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Wiwin Winarsih
Department Veterinary Clinic Reproduction And Pathology, Faculty Of Veterinary Medicine, IPB University, Bogor 16680, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Nursing Public Health Veterinary Other

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Journal : Jurnal Gizi dan Pangan

 1 
Effects of Kersen leaves extract (Muntingia calabura L.) on SGOT and SGPT levels of soft drink induced mice Siddiq, Muhammad Nuzul Azhim Ash; Marliyati, Sri Anna; Riyadi, Hadi; Winarsih, Wiwin
Jurnal Gizi dan Pangan Vol. 14 No. 2 (2019)
Publisher : The Food and Nutrition Society of Indonesia in collaboration with the Department of Community Nutrition, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (297.858 KB) | DOI: 10.25182/jgp.2019.14.2.69-76

Abstract

This study aimed to analyse the antioxidant activity, total phenols, and flavonoids of kersen leaves (Muntingia calabura L.) extract (KLE) and determine the hepatoprotective activity of KLE in soft drink induced mice. Soft drinks induction causes liver injuries which increases the serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) levels. Mice were divided into five treatment groups (n=5) and were given Tween 80 (1%) (normal control), Tween 80 (1%) and 7 ml soft drinks (negative control), KLE (1000, 1500, and 2000 mg/kg), and 7 ml soft drinks per oral once daily for 4 weeks. Antioxidant activity was measured by 2.2-diphenyl-1-picrylhydrazyl (DPPH) method. Total phenols and flavonoids were analyzed by Folin-ciocalteu colorimetric and aluminium chloride (AlCl3) method. The blood samples were collected for biochemical analysis. The result showed that the KLE antioxidant activity were 11.11+0.50 ppm. Total phenols and flavonoids detected in the KLE samples were 2.19+0.12 mgGAE/g and 2.43+0.24 mgQE/g respectively. Mice treated with KLE had a significantly lower (p<0.05) serum SGOT and SGPT levels than negative control group. In conclusion, KLE has a potential hepatoprotective activity that works in synergy with its antioxidant activity.
Co-Authors A.A. Ketut Agung Cahyawan W Agus Setiyono Anita Esfandiari ARIES VERONICA Azhim Ash Siddiq, Muhammad Nuzul Bayu Febram Bibi Ahmad Chahyanto BIBIANA W LAY Chaidir Masyhuri Majiding Chitra, Febri Denny Rusmana Dwi Astuti Dwi Yanti Dyah Iswantini Efidiyana Efidiyana Eko Prasetyo Nugroho Ekowati Handharyani Fahrul Rozi Fahrul Rozi Fitri Apriani Noor Fitri Handayani Hadi Riyadi Hermonoadi Huminto I Putu Kompiang IETJE WIENTARSIH Ikrawati, Waode Intan Mayasaroh Istichomah Istichomah Istichomah Istichomah, Istichomah Istifharany Wahyudina Khairita, Lia Lia Khairita Lina Noviyanti Sutardi Majiding, Chaidir Masyhuri Maradon, Gusma Gama Miyati Sofariah Muhammad Furqon Muhammad Nuzul Azhim Ash Siddiq Nivea Nivea Nova P. Sulistyawati Nurhayu, Nurhayu Poppy Fitriyani Rachmat Wiradimadja Restu Librani Rimbawan , Rita Mutia Sang Ayu Made Adyani Setyo Retno Wulandari Siddiq, Muhammad Nuzul Azhim Ash Sri Anna Marliyati Sugyo Hastowo Sumiati Sumiati Sumiati Sumiati Sus Derthi Widhyari Umi Cahyaningsih Upik Kesumawati Hadi Wasmen Manalu Widarti Widarti Widya Hermana Yekti Widadi, Sri Yeni Alfiana Yeni Alfiana, Yeni Yulia Yellita