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All Journal Microbiology Indonesia Jurnal Berkala Epidemiologi Berkala Ilmu Kesehatan Kulit dan Kelamin Folia Medica Indonesiana Indonesian Journal of Tropical and Infectious Disease Indonesian Journal of Biotechnology JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA The Indonesian Biomedical Journal Jurnal Penelitian Kesehatan Suara Forikes Health Notions ISM (Intisari Sains Medis) : Jurnal Kedokteran Jurnal Abdi Insani Indonesian Journal of Anesthesiology and Reanimation (IJAR) Indian Journal of Forensic Medicine & Toxicology eJournal Kedokteran Indonesia Prosiding International Conference on Sustainable Innovation (ICoSI)
Cita Rosita Sigit Prakoeswa
Departemen Kesehatan Kulit Dan Kelamin, Fakultas Kedokteran, Universitas Airlangga, Surabaya; Departemen Ilmu Kesehatan Kulit Dan Kelamin, RSUD Dr. Soetomo, Surabaya
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Journal : Microbiology Indonesia

 1 
Profile of Mutation on Drug Resistance Mycobacterium leprae Isolates in Indonesia Collected During 2003-2011 RATNA WAHYUNI; DINAR ADRIATY; ISWAHYUDI ISWAHYUDI; CITA ROSITA SIGIT PRAKOESWA; INDROPO AGUSNI; SHINZO IZUMI
Microbiology Indonesia Vol. 6 No. 3 (2012): September 2012
Publisher : Indonesian Society for microbiology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (338.244 KB) | DOI: 10.5454/mi.6.3.7

