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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Microbiology Indonesia Journal of Biomedicine and Translational Research Bioma : Jurnal Biologi Indonesia Global Health Management Journal Acta Biochimica Indonesiana Majalah Kedokteran Andalas Medika Kartika : Jurnal Kedokteran dan Kesehatan Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Tunas Medika Jurnal Kedokteran & Kesehatan JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Beti Ernawati Dewi
Departemen Mikrobiologi Fakultas Kedokteran Universitas Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Journal : JKKI : Jurnal Kedokteran dan Kesehatan Indonesia

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Immunopathogenesis of dengue virus and Salmonella typhi coinfection Nugraheni, Enny; Sudiro, Tjahjani Mirawati; Nainggolan, Leonard; Fithriyah; Dewi, Beti Ernawati
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 2, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss2.art12

Abstract

Typhoid, malaria, leptospirosis, dengue virus (DENV), and other arboviruses are endemic in Indonesia. Therefore, it is more likely that DENV and other infectious diseases could be coinfected. More severe symptoms, delayed identification, and ineffective treatment of the illness can all result from Salmonella typhi coinfection. To serve as a principle for clinicians’ considerations while diagnosing and prescribing, we aim to examine the immunopathogenesis of dengue associated with Salmonella typhi coinfection. Dengue virus has the potential to increase both susceptibility and incidence of this coinfection, leading to dengue haemorrhagic fever (DHF) with more severe clinical symptoms. This is explained by regulating impact of coinfection in the presence of gram-negative membrane endotoxin, DENV replication, and lipopolysaccharide (LPS). If Salmonella typhi coinfection is not treated promptly, both dengue and Salmonella typhi can affect several organs and result in significant morbidity and death. Dengue and typhoid immunopathogenesis coinfection are unclear. When dengue monoinfection compared with Salmonella dengue dual infections are related to higher fatality and morbidity rates.
Indonesian medicinal plants' therapeutic potential against dengue virus infection: A literature review Kartika, Aisya Alma Asmiranti; Dewi, Beti Ernawati; Sudiro, Tjahjani Mirawati
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 3, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss3.art11

Abstract

Infections caused by the dengue virus (DENV) exhibit a wide range of clinical manifestations, from asymptomatic cases to severe, and sometimes life-threatening, conditions. Therefore, identifying effective antivirals and anti-inflammatory agents is a promising strategy to reduce the impact of these infections. Indonesia, with its rich biodiversity, particularly in medicinal plants, offers potential sources for such treatments. Most research on DENV antivirals in Indonesia has been conducted in vitro and has predominantly focused on DENV serotype 2 (DENV-2). However, in vivo research on medicinal plants, as well as studies on their anti-inflammatory properties, remains limited in Indonesia.Extracts that have been investigated in both in vivo and in vitro settings are limited to Cassia alata and Curcuma longa. Plants possessing antiviral properties originate from diverse botanical families, with leaves being the most utilized plant component. Flavonoids are found in most medicinal plants that have antiviral properties. Indonesia is known to have other natural compounds, including quercetin, isobutyl gallate, curcumin, and 6-gingerol, which have antiviral properties. Curcumin and 6-gingerol are the only natural compounds that have been subjected to testing against all four serotypes of dengue. This article provides a comprehensive review of medicinal plants in Indonesia, focusing specifically on their therapeutic potential against the dengue virus.
Co-Authors . Andriansjah Agus Syahrurachman Agustin Iskandar Aldo Ferly Andi Yasmon Apriyanto, Dadan Ramadhan Aryati Aryati Budiman Bela Chie Aoki-Utsubo Cita Christine Mayorita DEKA LARASATI Desti, Hidayati Dewi Wulandari Dewijanti, Indah Dwiatmi Eleanor Louana Urfa Elisabeth D. Harahap EVA DAMAYANTI Fera Ibrahim Fithriyah Fitriyah Sjahta Hak Hotta Hardi Darmawan Heni Pujiastuti Herdiman T. Pohan Kartika, Aisya Alma Asmiranti Leonard Nainggolan Lia Meilawati Linlin Haeni Marissa Angelina Mirawati Sudiro Nadia Tita Indriasti Nikki Aldi Massardi Nugraheni, Enny Oktania Sandra Puspita OKTIVIA CHANDRA MUSTIKA PAISAL PAISAL Pramita G. Dwipoerwantoro Putra, Eduardus Gilang Rahajuningsih Dharma Rama Samara Brajawikalpa Rayasari, Husnaya Rianto Setiabudy Rizka Andhitia Mentari Putri Santi, Mei Ria Settrin Chenderawasi SJATHA, FITHRIYAH Soemanadi Sri Hartati Sri Hartati Suhendro Suhendro T. Mirawati Sudiro Tjahjani Mirawati Sudiro TJAHJANI MIRAWATI SUDIRO Tjahjani Mirawati Sudiro VIVI SETIAWATY Yulianti, Selsa YULIANTY MUHAYAR Zanjabila, Sabighoh