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Journal : Jurnal Fitofarmaka Indonesia

Uji Aktivitas Antiinflamasi Teh Cang Salak Secara In Vitro Dengan Metode Stabilisasi Membran Human Red Blood Cell Burhannuddin Burhannuddin; I Wayan Karta
Jurnal Fitofarmaka Indonesia Vol 10, No 2 (2023): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v10i2.903

Abstract

The use of natural ingredients can be an alternative as an anti-inflammatory agent with lower side effects. This study aims to determine the anti-inflammatory activity of cang salak tea in vitro using the human red blood cell membrane stabilization method. Cang salak tea is made into a drink in four formulations, namely P1, P2, P3, and P4 with a volume of 200 ml each. The four formulations were tested for phytochemicals and anti-inflammatory with red blood cell membrane stabilization method using diclofenac sodium as a positive control. The percentage value of red blood cell membrane stability for each formulation was then analyzed statistically with One-Way Anova and LSD tests to see the level of difference between formulations and their effect on cell membrane stability. The formulation of cang salak tea contains phytochemical compounds such as folinol (379,094 - 430,299 mg/100g GAE), flavonoids (5,299 - 7,959 mg/100g QE), alkaloids (24,312 - 28,472 mg/100g) and has antioxidant activity with a value of 3,996 - 6,222 ppm. The highest levels of active polyphenolic compounds were found in the P2 formulation, flavonoids in the P2 formulation, and alkaloids in the P3 formulation. The highest antioxidant activity was found in cang salak tea formulation P1 which had the lowest PPM value in the IC50 test. The percentage of red blood cell membrane stability in various formulations of cang salak tea had a significant difference with the highest value in formulation P1 (112.6 %), followed by formulation P2 (102 %), P3 (100, 2 %), and P4 (99, 7%) (P≤0.05). Based on the LSD test results of cang salak tea formulations P1, P2, and P3 were significantly different from the positive control (P≤0.05). While the P4 formulation was not significantly different from the positive control (P≥0.05). Cang salak tea formulations P1, P2, P3, and P4 were able to stabilize red blood cell membranes which showed strong anti-inflammatory activity
Co-Authors Abdul Kadir Apriyani, Ni Putu Helda Silpia Arifuddin Arifuddin Arini , Ni Putu Dewi Tata Arjani, Ida Ayu Arjani, Ida Ayu Made Sri Astawa, I Made Suwasa Astini, Baik Nilawati Baiq Nada Buahana Burhannuddin Cahyati, Ulya Cokorda Dewi Widhya Hana Sundari Darmiany Dewa Ayu Ika Pramitha Dewi, Ni Made Andini Dewi, Ni Made Andini Dewi, Ni Nyoman Astika Dewi, Ni Nyoman Astika Dwija Putra, I Gusti Ngurah Era Sativa, Filsa Fahruddin Fitri Fitri Hafizzaturroyani Hari Witono hasliza, pita Heri Setiyo Bekti I Gede Sudarmanto I Gusti Ayu Sri Dhyanaputri I Nyoman Jirna, I Nyoman I Nyoman Suarta I Putu Suiraoka Irmayani, Ari Jannah, Yulizul Kartawidjajaputra, Felicia Ketut Meina Sandi Khiaraturrosida, Khiaraturrosida Lailatul Isnaini Lisnani Luh Ade Wilan Krisna Mariani Mariani mastra, nyoman Melani, Boniesta Zulandha Mochamad Choirul Hadi Nabila, Alisya Nensi, Bq. Arya Ni Luh Suriani Ni Made Ary Sarasmita Nirmala Dewi, Anak Agung Lidya Nirmala Dewi, Anak Agung Lidya Nur Habibah Nurhasanah Nurhasanah Putra, I Gusti Ngurah Dwija Putri, Baiq Khofifah Kusuma Putu Amrita Paramahita Rachmayani, Ika Rasmini, Ni Wayan Ros Meilandari, rosmeilandari Sakia, Andini Putri Sandi, Ketut Meina Sari, Ni Luh Putu Eka Kartika Sari, Pruwita Sativa, Filsa Era Selviani, Tuhfa Sudarmanto, I Gede Sukardi Sukardi Sulistiani Sulistiani, Sulistiani Sundari, Cokorda Dewi Tata Arini, Ni Putu Dewi Trisnawati, Ayu Waluyo, Untung Wati, Ni Luh Candra Wati, Ni Luh Candra Widiari, Ni Nyoman Wijaya , Satria Rusdy Wilan Krisna, Luh Ade Wildan Wildan Wilian, Sudirman Witono, Hari Wiwin Quranita Yanty, Jannah Sofi