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All Journal Farmaka Pelita Masyarakat Edu Masda Journal Edu Dharma Journal: Jurnal penelitian dan pengabdian masyarakat INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal) Jurnal Assyifa: Jurnal Ilmu Kesehatan Lhokseumawe Jurnal Medical Laboratory IJESPG (International Journal of Engineering, Economic, Social Politic and Government) journal Madani: Multidisciplinary Scientific Journal Detector: Jurnal Inovasi Riset Ilmu Kesehatan Medic Nutricia : Jurnal Ilmu Kesehatan Jurnal Kesehatan dan Kedokteran Jurnal Sains dan Kesehatan Darussalam Jurnal Medika Farmaka Pharmaceutical Science Journal Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Jurnal Pharma Bhakta Jurnal Kefarmasian Indonesia Jurnal Sains & Kesehatan Darussalam JOURNAL OF Pharmacy and Tropical Issues
Firdha Senja Maelaningsih
STIKes Widya Dharma Husada Tangerang
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : Jurnal Kefarmasian Indonesia

 1 
Formulation of Instant Granules from Ethanolic Extract of Melinjo Peel (Gnetum gnemon L) Extract as Anti-Hyperuricemia Sari, Diah Permata; Fahriati, Andriyani Rahmah; Maelaningsih, Firdha Senja
Jurnal Kefarmasian Indonesia VOLUME 13, NUMBER 2, AUGUST 2023
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v13i2.6290

