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All Journal Jurnal Gizi dan Pangan Jurnal Ilmu Pertanian Indonesia Jurnal Silvikultur Tropika (JST) JURNAL KIMIA SAINS DAN APLIKASI Prosiding Seminar Biologi Biogenesis: Jurnal Ilmiah Biologi Jurnal Tanaman Industri dan Penyegar Current Biochemistry SC (Savana Cendana) : Jurnal Pertanian Konservasi Lahan Kering Indonesian Journal of Chemistry JURNAL PENGABDIAN KEPADA MASYARAKAT Menara Perkebunan Jurnal Ilmu dan Teknologi Kayu Tropis Jurnal Ilmu Kefarmasian Indonesia JTRM (Jurnal Teknologi dan Rekayasa Manufaktur) Wood Research Journal : Journal of Indonesian Wood Research Society Al-Ahwal Al-Syakhsiyyah: Jurnal Hukum Keluarga dan Peradilan Islam Wood Research Journal : Journal of Indonesian Wood Research Society Al-Muamalat : Jurnal Ekonomi Syariah Jurnal Informatika Teknologi dan Sains (Jinteks) Journal of Law, Poliitic and Humanities Innovative: Journal Of Social Science Research Jurnal Penelitian Kehutanan Wallacea Molekul: Jurnal Ilmiah Kimia La-Tahzan: Jurnal Pendidikan Islam Jurnal Medika: Medika IEMJ: Islamic Education and Management Journal
Syamsul Falah
Departemen Biokimia, Fakultas Matematika Dan IPA, IPB
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Journal : Current Biochemistry

 1   2 
Uji Fitokimia dan Identifikasi Senyawa-Senyawa Metabolit Sekunder Ekstrak Etil Asetat, Etanol dan Air Tanaman Zingiber zerumbet Asal Pulau Timor Origenes Boy Kapitan; Laksmi Ambarsari; Syamsul Falah
Current Biochemistry Vol. 3 No. 3 (2016)
Publisher : IPB University

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Toxicity Extract and Faction of Surian Toona sinensis Leaf and Bark against Shrimp Larvae Artemia salina L. Rori Theresia; Syamsul Falah; Mega Safithri; Muhammad Assyar
Current Biochemistry Vol. 3 No. 3 (2016)
Publisher : IPB University

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Abstract

Surian (Toona sinensis) is one of the herbs that contain many bioactive compounds. Part of surian plants that can be utilized as therapy is leaf and bark. This study aims to determine the toxicity of leaf and bark extract of Surian through Bhrine Shrimp Lethality Test (BSLT), then compare toxic concentration of water extract, and ethanol 70 %, and n-hexane, diethyl ether and ethyl acetate fractions to shrimp larvae (Artemia salina L). The results showed that water content of leaves simplicia was 8.08 % and bark was 6.26 %. The highest extract rendement value by ethanol solvent was 23 %. The result of BSLT test probit analysis showed that the extract of ethyl acetate bark fraction had the highest toxicity with LC50 value 405.641 ppm, while leaf water extract had the lowest toxicity with LC50 value 707.787 ppm.
Antioxidant Activity, Inhibition α-Glucosidase of Ethanol Extract of Strychnos nitida G. Don and Identification of Active Compounds Stefani Dhale Rale; Hasim Hasim; Syamsul Falah
Current Biochemistry Vol. 5 No. 3 (2018)
Publisher : IPB University

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This study aims to find the treatment of diabetes using natural materials by exploring plants in the province of East Nusa Tenggara. his research was conducted out by extracting the Strychnos nitida G.Don stem using a method of maceration by ethanol 70%. Ethanol extract was then fractionated using n-hexane and ethyl acetate. Simplicia from maceration and fractionation results were then tested for antioxidant activity, α-glucosidase inhibition activity and identification of active compounds. The results showed that ethyl acetate fraction had the lowest IC50 value of 86.83 μg / ml. Results of the α-glucosidase activity test showed that ethyl acetate fraction and n-heksan fraction at 900 ppm had the highest percentage of inhibition of 34.23% and 33.89%. Identification using LCMS/MS method showed that ethyl acetate fraction consist of Benzenemethamine, N, N-dioctyl- as an antioxidantcompound and compound 24-methyl-5-cholestone-hexol as an antidiabetic compound. From the results of this study, we concluded that the extract of kayu ular Strychnos nitida G.Don stem has inhibition activity toward α-glucosidase enzyme.
The Inhibitory Activity and Kinetics of α-Glucosidase by Toona sinensis Stem Bark Extracts Melati Devina Gustini Wirastuti; Syamsul Falah; Syaefudin
Current Biochemistry Vol. 9 No. 1 (2022)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.9.1.2

