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Qurnianingsih, Ema
Department Of Biochemistry, Faculty Of Medicine, Airlangga University, Surabaya, Indonesia
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Journal : Majalah Biomorfologi (Biomorphology Journal)

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EFFECTS OF LOW DOSE EXPOSURE OF BORAX FOR 8 WEEKS ON GASTRIC ULCER FORMATION Audi Salman Faza; Linda Dewanti; Ema Qurnianingsih
Majalah Biomorfologi Vol. 30 No. 1 (2020): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (490.038 KB) | DOI: 10.20473/mbiom.v30i1.2020.7-13

Abstract

Background: Borax, a carcinogenic toxicant, is illegally used as food additives frequently. Previous researches shown that high dose of borax exposure (300 mg/kg of BW) caused gastric ulcer, but low dose of borax, as found as usual dose in food, has not been frequently researched. Objective: The aim of this study was to analyze the effects of low dose of borax for 8 weeks on the formation of gastric ulcer. Materials and Methods: Twenty four young adult rats (Rattus norvegicus) were divided into 4 groups (Control, Group 1, 2, and 3). Borax doses of 50 mg/kg, 150 mg/kg, and 300 mg/kg were administered on groups 1, 2, and 3 respectively through sonde for 8 weeks; Control group was not exposed with borax. Body weight was monitored every 2 weeks. On the last day of the experiment, rats were euthanized and gastric ulcers were histopathologically analyzed using a microscope. The data were analyzed by the comparative test of Mann-Whitney and the significancy was set on p<0.050. Results: The results showed that body weight was significantly different on the 6th week between Control vs Group 1 (p=0.010) and Control vs Group 3 (p=0.043). The grade of gastric ulcer was found higher in Group 2 and Group 3 compared to Control (p=0.019 and 0.011 respectively). Conclusion: Both of low dose (150 mg/kg BW) and high dose (300mg/kg BW) of borax exposure for 8 weeks cause microscopic gastric ulcer on rats.
Co-Authors . Kholik Alda Dini Wijayanti Amin, Indah Binti Mohd Arifa Mustika Audi Salman Faza Ayesie Natasha Zulka Bakhtiar, Arief Bayu Satria Wiratama Brahmana, Alisha Princessa Choirotussanijjah Damayanti Damayanti Damayanti Dyah Kencono Wungu, Citrawati Eka Arum Cahyaning Putri Elvaretta, Clarissa Ely Rahmatika Nugrahani Fajar Shamsudin Fajar Syamsudin Ginanjar Sasmito Adi Gosy Endra Vigriawan Hamzah, Arshq Mirza Harianto Notopuro Hendri Susilo Hera, Renata Evania HERAWATI, LILIK Hermina Novida, Hermina Humairah, Ira Humairah, Ira Ira I'tishom, Reny Indri Safitri Indri Safitri, Indri Ira Humairah Ira Humairah Jefferson Caesario Jemima Lewi Santoso Kadek Rachmawati Khaerunnisa, Siti Lilia Putri Pratama Lilik Djuari Linda Dewanti Lukitasari, Lina Mangestuti Agil Maridsky, Aldilla Afifie Putri Miranda Jemyma Mas&#039;ulun Muhammad Hidayat Palupi, Dian Eka Roro Prabowo, Gwenny Ichsan Pradana, Munawer Purwanta, Marijam Purwitasari, Neny Putri Brillian Betrista Viorizka Ramadhani, Rizqi Nabila Rejeki, Purwo Sri Retno Handajani Rias Gesang Kinanti Riwu, Katty Hendriana Priscilia Rusyda, Aqila sabila Siti Khaerunnisa Siti Khaerunnisa Soebagijo Adi SOETJIPTO . Sudibyo, Devi Ariani Suhartati Sulistiawati Sulistiawati Susi Wahyuning Asih Suwandito Suwandito Syafa’ah, Irmi Trisniartami Setyaningrum Ummah, Fithriyah Cholifatul Ummah, Fithriyah Cholifatul Ummah Vania Islamey Kusuma Waskito, Langgeng Agung Wungu, Citrawati Dyah Kencono Yuri Widia, Yuri Zachawerus, Anjeli Cristina Zuhrotul Eka Yulis Anggraeni