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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences JURNAL GIZI INDONESIA Jurnal Manajemen Bisnis Fokus Bisnis BISNIS: Jurnal Bisnis dan Manajemen Islam Proceeding Seminar LPPM UMP Tahun 2014 INDONESIAN JOURNAL OF PHARMACY DERIVATIF Jurnal Akuntansi dan Pajak As-syifaa Jurnal Farmasi ANNALES BOGORIENSES RJABM (Research Journal of Accounting and Business Management) Muhammadiyah International Journal of Economics and Business SENTRALISASI International Journal of Islamic Business and Economics (IJIBEC) Jurnal Ilmiah Akuntansi dan Keuangan Jurnal Ilmu Manajemen Jurnal Mantik BALANCE Jurnal Akuntansi dan Bisnis International Journal of Economics, Business and Accounting Research (IJEBAR) Jurnal Ilmiah Edunomika (JIE) Budimas : Jurnal Pengabdian Masyarakat Entrepreneurship Bisnis Manajemen Akuntansi (E-BISMA) Jurnal Ekonomi dan Bisnis Digital (MINISTAL) East Asian Journal of Multidisciplinary Research (EAJMR) Makara Journal of Science Asian Journal of Management Analytics Prosiding University Research Colloquium International Journal of Business and Applied Economics (IJBAE) e-Jurnal Apresiasi Ekonomi IIJSE Fokus Bisnis: Media Pengkajian Manajemen dan Akuntansi Riset Akuntansi dan Keuangan Indonesia International Journal of Economics, Business and Innovation Research JIPITI: Jurnal Pengabdian kepada Masyarakat JURNAL MANAJEMEN DAN BISNIS INDONESIA Annales Bogorienses
Akhmad Darmawan
Department of Chemistry University of Indonesia Kampus Depok, Jl. Margonda Raya, Depok, West Java, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Social Sciences Other

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Journal : Annales Bogorienses

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Cytotoxic Activity of Flavonoid Compounds Isolated from Tetrameles Nudliflora Leaves Megawati, Megawati; Darmawan, Akhmad; Fajriah, Sofa
Annales Bogorienses Vol. 23 No. 2 (2019): Annales Bogorienses
Publisher : BRIN

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Abstract

Tetrameles nudliflora is one of the endemic plants in Wallace region, especially in Mekongga Forest, Southeast Sulawesi, Indonesia. As part of our project in the field of natural drug discovery based on local bioresources, this study aimed to isolate secondary metabolite compounds from the ethyl acetate fractions of the leaves of T. nudiflora and evaluate their cytotoxic activities against breast carcinoma cancer lines, MCF-7. The methods used were various chromatography techniques such as vacuum column chromatography, gravitation column chromatography, thin layer chromatography, preparative thin layer chromatography, and re-crystallization using two different organic solvents. In the present study, two flavonoid compounds, kaempferol (1) and quercetin (2) were identified. The structures of 1-2 were determined using serial spectroscopic techniques, including mass spectrometry, one- and two-dimensional nuclear magnetic resonance. Moreover, using 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyl tetrazolium bromide (MTT) assay method, both compounds showed in vitro cytotoxic activity IC50 of 34.162 and 133.148 μg mL-1, respectively against MCF-7 cell lines.
Identification of a New Compound as α-Glucosidase Inhibitor from Aspergillus aculeatus Dewi, Rizna Triana; Suparman, Asep; Mulyani, Hanny; Darmawan, Akhmad; Lotulung, Puspa Dewi N.
Annales Bogorienses Vol. 20 No. 1 (2016): Annales Bogorienses
Publisher : BRIN

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Abstract

Terestrial fungi are of great importance as potential sources of pharmaceutical agent. Aspergillus aculeatus, a fungus isolated from soil sample collected in Indonesia, was cultured in liquid media to investigate a novel compound as inhibitor -glucosidase. The mycelium extract of A. aculeatus shows potential activity against Saccharomyces cereviseae -glucosidase and mild activity against mammalian -glucosidase with IC50 values of 9.57 μg/mL and 470.76 mg/mL, respectively. Enzyme assay-guided fractionation of this extract afforded rubrofusarin (1). Rubrofusarin, a linear naphtho--pyrone, is a natural pigment from Aspergillus sp. Interestingly, compound 1 shows potential inhibitory activity against mammalian -glucosidase (IC50 of 92.7 μg/mL), but no to S. cereviseae -glucosidase. The results suggest that A. aculeatus is a promising natural source as a lead compound in the discovery of antidiabetic drug.
Co-Authors ., Alfalisyado A.A. Ketut Agung Cahyawan W Ahmad Randy Ahmad Wahyudin Aisya, Sitti Amir Amir Anggelina, Yosita Anggraini, Intan Anggun Puspita Ariani, Novita Arini Hidayah, Arini Aris, Muhammad Rizqie Aryawibawa, Anja Dwi Aryoko, Yudhistira Pradhipta Aryoko, Yudistira Pradipta ASEP SUPARMAN Bagis, Fatmah Barlian, Putri Bekti Divayani, Naelin Dinda Condro Nur Alim Darmawan , Althaffauz Najwa Dewijanti, Indah Dwiatmi Endang Saepudin, Endang Erny Rachmawati Fadzilah, Rizqiya Nur Fitriani, Azmi Fitriati, Azmi Galuh Widiyarti Hani Mulyani, Hani Haryanto, Totok Hasanah , Uswatun Hengky Widhiandono Heri Syahrian, Heri Hermin Endratno Indah Rahmawati Indahsari, Ninik Dewi Irfanesa, Irfanesa Jamhari Jamhari Jaroenwanit, Pensri Kharismasyah, Alfato Yusnar Kurnia, Kesih Kusbandian, Ani Leonardus B.S. Kardono Lia Meilawati Lotulung, Puspa Dewi N. Maharani, Adinda Safirah Maharani, Annisa Dwi Maharani, Wilia Krisna Mahmudah, Diana Maulida Nurul Innayah Maulidiyah Mawaddah, Apriani Medi Hendra, Medi Megawati Megawati - Megawati, Melliana, Sinta Bella Miftahuddin, Muchammad Agung Minarti Minarti Muhammad Hanafi Muhammad Nurdin Muji R., Tri Septin Mulyani, Hanny Mulyani, Hanny Naelati Tubastuvi Nina Artanti Nisa, Ainun Nofianingsih, Elsa Nugroho, Bambang Haryo Nur Umami, Kharisma Aulia Nurfiani, Aisah Nurhanifah, Salma Pratama, Bima Cinintya Pratama, Bintang Rizki Pratiwi, Firda Ardianti Primahana, Gian Purnadi Purnadi, Purnadi Puspa Dewi Narrij Lotulung Putra, Nafis Mahesa Putragita, Yudhistira Rahmawati, Dwi Vina Rahmawati, Ika Yustina Randikaparsa, Irawan Restu Frida Utami Rimbawan, Bagas Akbar Dwi Pangestu Rizna Triana Dewi sandra dewi Satria, Agri Bayu Setiyaningrum, Anggun Siska Liana Sofa Fajriah Soleh Kosela Sri Wahyuni Sri Wahyuni SUKIRNO Sunardi Sunardi Supriadi, Edi Suwarsito Suyono Suyono Suyoto Suyoto Teni Ernawati Tri Septin Muji Rahayu, Tri Septin Tri Utami Wahyudi P. Suwarso, Wahyudi P. Wida Purwidianti Widyaningtyas, Dian Widyasmara, Meriska Yogi Widzayanto, Luthfi Arie Wiranti, Elza Devi Yasin, Roqi Yundari, Yundari Yuswandani, Arafah Esa