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All Journal HAYATI Journal of Biosciences Journal of Medicine and Health Chimica et Natura Acta Jurnal Ilmu Kefarmasian Indonesia JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
MEILINAH HIDAYAT
Faculty Of Medicine, Universitas Kristen Maranatha, Bandung, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health

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Journal : JKKI : Jurnal Kedokteran dan Kesehatan Indonesia

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EKSTRAK KEDELAI DETAM 1, DAUN JATI BELANDA SERTA KOMBINASINYA TERHADAP BERAT BADAN DAN HISTOPATOLOGIS HEPAR TIKUS WISTAR Meilinah Hidayat; Sylvia Soeng; Roro Wahyudianingsih; Jeanny Ervie Ervie Ladi; Yonathan Ari Krisetya; Vera Elviora
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 6, No 4, (2015)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol6.Iss4.art2

Abstract

Latar Belakang Biji kedelai Detam 1 dan daun jati Belanda berefek menghambat kenaikan berat badan, akan tetapi dikhawatirkan mempengaruhi organ hepar. Tujuan penelitian Tujuan penelitian untuk mengetahui efek ekstrak etanol biji kedelai Detam 1 (EEKD), ekstrak etanol daun jati Belanda (EEJB) dan kombinasinya terhadap penghambatan kenaikan berat badan dan gambaran histopatologis hepar pada tikus Wistar yang diberi pakan tinggi lemak (PTL). Metode penelitian Penelitian merupakan eksperimental laboratorium dengan rancangan acak lengkap bersifat komparatif. Sebanyak 40 ekor tikus Wistar jantan dibagi secara acak menjadi 8 kelompok perlakuan, masing masing terdiri dari 5 ekor. Selanjutnya diberi perlakuan selama 28 hari, semua kelompok kecuali kelompok kontrol negatif (KN), tetap diberi PTL. Pada hari ke-29, seluruh tikus dikorbankan dan semua hepar tikus, kecuali kelompok Orlistat (K6), dibuat sediaan histopatologis dengan pewarnaan Haematoxylin Eosin (HE). Hasil Penghambatan kenaikan berat badan terjadi pada semua kelompok perlakuan, kelompok K3 (EEKD 10 mg : EEJB 20 mg) menunjukkan penghambatan kenaikan berat badan yang paling baik dan potensinya setara dengan kontrol positip (KP) atau Orlistat. Pada semua kelompok perlakuan (K1, K2, K3, K4 dan K5) terjadi perubahan struktur arsitektur dan inflamasi di daerah portal namun tidak menyebabkan bengkak keruh dan degenerasi lemak. Kesimpulan: Pemberian kombinasi EEKD 10 mg : EEJB 20 mg menunjukkan penghambatan kenaikan berat badan yang paling baik. EEJB sediaan tunggal menyebabkan perubahan gambaran histopatologis hepar paling buruk pada tikus Wistar jantan yang diinduksi pakan tinggi lemak. Kata kunci : kedelai Detam 1, jati Belanda, berat badan, histopatologis hepar, Tikus Wistar
Protein hydrolysate as a functional food for chronic kidney disease Meilinah Hidayat; Sijani Prahastuti; Andreanus Andaja Soemardji; Mohammad Yusuf; Khomaini Hasan
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 10, No 3, (2019)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol10.Iss3.art1

Abstract

No Abstract
Analysis of influencing factors in chronic kidney disease incidence in Indonesia Meilinah Hidayat; Fabiola Motulo; Santoso Chandra; Stephanie Andamari; Janto Sulungbudi; Ronny Lesmana
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 3, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss3.art10

Abstract

Background: The incidence of chronic kidney disease (CKD) continues to increase from year to year. There was an increase in CKD rates in the 2013 and 2018 basic health research or Riset kesehatan dasar (Riskesdas). Several provinces in Indonesia show a high incidence of CKD and require hemodialysis. As the incidence of CKD increases, it is important to investigate the influencing factors.Objective: To identify the influencing factors of CKD incidence in Indonesia.Methods: Data from 11 provinces with the highest incidence of CKD and hemodialysis were obtained from the Indonesian Ministry of Health through the Riskesdas 2018 survey. For comparison, the incidence of hemodialysis patients in 2020 at Immanuel Hospital Bandung was included in the investigation. All data were analysed using a Python software program, and a decision tree was determined. The results of the decision tree were analysed using Chi-square. Subject profiles were descriptively analysed for some Riskesdas 2018 data and medical records at Immanuel Hospital. Results: The total data from Riskesdas was 130,787 subjects, among those, there were 610 people with CKD/hemodialysis, meanwhile data of 79 people with hemodialysis were obtained from Immanuel Hospital. The odds ratios of diabetes mellitus was 4.54 (p=0.000), hypertension was 3.00 (p=0.000), salty food was 2.26 (p=0.000), waist circumference (WC) was 1.35 (p=0.025), and body mass index (BMI) was 1.06 (p=0.605). Conclusion: Diabetes, hypertension, salty foods, WC and BMI are the five most important factors influencing the incidence of CKD in Indonesia. These variables need to be managed properly to reduce the incidence of CKD.
Co-Authors Adhika, Oeij A Alfonsa Angwarmase, Alfonsa Andreanus A. Soemardji ANDREANUS A. SOEMARDJI Andreanus Andaja Soemardji Audrey, Gabriella Bertha M Purba, Bertha M Dewi Safitri DEWI SAFITRI ESTHEROLITA DEWI et al Fabiola Motulo Fen Tih Fenny Tanuwijaya, Fenny Gabriella, Janifer Hutagalung, Ricky B Janto Sulungbudi Jeanny Ervie Ervie Ladi Khomaini Hasan KHOMAINI HASAN Komang RP Wardani, Komang RP Liempapas, Cicilia Luvina, Petrisia Michael W. Kurniadi, Michael W. Mohammad Yusuf Nugraha, Adisurya Rendhy T Apreza, Rendhy T Retno Pangastuti Ronny Lesmana Roro Wahyudianingsih Santoso Chandra Selvina Christiany, Selvina Sijani Prahastuti Sijani Prahastuti Sijani Prahastuti Sijani Prahastuti SIJANI PRAHASTUTI Siti F. Rahmawati, Siti F. SITI FARAH Soemardji, Andreas A Stephanie Andamari Sylvia Soeng Sylvia Soeng Vera Elviora Vibiola Chikita, Vibiola Yonathan Ari Krisetya