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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Journal of Agromedicine and Medical Sciences Mutiara Medika: Jurnal Kedokteran dan Kesehatan MNJ (Malang Neurology Journal) Majalah Kedokteran Sriwijaya JPSriwijaya Biomedical Journal of Indonesia Jurnal Kesehatan Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Surya Medika Jurnal Penelitian Pendidikan IPA (JPPIPA) Syntax Literate: Jurnal Ilmiah Indonesia Acta Biochimica Indonesiana Oceana Biomedicina Journal SRIWIJAYA JOURNAL OF MEDICINE Majalah Patologi Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Medica Hospitalia Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Best Journal (Biology Education, Sains and Technology) Indonesian Journal of Global Health research Jurnal Pengabdian Masyarakat: Humanity and Medicine Bioscientia Medicina : Journal of Biomedicine and Translational Research Conferences of Medical Sciences Dies Natalis Jurnal Keperawatan Molekul: Jurnal Ilmiah Kimia
Zen Hafy
Universitas Sriwijaya
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Journal : Indonesian Journal of Global Health research

 1 
A Systematic Literature Review: PvK12 and PfK13 Gene Mutations as Markers of Resistance to Artemisin Susiwati, Susiwati; Anwar, Chairil; Hafy, Zen; Liberty, Iche Andriyani
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.6599

Abstract

P. falciparum and P. vivax are among the most dangerous types of plasmodium , as they cause morbidity and mortality. Long-term use of Anti-Malaria Drugs (OAM) causes resistance. The purpose of this study was to determine the mutation of the pvk12 and pfk13 genes as a marker of resistance to artemisinin . This study used a systematic review method that was compiled based on the Preferred Reporting Items for Systematic Reviews and Meta Analyzes (PRISMA). The article search used five databases, namely PubMed, Google Scholar, BMC, Portal Garuda and the National Library (Perpusnas) of Indonesia. The keywords and boolean operators used in the literature search were "artemisinin", "resistance", "mutation", "gen", "plasmodium falciparum", "kelch 12", "kelch 13", "PvK12" PfK13" The inclusion criteria for this study were articles published at least in 2018 (the last 5 years). The exclusion criteria were paid articles, textbooks , articles systematic literature review , articles that use languages other than English and Indonesian. The results of a systematic review use 688 articles and finished of 10 articles showed that 8 articles found that there were no mutations in the pvk12 and pfk13 genes as markers of resistance to artemisinin and 2 articles found that there were mutations in the pvk12 and pfk13 genes as markers of resistance to artemisinin.
The Role of Toll-Like Receptor-2 in the Pathogenesis of Pulmonary Tuberculosis Sudarto, Sudarto; Hafy, Zen; Saleh, Irsan; Liberty, Iche Andriyani; Ahmad, Zen; Lubis, Fadhyl Zuhry; Hu, Owen; Salutondok, Welly
Indonesian Journal of Global Health Research Vol 7 No 3 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i3.6797

Abstract

Pulmonary tuberculosis (PTB), primarily caused by Mycobacterium tuberculosis (M.tb), remains a major global health burden. Toll-like receptor 2 (TLR-2), a critical component of the innate immune system, plays a key role in the host-pathogen interaction by recognizing specific components of the mycobacterial cell wall and initiating downstream inflammatory pathways. However, the dual role of TLR-2 in both protective immunity and immune evasion by M.tb contributes to the complexity of TB pathogenesis. This study aims to investigate the role of Toll-Like Receptor-2 (TLR-2) in the pathogenesis of pulmonary tuberculosis, including its immunological mechanisms, relationships with disease severity, and the potential of TLR-2 as a diagnostic and therapeutic target. This literature review systematically analyzed molecular mechanisms involving TLR-2 signaling in pulmonary TB using peer-reviewed primary and secondary sources from experimental and clinical studies. Emphasis was placed on signal transduction (NF-κB and MAPK), cytokine profiles, antigen presentation, and the impact of TLR-2 gene polymorphisms on TB susceptibility. Activation of TLR-2 through ligands such as lipoproteins, lipoarabinomannan (LAM), and PE/PPE proteins initiates immune responses via MyD88-dependent pathways, leading to the release of proinflammatory cytokines (TNF-α, IL-6, IL-12). TLR-2 also enhances the function of macrophages and dendritic cells, promoting Th1-mediated immunity. However, chronic or excessive stimulation of TLR-2 can suppress antigen processing, promote IL-10 expression, inhibit phagolysosome fusion, and facilitate M. tb survival within host macrophages. Polymorphisms in the TLR-2 gene (e.g., rs3804099) have been associated with increased susceptibility and variable clinical outcomes in PTB. TLR-2 plays a paradoxical role in pulmonary tuberculosis by mediating both protective immunity and facilitating immune evasion by M.tb. Understanding the balance of TLR-2 signaling and genetic variation is crucial for developing immunomodulatory therapies and personalized interventions in TB management.
The Relationship Between Quantitative C-Reactive Protein (CRP) and the Number of Leukocytes and Blood Edition Rate (ESR) in Optic Neuritis Patients Ramadhayanti, Lidya; Hafy, Zen; Sari, Nurmalia Purnama
Indonesian Journal of Global Health Research Vol 6 No 3 (2024): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v6i3.3164