Abstract

Research on the potential of the Surian tree (Toona sinensis) for medicine has been carried out, especially for the leaves. However, the bark section has not been done much. This study aimed to determine the inhibitory activity of -glucosidase and IC50 extract as well as the fraction of surian bark as antidiabetic in vitro. The reflux method with water at 90oC and maceration using 70% ethanol at room temperature was carried out to obtain aqueous and ethanol extracts. Furthermore, the ethanol extract was fractionated successively using n-hexane, diethyl ether, and ethyl acetate. Phytochemical screening test showed that the aqueous extract contained flavonoids, saponins, and tannins. Meanwhile, the 70% ethanol extract and its fraction showed terpenoid content, in addition to flavonoid compounds, saponins, and tannins. The best -glucosidase inhibition was shown by 70% ethanol extract, which was 70.45 ppm followed by ethyl acetate fraction, n-hexane fraction, diethyl ether fraction, and water extract of surian bark with values of 81.96 g/mL, 98.76 g/mL, respectively. , 140.25 g/mL, and 242.85 g/mL. Kinetics of -glucosidase inhibition showed that 70% ethanol extract of surian bark inhibited through a non-competitive inhibition mechanism, characterized by a decrease in Vmax from 8.29x10-3 mM/min to 1.65x10-3 mM/min and a decrease in Km from 0.17 mM to 0.03 mM.
Co-Authors , Triadiati Achmad . Achmad Achmad Agnia Nurul Jannati Agus Setiawan Agus Wibowo Aji Winara Aji Winara Ani Sulistiyani Arif Rakhman Azmi Azhari Azmi Azhari, Azmi Brilyan Yudha Pratama Budi Martono Desi Nurafida Desriani Desriani DIMAS ANDRIANTO Dwi Endah Kusumawati Ekajayanti Kining Eneng Nurlaela Faizal, Enceng Arif Fitriana S Monisa Gumelar, Dian Rachmat Hasana, Nurul Hasim Hasim I Gusti Agung Komang Diafari Djuni Hartawan I MADE ARTIKA Jaka, Aris Tri Kapitan, Origenes Boy Khalimatus Sadiah Khodijah Khodijah L M. Alfin Agushara Bena Laita Nurjanah Laita Nurjanah, Laita Laita Nurjannah Laita Nurjannah, Laita LAKSMI AMBARSARI Latifah K Darusman Lia Kusuma Dewi Livia Rhea Alvita MARIA BINTANG Marwanto, Yoga Dwi Maulana Hasanudin Mega Safithri Melati Devina Gustini Wirastuti Moh. Wifaqul Idaini Muhammad Assyar Muhammad Duror An Nashich Mustopa Mustopa Nandang Najmudin Neneng Hasanah Ni’mah, Naily Fitrotun Noora Qotrun Nada, Noora Qotrun Novik Nurhidayat Novik Nurhidayat Novilia Eka Syafitri Nuur’Alimah, Shobiroh Pelita, Bobang Noorisnan Perkasa Arian Rahmania, Fitriani Jati Rakhman, Itmam Aulia Resti Wahyuni Resti Wahyuni Ria Candra Dewi Rini Kurniasih, Rini Rini Novita Riska Ariyanti, Riska Rori Theresia Saebani, Beni Ahmad Safira Purwanto, Ukhradiya Magharaniq Sanro Tachibana Shobiroh Nuur'Alimah Stefani Dhale Rale Sulistiyani Sulistiyani Supriyanto, Hadi Suryani Suryani Suryani Suryani Suryani Suryani Susetyo Bagas Bhaskoro Syaefudin Syaripudin, Dadang Takeshi Katayama Theresia, Rori Tien Lastini Toshisada Suzuki Umul Karimah Waras Nurcholis Wiwit Amrinola Yogi Nur Anggowo Zaki Mubarok, Zaki Zuraida Zuraida