melinda Fuji Rahayu
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.922

Abstract

Indonesia is a country with a diverse biodiversity spread across various regions. Several types of plants in Indonesia can be utilised as herbal medicines. One such plant suitable for medicinal purposes is mint leaves (Mentha x piperita L.). The chemical content found in mint leaves includes essential oils that serve as stimulants. This research aims to determine whether mint leaf extract can be used to create an effervescent granule formulation. Effervescent granules are produced using the wet granulation method, incorporating the active ingredient of mint leaf extract with different concentrations: F0: without the addition of mint leaf extract; F1: mint leaf extract added with a concentration of 15%; and F2: mint leaf extract added with a concentration of 17%. The effervescent granule formula is then evaluated based on its physical characteristics. Phytochemical screening of mint leaves yielded positive results, indicating the presence of essential oils. All mint leaf extract formulations tested for physical evaluation met the specified criteria. Flow properties and angle of repose testing resulted in values between 2-3 seconds for flow properties and 35°-36° for the angle of repose. Compressibility testing produced results ranging from 5% to 15%, pH testing yielded results between 5 and 6, and dissolution time results ranged from 40 to 41 seconds.  Keywords: Mint leaves, extraction, wet granulation, effervescent granules
COMPARISON OF TOTAL FLAVONOID CONTENT AND ANTIOXIDANT ACTIVITY OF PURPLE LEAF EXTRACT (Graptophyllum pictum (L.) Griff.) USING MACERATION AND SOXHLETATION EXTRACTION METHODS Darotulmutmainnah, Azmi; Marini, Marini; Herliningsih, Herlingsih; Handayani, Hana
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1608

Abstract

Purple leaves in Indonesia can be used as an anti-inflammatory medication and laxative to treat hemorrhoids, rheumatism, boils, and skin diseases. Purple leaves are also used as free-radical antidotes. This was due to the presence of secondary metabolite compounds in purple leaves. The right extraction method determines the amount of flavonoids that can be extracted and achieves a high flavonoid content. This study aimed to determine the total flavonoid content and antioxidant activity of purple leaves using different extraction methods, namely maceration and Soxhletation. This study employed an experimental method of testing total flavonoid levels using UV-Vis spectrophotometry and antioxidant activity using the DPPH method. The results showed that the maceration method yielded a total flavonoid level of 4,422 ± 0,047 ppm, which was higher than that obtained using the Soxhletation method (1,547 ± 0,027 ppm). In the antioxidant activity test, vitamin C was used as a comparator, with an IC50 of 2.263 ppm (very strong). The IC50 of purple leaf extract using the maceration method was 123,32 ppm (medium), while the soxhletation method yielded an IC50 of 104,42 ppm (medium). This shows that vitamin C has more potent antioxidant activity in counteracting free radicals than purple leaf extract, using maceration and Soxhletation methods. The  results showed a significant difference in total flavonoid levels using different extraction methods, while there was no significant difference in the antioxidant activity of purple leaf extract using maceration and  Soxhletation methods.   Keywords: antioxidant, extraction, flavonoid, maceration, purple leaf, soxhletation  
COMPARISON OF TOTAL FLAVONOID CONTENT AND ANTIOXIDANT ACTIVITY OF PURPLE LEAF EXTRACT (Graptophyllum pictum (L.) Griff.) USING MACERATION AND SOXHLETATION EXTRACTION METHODS Darotulmutmainnah, Azmi; Marini, Marini; Herliningsih, Herlingsih; Handayani, Hana
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1608

Abstract

Purple leaves in Indonesia can be used as an anti-inflammatory medication and laxative to treat hemorrhoids, rheumatism, boils, and skin diseases. Purple leaves are also used as free-radical antidotes. This was due to the presence of secondary metabolite compounds in purple leaves. The right extraction method determines the amount of flavonoids that can be extracted and achieves a high flavonoid content. This study aimed to determine the total flavonoid content and antioxidant activity of purple leaves using different extraction methods, namely maceration and Soxhletation. This study employed an experimental method of testing total flavonoid levels using UV-Vis spectrophotometry and antioxidant activity using the DPPH method. The results showed that the maceration method yielded a total flavonoid level of 4,422 ± 0,047 ppm, which was higher than that obtained using the Soxhletation method (1,547 ± 0,027 ppm). In the antioxidant activity test, vitamin C was used as a comparator, with an IC50 of 2.263 ppm (very strong). The IC50 of purple leaf extract using the maceration method was 123,32 ppm (medium), while the soxhletation method yielded an IC50 of 104,42 ppm (medium). This shows that vitamin C has more potent antioxidant activity in counteracting free radicals than purple leaf extract, using maceration and Soxhletation methods. The  results showed a significant difference in total flavonoid levels using different extraction methods, while there was no significant difference in the antioxidant activity of purple leaf extract using maceration and  Soxhletation methods.   Keywords: antioxidant, extraction, flavonoid, maceration, purple leaf, soxhletation  
Co-Authors Angga Anugra Diputra Asep Ilham Atik Kusmiati Azmi Darotulmutmainnah Azmi Darotulmutmainnah Berliani, Fadiyah Romadhona Darotulmutmainnah, Azmi Desi Nurcahyati Duwani, Rela Erfiansyah Erfiansyah Falya, Yuniarti Fauziah, Dini Nurul Gina Maryatus Sholihah Hana Handayani Hanifah, Rakhmawati Hapsari, Dinda Alifia Haty Latifah Hopipah, Popi Lela Sulastri, Lela Linda Alfiani Maesaroh, Imas Marini Marini . Marini Marini Mas'ud, Ibnu Melinda Fuji Rahayu Menyko, Adhe Munira, Nura Amanda Nourma Nurjanah Nova Oktavia Novia Anggraini Noviani, Lusy Novitasari, Pricillia Nur Azizah Priatni, Haty Latifah Putri, Maisya Mauliana Insani Alifa Riyanti, Lisa Rizqulloh, Aditya Safira, Anita Setiadi, Encu Asep Sholihah, Gina Maryatus Suharyani, Ine sukmawati Sukmawati Sukmawati Sulis Dianengsih Wahyuni, Popi Sri Wawang Anwarudin Wiryani, Ani Siti yayang Dian Agustiana