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All Journal CALYPTRA : Jurnal Ilmiah Mahasiswa Universitas Surabaya JSFK (Jurnal Sains Farmasi & Klinis)
Nani Parfati
Fakultas Farmasi Universitas Surabaya
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Journal : CALYPTRA : Jurnal Ilmiah Mahasiswa Universitas Surabaya

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PENGARUH KONSENTRASI SODIUM STARCH GLYCOLATE SEBAGAI SUPERDISINTEGRAN (0% DAN 20%) TERHADAP KARAKTERISTIK FISIK ORALLY DISINTEGRATING TABLET ATENOLOL Jessica Wangsa Putri; Nani Parfati; Karina Citra Rani
CALYPTRA Vol. 7 No. 2 (2019): Calyptra : Jurnal Ilmiah Mahasiswa Universitas Surabaya (Maret)
Publisher : Perpustakaan Universitas Surabaya

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Abstract - Some geriatric patients have difficulty in swallowing tablets, resulting non-compliance issues on patient. Respond from the issues, people developed an oral dosage tablet which easily become soft and rapidly disintegrate in mouth which called orally disintegrating tablet (ODT). Atenolol is one of the anti-hypertension drugs. Atenolol is classified as antagonist selective β1 receptor class that gives the effect of anti-hypertension with low bioavailability, it is necessary to change atenolol dosage forms become ODT to increased absorption of the drug in the body. To accelerate the disintegration time (less than 3 minutes) is used disintegrant sodium starch glycolate with concentration of 0% and 20%. The method that used in the tablet’s manufacture is a direct compresssion. The result of the ODT evaluation, tablet dispersion time in vitro, wetting time , water absorption ratio, and dissolution test with its parameters include (AUC, ED and kr) were analysed statistically using one way ANOVA. There a significant difference (α = 0,05) between the formulas that using sodium starch glycolate 0% and 20% in terms of tablet’s dispersion time in vitro, wetting time, water absorption ratio, dissolution test with its parameters include (AUC, ED and kr). The formula that gives the best result is the one that using 20% disintegran sodium starch glycolate because disintegration time in 19,85±0,95 seconds, tablet’s dispersion time in vitro 29,00±1,00 seconds, wetting time 23,33±1,53 seconds, water absorption ratio 555±28,45%, TQ% 1,41 minutes, the Q% 90,64±0,44%, AUC 10134,52±29,49% minutes, ED 84,45±0,27%, and kr 0,0056/minutes.
FORMULASI DISPERSI PADAT DENGAN PERBANDINGAN KOMPOSISI PARASETAMOL DAN PEG 4000 (1:0,5DAN1:1)MENGGUNAKAN METODE PELEBURAN Jhon Leonaritua Manullang; Nani Parfati; Karina Citra Rani
CALYPTRA Vol. 7 No. 2 (2019): Calyptra : Jurnal Ilmiah Mahasiswa Universitas Surabaya (Maret)
Publisher : Perpustakaan Universitas Surabaya

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Abstract

Abstract - Paracetamol is one of drugs which has low solubility property in aqueous medium. This property will affect its bioavailability. Enhancement of solubility can be achieved by formulation of solid dispersion. Paracetamol is dispersed in PEG 4000 as hydrophilic carrier with melting method. To find the effect of the amount of PEG 4000 for the solubility enhancement, two formulas of solid dispersion are made with the ratio of 1:0.5 and 1:1. After the solid dispersion formed, this formula is characterized using FTIR to determine the interactions between paracetamol and PEG 4000 as a sign of formed solid dispersion. After characterization, the amount of paracetamol in the formulationwill be measured. Lastly, dissolution test is performed to find the increase in dissolution rate compared to pure paracetamol powder. Dissolution test profile observation shows that paracetamol and PEG 4000 solid dispersion formulas have lower dissolution rate compared to pure paracetamol. Beside that, the drug content test shows that the content of paracetamol in the dosage form doesn’t meet the quality requirement as established in the Indonesian Pharmacopeia.
Co-Authors Deviati Muarofah Jessica Wangsa Putri Jhon Leonaritua Manullang Karina Citra Rani Sovia Navacatus Sacharia