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All Journal Jurnal Lahan Suboptimal Jurnal EduBio Tropika Biogenesis: Jurnal Ilmiah Biologi The International Journal of Tropical Veterinary and Biomedical Research Outline Journal of Community Development
Fahmy Armanda
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Environmental Science Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences Veterinary

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Journal : Biogenesis: Jurnal Ilmiah Biologi

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Neuronal cell death in the amygdala and cerebral cortex of mice (Mus musculus) induced by bee (Apis mellifera) venom Rian Oktiansyah; Ummi Hiras Habisukan; Anggun Wicaksono; Yustina Hapida; Fahmy Armanda
Biogenesis: Jurnal Ilmiah Biologi Vol 11 No 1 (2023)
Publisher : Department of Biology, Faculty of Sci and Tech, Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/bio.v11i1.36165

Abstract

Brain is an organ to control our activities, such as human consciousness, emotional, and movement. It was controlled by amygdala and cerebral cortex as the parts of the brain. Many things that can bring over it. Bee venom (BV) is known as traditional medicine and probably can sway the brain. The objective of this study was to determine the dose of BV that causes excessive neuronal cells death, especially in the amygdala and cerebral cortex. About 15 white male mice Deutsch Denken Yoken (DDY) strain were divided into control group and the treatment group. BV was administrated intraperitoneally for two weeks with multilevel doses, that was 1.88 mg/kg, 3.76 mg/kg, 5.6 mg/kg, and 7.48 mg/kg. Brain tissue isolation was performed three days of the last administration by using perfusion method. Morphological sectioned of brain tissue (amygdala and brain cortex) was stained by hematoxylin-eosin (HE). The results indicated that the BV inclined to affect neuronal cells death in the amygdala and cerebral cortex. Based on the study, the highest doses (7.48 mg/kg) of BV caused the highest neuronal cell death.
Co-Authors Abdullah Abdullah Anggun Wicaksono Fathya Nabila Jhon Riswanda M Ali S Muhammad Dekar Rian Oktiansyah Rizqi Safitri Rudi Hermansyah Salsabilla Ummi Hiras Habisukan Widyastika, Dinda Yustina Hapida