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All Journal Jurnal Veteriner Folia Medica Indonesiana Nusantara Medical Science Journal Jurnal Kesehatan Reproduksi JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Sri Sulistyowati
Bagian Obsteterik Dan Ginekologi, Fakultas Kedokteran, Universitas Sebelas Maret/ RSUD Dr. Moewardi Surakarta. Jl. Kolonel Sutarto 132, Surakarta, Jawa Tengah, Indonesia.
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Journal : Folia Medica Indonesiana

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Hypoxia Inducible Factor-1-Alpha Expression on Preeclampsia Mice Model With L-Arginine Administration Nutria Widya Purna Anggraini; Sri Sulistyowati; Muhammad Adrianes Bachnas; Eric Edwin Yuliantara; Wisnu Prabowo; Uki Retno Budihastuti
Folia Medica Indonesiana Vol. 57 No. 3 (2021): September
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (430.04 KB) | DOI: 10.20473/fmi.v57i3.22733

Abstract

Preeclampsia is hypertension in pregnancy that affects 2% to 8% of pregnancies worldwide and causes significant maternal and perinatal morbidity and mortality. In the pathogenesis of preeclampsia, placental hypoxia plays an important role, associated with excessive trophoblast apoptosis resulting in decreased trophoblast and spiral arteries invasion. This placental hypoxic condition will induce increased expression of Hypoxia Inducible Factor -1-Alpha (HIF-1-A). L-Arginine is a potent vasodilator presumably to improve preeclampsia placental hypoxic conditions and reduce HIF-1-A expression. This study was an experimental study with a parallel-group post-test only design. Thirty-six preeclamptic mice models were divided into 2 groups. The control group (K1) 18 preeclamptic mice model without treatment and the treatment group (K2) 18 preeclamptic mice given L-Arginine. The independent variable was the administration of L-Arginine and the dependent variable is the placental HIF-1-A expression. Statistical analysis used unpaired t-test on normal data distribution, and Mann Whitney test on abnormal data distribution. The mean of placental HIF-1-A expression K1 was 2.47 ± 1.65 with a minimum value of 0.4 and a maximum value of 6.6. At K2 0.93 ± 0.55 with a minimum value of 0.0 and a maximum value of 2.0. Statistical tests showed that the placental HIF-1-A expression in the treatment group was significantly lower than that in the control group (p <0.001). In conclusion, the expression of HIF-1-A in preeclamptic mice model placenta decreased with L-Arginine administration.
Co-Authors Aldi Firmansyah Bambang Triono Cahyadi Dewi Setiyawati Dympna Pramelita Eric Edwin Yuliantara Erindra Budi Cahyanto Hafi Nurinasari Hari Wujoso Lungguk Helen Alfian Tanjung Metharisa Sujana Muhammad Adrianes Bachnas Nutria Widya Purna Anggraini Rubin Enhui Tjiang Soetrisno Soetrisno Soetrisno Soetrisno soetrisno soetrisno Soetrisno Soetrisno Supriyadi Hari Respati Supriyadi Hari Respati Supriyadi Hari Respati Uki Retno Budihastuti Wisnu Prabowo