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All Journal Majalah Kedokteran Bandung Indonesian Journal of Urology Folia Medica Indonesiana Indonesian Journal of Cancer JBN (Jurnal Bedah Nasional)
Sunaryo Hardjowijoto
Department Of Urology, Faculty Of Medicine, Universitas Airlangga/ Dr. Soetomo General Academic Hospital, Surabaya
Health Professions Medicine & Pharmacology Public Health Other

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Journal : JBN (Jurnal Bedah Nasional)

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Testicular Seminoma: Correlation Between Staging and Chemotherapy Response, Two Years Overall Survival Rate Ida Bagus Putra Pramana; Lukman Hakim; Wahjoe Djatisoesanto; Sunaryo Hardjowijoto
JBN (Jurnal Bedah Nasional) Vol 3 No 1 (2019): JBN (Jurnal Bedah Nasional)
Publisher : Program Studi Ilmu Bedah, Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (248.941 KB) | DOI: 10.24843/JBN.2019.v03.i01.p05

Abstract

Objective: to determine the patient’s characteristics, correlation between staging and chemotherapy response, furthermore two years overall survival rate. Methods: a retrospective analytic study was conducted. Data were obtained from medical records in January 2008 to December 2014 and analyzed using SPSS 17.0. All of correlation between staging and chemotherapy response, primary tumor staging (pT) and metastasis (M), regional lymph nodes staging (N) and metastasis (M), serum tumor marker and chemotherapy response were tested by Spearman correlation test. Two years overall survival rate was analyzed by Kaplan-Meier. Data ratio with normal distribution was tested by Paired T-test. Results: the mean age of patients were 31.03 ± 13.751 years, with seven patients (15.6%) had previous history of undescended testis. Based on TNM staging, we found that most patients had already develop into stage pT3 (46.7%), N3 (57.7%), and M0 (57.7%). A significant correlation between staging and chemotherapy response was shown with stage I of testicular seminoma had completely chemotherapy response (100%) and two years overall survival rate in stage I was 100%, whereas in metastatic seminoma (stage II and III) was 60%, with Hazard Ratio 0.63 (p=0.294; 95%CI 0.276-1.476). Conclusion: patients in early stage of testicular seminoma will give a better response to chemotherapy and will have better survival rate compared to those with metastatic seminoma.
Co-Authors A.A. Ketut Agung Cahyawan W Agung Dwi Wahyu Widodo Anak Agung Ngurah Oka Diatmika Aryati Aryati Aulia, Rifky Basuki B Purnomo, Basuki B Budiono Dimas Panca Andhika Doddy M Soebadi Doddy M. Soebadi Eddy Sunarno, Eddy Edwin Ongkorahardjo, Edwin Endang Joewarini Endi Prilansa Mahadi Fadhli Hasan Fauriski Febrian Prapiska, Fauriski Febrian Gondo Mastutik heri budiono I Wayan Yudiana I'tishom, Reny Ida Bagus Putra Pramana Johan Renaldo Juniastuti Juniastuti Kusuma, Raditya Lukman Hakim Lukman Hakim M. Andriady S. Nasution M. Asro Abdih Marta Hendry, Marta Meles, Dewa Ketut Moh. Ayodhia Soebadi Mohamad Ayodhia Soebadi Mohammad Ayodhia Soebadi Muhammad Ridha Mukti, Ade Indra Nurhadi, Pradana Purwati Purwati Purwati putri, Karinda triharyu caesari RIFKYA ULIA, RIFKYA Rizaldi, Fikri Sabilal Alif Satrya Husada, Satrya septa surya wahyudi, septa surya Septina Rahayu, Septina Soetojo Soetojo Suhartono Taat Putra Tarmono Djojodimedjo Taufik Indrawan Triyono Karmawan Sukmana Pria wahjoe djatisoesanto Wardhana, Sonny Andikha Wayan Suarsana Widjoseno Gardjito, Widjoseno Widodo J P Widodo J Pudjirahardjo Widodo J Pujiraharjo Willy Sandhika Yuanda, Rameshdo Zamroni Zamroni