Abstract

Optic neuritis (ON) is a demyelinating inflammatory process that causes sudden visual impairment that can occur in one or both eyes simultaneously or successively. Optic neuritis (ON) can be caused by demyelinating diseases of the central nervous system, immune system diseases, infectious diseases, and can also be caused by inflammatory responses and vaccinations. This study aimed to determine the relationship between quantitative c-reactive protein (CRP) and leukocyte count and blood edition rate (ESR) in patients with optic neuritis. The most common pathophysiology of optic neuritis is inflammatory optic neuropathy associated with multiple sclerosis. In optic neuritis, demyelination occurs due to inflammation of the optic nerve with a lesion pathology similar to plaque in the central nervous system of someone with multiple sclerosis. There will be perivascular swelling, edema of the myelinated nerve sheath, and myelin damage. Inflammation of the retinal vascular endothelium may precede demyelination. Myelin damage is more severe than the damage found in axons. This research was conducted to determine the correlation between quantitative CRP levels and leukocyte counts and erythrocyte sedimentation rate levels in optical neuritis patients. The type of research used is quantitative research with an analytical observational research design, namely a cross-sectional approach. CRP and ESR are two commonly performed laboratory tests that may help physicians in accurately diagnosing and following many complex disease conditions. The relationship between CRP levels and leukocyte counts is to evaluate the effectiveness of treatment response.
Co-Authors A, Rafdi A, Rafdi Abdullah Fikri Abdullah Sahab Afriyana Siregar Afriyana Siregar Agnes Felicia Lubis Agnes Felicia Lubis Agustian Dwi Putra Agustian Dwi Putra Agustina Br Haloho Ahmad, Zen Amalia Amalia Anisah Nida'ul Haq Argentina, Fiva aryani, Inda astri Aulia Annisa Rizki Bastian Bastian Bayu Winata Putera Calvin Ienawi Chairil Anwar Citra Ananta Avis Citra Dewi Desi Arlindia Didit Pramudhito Dwi Handayani Dwi Handayani Dwiana Ocviyanti Dwirini Retno Gunarti Dya Anggraeni Eddy Mart Salim Eddy Mart Salim Eddy Mart Salim Eddy Mart Salim Eddy Mart Salim Eddy Mart Salim, Eddy Mart Efrieni Erial Bahar Erial Bahar Erial Bahar Erial Bahar, Erial Ernawati Sinaga Fachmi Idris Fadilah, Rizka Ferry Yusrizal Ferry Yusrizal Fitri Octaviana Fitri Octaviana Francisca Srioetami Tanoerahardjo Fransisca Srioetami Tanoerahardjo Fransisca Srioetami Tanoerahardjo Gita Dwi Prasasty Hadi Nugraha Mustofa Haekal M Handayani, Sri Hartati Harun Hudari Harun Hudari Harun, Yusril Heni Maulani Heni Pujiastuti Henny Sulastri Hermansyah Hermansyah Hu, Owen Iche Andriyani Liberty, Iche Andriyani Indra Franajayakk Inggarsih, Rara Irsan Saleh Jayawarsa, A.A. Ketut Jusak Nugraha Jusuf Fantoni Kemas Ya'kub Rahadiyanto Kemas Ya'kub Rahadiyanto Kemas Ya’kub Rahadiyanto Kemas Yusuf Effendi Kms Yusuf Effendi Kms. Yusuf Effendi Kms. Yusuf Effendi Kms. Yusuf Effendi Kms. Yusuf Effendi Kodrati, Adika Krisna Murti Krisna Murti kurniati, nova Laida Neti Mulyani Larasati, Veny Legiran Legiran Legiran Legiran Lubis, Fadhyl Zuhry M, Haekal M, Haekal M. Irsan Saleh Masagus Irsan Saleh Hasani Maya Eka Apriyanti Meiliza Indriani Mgs. Irsan Saleh Mgs. Irsan Saleh Mohamad Sadikin Muhammad Irsan Saleh Nita Hertati Nova Kurniati Nova Kurniati Nova Kurniati Nova Kurniati Nova Kurniati Nova Lestari Novizar S Ocktariyana, Ocktariyana Oktariana, Desi Pancarani, Muftia Phey Liana Prihantika S., Sabrina Purnamasari, Septi Puspita, Riana Sari Puspita, Riana Sari R, Sentani R, Sentani Radiyati Umi Partan Radiyati Umi Partan, Radiyati Umi Rafdi A Rafika Novianti Rahadiyanto, Kemas Ya'Kub Rahmi Widiyawati Ramadhayanti, Lidya Ramzi Amin, Ramzi Rasyid, Riana Sari Puspita Ray Suga Aulia Ray Suga Aulia Sentani Riana Sari Puspita Riana Sari Puspita Rasyid Rikka Wijaya Rini Nindela Rini Nindela, Rini Rizal Sanif S, Novizar S, Novizar Sabri Prihantika Sabrina Prihantika Saleh, M Irsan Saleh, Mgs. M. Irsan Salutondok, Welly Sari, Nurmalia Purnama selly marisdina Selvy Apriani Sentani R SEPTI WULANDARI Soilia Fertilita Sri Handayani Sri Sulpha Siregar Sri Sulpha Siregar Subandrate Sudarto Sudarto Suly Auline Rusminan Susiwati, Susiwati Syifa Alkaf Tanoerahardjo, Francisca Srioetami Tungki Pratama Umar Venny Larasati Venny Larasati Verli Saniba Wresnindyatsih Ya’kub Rahadiyanto Yudianita Kesuma, Yudianita Yunni Diansari Yusuf Effendi Yusuf Effendi Yusuf Effendi Yusuf Effendi Zen Ahmad Ziske Maritska Zulkarnain Musa