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All Journal International Journal of Integrated Health Sciences Althea Medical Journal Berkala Ilmu Kesehatan Kulit dan Kelamin
Jono Hadi Agusni
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Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Journal : International Journal of Integrated Health Sciences

 1 
Comparison of the Effectiveness of Phosphorus 32 Application and 10 Mg/Cc Triamcinolone Acetonide Intralesional Injection on Keloid Hani Indrayati; Jono Hadi Agusni; Asmaja Soedarwoto; Achmad Hussein S. Kartamihardja
International Journal of Integrated Health Sciences Vol 4, No 1 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Objective: To analyze the effectiveness of phosphorus 32 (32P) application compared to 10 mg/cc triamcinolone acetonide (TA) intralesional injection in keloid.Methods: A single blind (evaluator blind) randomized clinical trial on 52 keloids was conducted during the period of May – August 2014 in Tumor and Skin Surgery Clinic, Department of Dermatovenereology and Department of Nuclear Medicine and Molecular Imaging, Dr. Hasan Sadikin General Hospital Bandung.Results: Lesions were divided into two groups with each group consisted of 26 lesions. Group A was treated with 32P application whereas group B was treated with 10 mg/cc TA intralesional injection. Flattening of the lesion of more than 50% was higher in the group treated with 32P application (76.9%) compared to the group that was treated with 10 mg/cc TA intralesional injection (57.7%) on the 8th week, but the difference was not statistically significant (p>0.05).Conclusions: Based on the statistical analysis, the application of 32P was as effective as the intralesional injection of 10 mg/cc TA for keloid lesions.Keywords: Flattening, keloid, phosphorus 32, triamcinolone acetonide DOI: 10.15850/ijihs.v4n1.683
Triamcinolone Acetonide and 5-Fluorouracil Intralesional Combination Injection in Keloid Treatment Jono Hadi Agusni; Eva Krishna Sutedja; Franky Chandra
International Journal of Integrated Health Sciences Vol 5, No 1 (2017)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Objective: To evaluate the effectiveness of steroid and 5-fluorouracil (5-FU) injection combination for keloid management.Methods: A 22-year-old female patient was presented with recurrent skin lesions. The skin lesions first appeared 10 years prior to consultation, had been surgically excised, and were given triamcinolone acetonide injection. However, no improvement was observed. A decision was made to use and evaluate treatment using an intralesional 4 mg (0.1 ml of 40 mg/ml) triamcinolone acetonide and 45 mg (0.9 ml of 50 mg/ml ) 5-FU injection combination for 5 weeks.Results: Clinical improvements were observed in the third week as the lesions softened and pruritic sensation dinimished. At the end of the fifth week, improvements in the form of keloid lesion flattening and size reduction were observed.Conclusions: Intralesional injection using a combination of triamcinolone acetonide and 5-fluorouracil is effective for keloid lesion treatment.Keywords: 5-fluorouracil, intralesional injection, keloid, triamcinolone acetonide DOI: 10.15850/ijihs.v5n1.959
Co-Authors Achmad Hussein S. Kartamihardja Asmaja Soedarwoto Egie Rahmalaelani Eva Krishna Sutedja Franky Chandra Hani Indrayati Hartati Purbo Dharmadji Hermin Aminah Usman