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All Journal CHEMISTRY PROGRESS Jurnal Farmasi Sains dan Komunitas Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Sains dan Kesehatan
Natsir Djide
Fakultas Farmasi UNHAS
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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Journal : Jurnal Farmasi Galenika (Galenika Journal of Pharmacy)

 1 
Efek Sinergitas Ekstrak Kulit Jeruk (Citrus sinensis L) Pada Patch Bioselulosa Dalam Meningkatkan Penyembuhan Luka Bakar: Synergetic Effect of Orange Peel Extract in Biocellulose Patch Toward Burn Wound Healing Roska, Tri Puspita; Sahati, Syahidah; Fitrah, Andi Dinul; Juniarti, Nana; Djide, Natsir
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 4 No. 2 (2018): (October 2018)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (128.748 KB) | DOI: 10.22487/j24428744.2018.v4.i2.10472

Abstract

Burns is one of the incidents that can lead to death (mortality). One of the natural products that have potential to serve as an alternative treatment of burns is orange peel. Orange peel has a chemical composition such as ascorbic acid, vitamin E, vitamin A, and polyphenols as antioxidants that inhibit free radicals responsible in the pathogenesis of both acute and chronic inflammatory. In this study, formulation was made in the form of biocellulose which is the primary metabolism product of bacteria. The purpose of this research was to obtain the concentration of the extract of orange peel on bioselullose that have the effect of decreasing the burn wound in rats. Orange peel was extracted then fortified into biocellulose with a concentration of 3%, 6%, and 9%. After that, the wound healing was tested on animals in the form of decreasing the wound diameter. The results showed that the concentration of extract of orange peel 3% on the fortification of biocellulose showed the good percentage of burn wound decreasing i.e. 45.52% with diameter average of 18.35 mm. This result indicates the concentration of extract of orange peel 3% is better than others.
Sinergitas Aktivitas Antibakteri dari Kelopak Bunga Rosella dan Kitosan Terhadap Staphylococcus aureus: Synergistic Antibacterial Activity of Roselle Calyx and Chitosan against Staphylococcus aureus Haeriah, Haeriah; Djide, Natsir; Alam, Gemini; Sartini, Sartini
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 4 No. 2 (2018): (October 2018)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (233.522 KB) | DOI: 10.22487/j24428744.2018.v4.i2.10590

Abstract

Currently, the antibacterial research is increasingly promoted primarily from natural materials, due to the increasing number of pathogenic bacteria that have been resistant to existing antibiotics. One of the pathogenic bacteria that has been much resistant to antibiotics is Staphylococcus aureus. Rosella calyx (Hibiscus sabdariffa L.) and chitosan are known to have antibacterial activity. The aim of this study to find out the antibacterial synergy of the roselle calyx extract and chitosan against. S.aureus ATCC 33592. Rosella calyx was extracted by maceration using 80 % ethanol, while chitosan is obtained from deasetilation chitin of shrimp husk. Test antibacterial synergism using checkboard assay method by calculating the minimum inhibitory concentration (MIC) using microdilution assay. The results showed minimum inhibitory concentration (MIC) value of roselle calyx extract and chitosan were 1250 ppm and 50 ppm, respectively. MIC value of rosella calyx extract in the presence of chitosan was 625 ppm, while the value of MIC chitosan in the presence of rosella calyx extract was < 0.19 ppm. Fractional Inhibition Concentration Index (FICI) was < 0.5 which concluded that the combination of roselle calyx extract with chitosan has a synergistic antibacterial effect on S.aureus ATCC 33592.
Co-Authors Abdullah, Surya Sumantri Arifin, Arfiani Djide, Nana Juniarti Natsir Fitrah, Andi Dinul Gemini Alam Haeriah Haeriah, Haeriah Muhtar, Mardiyana Natsir, Sartini Nurhidayah Nurhidayah Roska, Tri Puspita Sahati, Syahidah Sartini Sartini