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All Journal Medical Journal of Indonesia The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Unggul Budihusodo
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Medicine & Pharmacology

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Study of Transaminases in Heroin Addicts Rino A Gani; Agus Sudiro Waspodo; Unggul Budihusodo; Irsan Hasan; Muhammad Sjaifoellah Noer
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 2, NUMBER 1, April 2001
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2120011-4

Abstract

A recent increase in the number of drug users particularly of heroin has been noted in the community. A cross-sectional study on the level of transaminases as a representation of liver damage in drug users was done in privated hospital in Jakarta. Exclusion criteria were fever, serious illness or the multiple use of addictive drugs based on a urinary test. The hepatitis B surface antigen (HBsAg) was examined using reverse passive hemaglutination assay (RPHA) and the antibody of hepatitis C virus core-protein (anti- HCV) with dipstick anti-HCV.  AST and ALT levels were determined using an automatic chemical analyzer. Of 132 patients who fulfill the criteria, 83.5 % were injection drug users (IDU). Means AST and ALT were significantly higher in IDU. Anti-HCV positive patients with increased AST and ALT were significantly higher compared to anti-HCV negative. The increase of transaminase was also consistent in injection drug users although no viral marker could be detected. In conclusion, the examination of transaminases in drug users especially IDU is important besides tests for hepatitis viral markers because there is often an increase with or without viral infection and this can be associated with hepatocellular damage.     Key words: Transaminase, heroin addicts, hepatitis
Co-Authors Abdul Aziz Rani Abdul Aziz Rani ACHMAD FAUZI Achmad Fauzi Agus Sudiro Waspodo Agus Waspodo Ali Sulaiman Bambang Sutopo Daldiyono Daldiyono Daldiyono Daldiyono Evy Yunihastuti Femmy Nurul Akbar Femmy Nurul Akbar H. M.S. Noer H.M. Sjaifoellah Noer Ihsanil Husna Inge A. Kristanti Irsan Hasan Julius R Samban L A Lesmana L. A. Lesmana Laurentius A. Lesmana Marcellus Simadibrata Marcellus Simadibrata Martha Iskandar Martono Roni Muhammad Sjaifoellah Noer Nanang Sukmana Nanang Sukmana Nurul Akbar Nurul Akbar Pradana Suwondo Rianto Setiabudy Rino A Gani Rino A Gani Rino A. Gani Rino Alvani Gani Rino Alvani Gani Rolan Sitompul Sjaifoellah Noer Suhardjono Suhardjono Suhardjono Suhardjono Wirasmi Marwoto Wirasmi Marwoto Zubairi Djoerban Zubairi Djoerban