Abstract

Multidrug therapy (MDT) regiment has been used for leprosy all over the world for more than 20 years. Drug resistances of Mycobacterium have been reported from many areas. The resistance mostly occurred due to mutation on the gene coding protein targeted by anti-leprosy drugs. Two hundreds and seventy M. leprae isolates from some area in Indonesia were examined for studying the profile of mutation among isolates collected during 2003-2011. Drug resistance determining region of the folP1 gene and the rpoB gene was sequenced. The results showed 5 isolates of M. leprae harboured mutation only in the folP1 gene and another isolate harbored mutation in both the folP1 and rpoB gene. The point mutation in the folP1 gene that was found in 2 isolates occurred in codon 53 (ACC→GCC; Thr→Ala). Double point mutations on codon 53 that was found in two isolates were ACC→AGA (Thr→Arg) and ACC→AGG (Thr→Arg). The point mutation in the folP1 geneoccurred in codon 55 were found in two isolates were CCC→CTC (Pro→Leu) and CCC→CGC (Pro→Arg). Whereas mutation in the rpoB gene in one isolate occurred in codon 410 was GAT→TAT (Asp→Tyr). These mutations that altered the amino acids of the protein revealed that isolates of M. leprae were resistant to drug with variable profiles
Co-Authors Abdul Karim Abdullah, Salsabilla Putri Kinanti Afif Nurul Hidayati Afif Nurul Hidayati, Afif Nurul Agatha Anindhita Ardhaninggar Agatha Anindhita Ayu Ardhaninggar Agnes Sri Siswati Agung, Jeffrey Agus Aan Adriansyah Agus Sri Wardoyo Alpha Fardah Athiyyah Amak M. Yaqub Anang Endaryanto Anang Endaryanto Anggraen, Sylvia Anggraeni Noviandini Anggraeni Noviandini, Anggraeni Anggraeni, Sylvia Anna Surgean Veterini Antoni Miftah Antoni Miftah, Antoni Anum, Qaira Arifin Saiboo, Alvian Arlina Dewi Astindari Astindari Astindari, Astindari Ayu Umborowati, Menul Bagus Bagus Bagus Haryo Kusumaputra Bagus Haryo Kusumaputra Bagus Haryo Kusumaputra, Bagus Haryo Bella Ayu Paramitha Bintanjoyo, Lunardi Budi Prasetyo Budi Utomo Budi Utomo Budiono Budiono Chesia Christiani Liuwan Christina Avanti Cindy Fransisca, Cindy Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Tinduh Deasy Fetarayani Devi, Aprilin Krista Dewi Nurasrifah Dewi Puspitorini Dhelya Widasmara Dhyah Aksarani Handamari Diah Mira Indramaya Diana Kartika Sari Diana Kartika Sari, Diana Kartika DINAR ADRIATY Dominicus Husada Dwi Murtiastutik Dwikora Novembri Utomo Dyah Ayu Pitasari DYAH FAUZIAH, DYAH Dyah Ratri Anggarini Dyah Ratri Anggarini, Dyah Ratri Eighty Mardiyan K, Eighty Eliza, Frizka Endang Wahyu Fitriani Erwin Astha Triyono Esti Hendradi Eva Lydiawati Evy Ervianti Evy Ervianty, Evy Fajrin, Farah Meriana Farah Adiba, Asmahan Farahannisaa, Kintan Adelia Farhat Surya Ningrat Febrina D Pratiwi Febrina Dewi Pratiwi Fedik Abdul Rantam Ferdiansyah Ferdiansyah Mahyudin Ferriastuti, Widiana Fifa Argentina Flora Ramona Sigit Prakoeswa Gatot Soegiarto Geani, Silvani Gede Wirya Kusuma Duarsa Hamidah, Berliana Hamzah Hardyanto Soebono Hari Basuki Notobroto Hari Sukanto, Hari Hartanto, Felix Hasna, Iffa Halimah Heri Suroto I Gusti Ayu Agung Elis Indira I Gusti Ayu Agung Praharsini I Gusti Nyoman Darmaputra Indah Purnamasari Indah Purnamasari INDROPO AGUSNI INGRID SURYANTI SURONO Ingrid Suryanti Suryono Intan Primasari Irma Tarida Listiyawati Irma Tarida Listiyawati, Irma Tarida Irmadita Citrashanty Irmadita Citrashanty Irmadita Citrashanty, Irmadita Iskandar Zulkarnain Iskandar Zulkarnain Isnaniyanti Fajrin Arifin Iswahyudi Iswahyudi Iswahyudi Izzatul Fithriyah Jastika, Faradistiani Rakhmawati Jayawarsa, A.A. Ketut Kartika Paramita Komaratih, Evelyn Kurniati Kurniati KUSUMASTUTI, ETTY HARY laissa Bonita Laksmi Wulandari Laura Navika Yamani Linda Astari, Linda Lubis, Ramona Sari Luh Made Mas Rusyati Lutvia Hidayati M. Yulianto Listiawan Made Putri Hendaria Mamuaja, Enricco Hendra Mappamasing, Hasnikmah Marissa Astari Rubianti Marsudi Hutomo Marsudi Hutomo Maya Weka Santi Maylita Sari Maylita Sari, Maylita Medhi Denisa Alinda, Medhi Denisa Medisika, Dhea Meita Ardini Pratamasari, Meita Ardini Menul Ayu Umborowati Menul Ayu Umborowati Menul Ayu Umborowati Menul Ayu Umborowati Menul Ayu Umborowati, Menul Ayu Muchtar, Vitayani Mulianto, Nur Rachmat Nadia Wirantari Nadia Wirantari, Nadia Nadya Divina Baihaqi Ni Made Inten Lestari Nisa Qurrota Ayun Novianti Rizky Reza Nugroho, Wisnu Triadi Nur Hidayah Nyoman Suryawati Oki Wihardiyanto Pakpahan, Cennikon Pepy D. Endraswari Pepy Dwi Endraswari, Pepy Dwi Pradiptha, I Nyoman Tri Prajitno, Subur Prameswari, Faida Ufaira Pratiwi, Karina Dyahtantri Puput Ade Wahyuningtyas Puteri, Rr. Astrid Aulia Artiono Rahmadewi Rahmadewi Rahmadewi Ratna Wahyuni RATNA WAHYUNI Regitta Indira Regitta Indira Agusni Renata Prameswari Renni Yuniati Retha Retha Ria Hanistya Ridha Ramadina Widiatma Ridha Ramadina Widiatma Rina Mutya Suzliana Riyana Noor Oktaviyanti Riyana Noor Oktaviyanti Romaniyanto Romaniyanto Romaniyanto Rubianti, Marissa Astari S.Pd. M Kes I Ketut Sudiana . Santi Martini Santoso, Kohar Hari Santoso Hari Sari, Desiana Widityaning Sari, Vida Cahlia Novita Sawitri Sawitri Sawitri Sawitri Sawitri Sawitri Sawitri Semedi, Bambang Pujo SHINZO IZUMI Silvani Geani Sri Awalia Febriana Sri L. Menaldi Subijanto Marto Soedarmo Sugianto, Ronald Sunarso Suyoso Tanojo, Natalia Tengku Riza Zarzani N Thinni Nurul Rochmah Tjokorda Gde Bagus Mahadewa Tri Wibawa Trias Mahmudiono Trisniartami Setyaningrum Tristiana Erawati Troef Soemarno Troef Soemarno, Troef Widji Soeratri Willy Sandhika Wisnu Triadi Nugroho Wisnu Triadi Nugroho Wisnu Triadi Nugroho Yetti Hernaningsih Yohanes Aditya Adhi Satria Yuindartanto, Andre Yuri Widya Yusuf Wibisono Yuyun Rindiastuti