Abstract

Melinjo (Gnetum gnemon L) is extensively found in Indonesia, and all of its components are highly employed, with the fruit being the most commonly used. However, melinjo fruit can induce hyperuricemia if ingested excessively since it contains purines, which can raise uric acid levels. Several investigations have found that melinjo peel can lower uric acid levels in experimental rats in vivo. As a result, the goal of this study is to create and evaluate immediate granule formulations of melinjo peel extract. Plant determination, standardization of specified parameters, standardization of non-specific parameters, formulation, and physical and chemical assessment of instant granules of melinjo peel extract are all steps of the technique. This study employed two instant granule formulations of melinjo peel extract FI and FII with varying PVP concentrations (1g FI and 3g FII). Flow time testing, angle of repose testing, compressibility index testing, water content testing, and dissolving time testing were all part of the physical examination of instant granules. The chemical evaluation took the form of a UV-Vis spectrophotometer study of total flavonoid levels in instant extracts and granules. The FI and FII instant granule formulas had a yellow color, the flow time test results were in a good category (44 g/s and 81 g/s), the angle of repose test results was in the very good flow properties category (19° and 16°), the compressibility test results, the water content test, and the dissolving time test were performed in triplo, in 0, 7th, and 14th day, and the results were in a good category. In conclusion, the physical features of instant granules of FI and FII melinjo peel extracts fulfilled the requirements for all test parameters and had a high possibility to be produced as anti hyperuricemia preparations.
The Characterization of Instant Granule Melinjo Peel (Gnetum gnemon Linn.) as Alternative Treatment for Hyperuricemia Maelaningsih, Firdha Senja; Sari, Diah Permata; Fahriati, Andriyani Rahmah; Saputra, Teungku Raviola; Ansori, Andika Al
Jurnal Kefarmasian Indonesia VOLUME 15, NUMBER 1, FEBRUARY 2025
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Hyperuricemia is a non-communicable disease characterized by high levels of purine in the blood. One of the foods high in purine is melinjo chips. Instant granules from melinjo peel extract with a concentration of 450 mg have been proven to be effective as an anti-hyperuricemia treatment. To ensure the quality of the instant granule preparation, a quality evaluation was conducted to establish it as a new alternative in hyperuricemia therapy. The study aimed to assess the quality of the instant granule preparation of melinjo peel extract, including physical evaluation (particle size, loss on drying, and pH), characterization with Scanning Electron Microscope (SEM) and Fourier Transform Infrared Spectroscopy (FT-IR), and specific microbial tests. The test results revealed that the particle size of the instant granules was classified as coarse particles, the Loss on Drying results showed 1.29% granule loss, and the pH evaluation indicated that the granules had a pH of 7.78. Based on the SEM characterization, the granules exhibited non-clumping and heterogeneous morphology. FTIR analysis showed the presence of quercetin in the instant granules of melinjo peel. Specific microbial testing indicated the absence of E. Coli in the preparation. Therefore, it is concluded that the instant granule preparation of melinjo peel has characteristics that make it suitable for development as an instant nutraceutical granule preparation for anti-hyperuricemia treatment.
Co-Authors Abdillah Abdillah Adelia Rahmawati Ahmad Sopian, Ahmad Airani, Rahma Arla Airin, Ivo Ovia Akhmad Sobarudin Aledea Safitri Aliya Nur Hasanah Amartyavica Asta Ginasih Amelia, Ditha Andina, Cantika Andriyani Rahmah Fahriati Anggel Imelda Ranboki Anis Dwi Kristiyowati Anjeli Rahmawati Ansori, Andika Al Assyifa Rachma Citra Aurli Fitria Ayu Werawati Azizah Nurma Qurotul ‘Aini Azzahra, Fathia Beny Maulana Satria Bheta Sari Dewi Cahyani, Lufitha Evelyne Chasanah, Eneng Uswatun Dara, Nabila Dea Ayu Anggraeni, Dea Ayu Anggraeni Denisa, Dila Dewi Astuti, Mardyana Dhea Mutiara Diah Permata Sari DIAH PERMATA SARI, DIAH PERMATA Dimas Agung Waskito Wijanarko Dinah Suwaybatul Aslamiyah Dinda Yuliantika Elena Prida Elza Tiani Lestari Evani, Azmi Zauli Fadiya Qotrunnada Fajrin, Aulia Farah Aulia Qatrunnada A Farhan Aziz, Muhammad Febriyanti, Nabila Fenita Purnama Sari Indah Frederico, Frederico Fu'adah, Intan Tsamrotul Gandes Winarni Getrudis Anita Seran Hapsari, Maretha Vien Helina Hermat Hermat Hersa, Mutiara Hidayatri, Nurul Humaira Fadhilah Ihsani, Salfia Ika Andini Ika Elvina Rahmawati Indiarti Ayu Silvia Ismiati, Hastin Kristiyowati, Anis Dwi Laelatun Nupus Larasati Larasati Larasati, Fannisa Dini Lestari, Bilqisti Rahmadani Lilik Febriyani Linawati Linawati Lisna Sari Luciana Luciana Mokodompit, Nurhaliza Martasya Muhamad Kholilu Navis Muhammad Ikhsanul Kahfi Muzaqil, Firmansyah Nabila N Nadia Shinta Purnomo Nanang Yunarto Nazila Khoerunnisa Novita Sary Nur Hasanah Nurhakiki, Nurhakiki Nurida Nurihardiyanti Nurihardiyanti, Nurihardiyanti Nurohmah, Alivia Octaviela, Tyara Oktaviani, Livia Ovia Airin, Ivo Pomalingo, Dwina Ramadhani Putri Nur Auliya Rahman Putri Sartika Rahma Shalsadilla Rahmalia, Rahmalia RIRIS ANDRIATI Rismiyanti, Aina Sahara, Khalipatun Sahira Madliya, Juliettania Salsabila, Fannysa Saputra, Teungku Raviola Saputri, Laras Tri Saputri, Safira Nurul Islam Sayyidah Sayyidah Sayyidah, Sayyidah Selvi Ramadani Silfiana, Ayu Sirait, Sertiwan Siti Chodijah Siti Fauziah Ahmad Suny Koswara Rahajeng SUSANTI Susanti Susanti Syuhriah Syuhriah Tiara Fitri Anggraeni Utami, Anissa UZ, LM Zulfahrin Vien Hapsari, Maretha Vina Fauziah Yollanda, Ade Yuhareza Aulia Eka Putri, Yuhareza Aulia Eka Putri Yulianingrum, Mutiara Yunita Yunita Zulfahrin, LM