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Journal : Indonesian Journal for Health Sciences (IJHS)

ALKYLATING AGENT TREATMENT IN CHILDREN WITH STEROID-RESISTANT NEPHROTIC SYNDROME IN WEST JAVA Widiasta, Ahmedz; Rachmadi, Dedi; Hilmanto, Dany
Indonesian Journal for Health Sciences Vol 9, No 1 (2025): March
Publisher : Universitas Muhammadiyah Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24269/ijhs.v9i1.8383

Abstract

Objective: to evaluate SRNS therapy in children. Steroid-resistant nephrotic syndrome (SRNS) is one of the most common causes of chronic kidney disease in children. Kidney Disease Initiative for Global Outcome (KDIGO) no longer recommends an alkylating agent (AA) as the treatment protocol for SRNS, still in some developing countries, such as Indonesia, there are some limitations in obtaining immunosuppressive agents other than AA. Method: Data were collected from the medical records of SRNS children with SRNS aged between 1 and 18 years from January 2016 to December 2021. The data included time to remission, adverse effects, and relapse-free period after receiving AA treatment based on the lesion type.  Results: Among the 369 patients enrolled from January 2016 to December 2018, 244 patients (66.12%) had remission with AA, and 125 patients experienced persistent proteinuria. Most of them had remission during the fifth to seventh cycles of intravenous AA (after 6 – 8 months). None of the patients experienced severe adverse effects of AA. Only a small proportion of patients had chronic kidney disease (CKD) stage II–V during follow-up. Conclusions: AA is still effective in treating SRNS in children, with only a few and less harmful adverse effects
ALKYLATING AGENT TREATMENT IN CHILDREN WITH STEROID-RESISTANT NEPHROTIC SYNDROME IN WEST JAVA Widiasta, Ahmedz; Rachmadi, Dedi; Hilmanto, Dany
Indonesian Journal of Health Science Vol 9 No 1 (2025): March
Publisher : Universitas Muhammadiyah Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24269/ijhs.v9i1.8383

Abstract

Objective: to evaluate SRNS therapy in children. Steroid-resistant nephrotic syndrome (SRNS) is one of the most common causes of chronic kidney disease in children. Kidney Disease Initiative for Global Outcome (KDIGO) no longer recommends an alkylating agent (AA) as the treatment protocol for SRNS, still in some developing countries, such as Indonesia, there are some limitations in obtaining immunosuppressive agents other than AA. Method: Data were collected from the medical records of SRNS children with SRNS aged between 1 and 18 years from January 2016 to December 2021. The data included time to remission, adverse effects, and relapse-free period after receiving AA treatment based on the lesion type.  Results: Among the 369 patients enrolled from January 2016 to December 2018, 244 patients (66.12%) had remission with AA, and 125 patients experienced persistent proteinuria. Most of them had remission during the fifth to seventh cycles of intravenous AA (after 6 – 8 months). None of the patients experienced severe adverse effects of AA. Only a small proportion of patients had chronic kidney disease (CKD) stage II–V during follow-up. Conclusions: AA is still effective in treating SRNS in children, with only a few and less harmful adverse effects
Co-Authors Achadiyani Achmad Fauzan, Achmad Adhi Pribadi Adi Utomo Suardi Ahmedz Widiasta Allania Hanung Putri Sekar Ningrum Andar Laura Nainggolan Ani Kusumastuti Ani Melani Maskoen Anita Deborah Anwar Aprianti, Nurul Azmi Aris Primadi Ariyati Mandiri Arva Rochmawati Ashifa, Ade Nurul Astuti Dyah Bestari Bagaskara, Danang Pangestu Gusti Balkis Fitriani Faozi Benny Muliawan Betty Agustina Boed Sinai Singadipoera Bony Lestari Budi Handono Cissy Kartasasmita Dadang Hudaya Somasetia dadang Hudaya Somasetia Dedi Rachmadi Dedi Rachmadi Dedi Rachmadi Deni Sunjaya Dewi Marhaeni Diah Herawati Dewi, Ni Wayan Eka Rahayu Dewi, Ni Wayan Eka Rahayu Dewi, Sawitri Dian Marta Sari Diana Rosifah Dida A Gurnida Dida A. Gurnida Dida Gurnida Dwi Agustian Dwi Agustian Dwi Prasetyo Dzulfikar Djalil Lukmanul Hakim Eddy Fadlyana Eky Setiawan Soeria Soemantri Elsa Pudji Setiawati Elsa Pudji Setiawati Elsa Pudji Setiawati Endah Purnawati Endang Sutedja Endang Sutedja Endang Sutedja Esti Hitatami Esti Istiqomah Evicenna Naftuchah Riani, Evicenna Naftuchah Fardila Elba Fardila Elba Farid Husin Farid Husin Farid Husin Firman Fuad Wirakusumah Fitria Fitria Fitria Prabandari Fitriah, Iin Prima Gaga Irawan Nugraha Gizella Gizella Gizella, Gizella Gusti Ayu Pramita aswitami Gustomo Panantro Guswan Wiwaha Hadyana Sukandar Hadyana Sukandar Hardisiswo Soedjana Hasan Purwana Hassan, Hafizah Che Henni Djuhaeni Henny Marina Henny Marina - Herman Susanto Herman Susanto Herman, Herry Husnida, Nintinjri I Made Jawi Ike MP Siregar Imelda M.G Sianipar Indah Yulika Indra Sandinirwan Indria Astuti Intan Karlina Irvan Afriandi Ishak Abdulhak James Thimoty Johanes C Mose Johanes C. Mose Julistio Tb Djais Julistio TB Djais - Kurniaty Ulfah Kurniawati Kurniawati Lestari, Lara Santi Indah Lisa Hasibuan Lisbeth Maria Laurentia Lisbeth Maria Laurentia, Lisbeth Maria Luh Nik Armini Marietta Shanti Mastiur Julianti Merry Wijaya Moudy Emma Unaria Djami Muhammad Ifan Romli Muhammad Ilham Muttaqin Muhammad Nurhalim Shahib Muttaqin, Muhammad Ilham Nanan Sekarwana Nasroen, Saskia Lenggogeni Neneng Syarifah Syafei Neneng Syarifah Syafei, Neneng Syarifah Nita Arisanti Nita Arisanti Nita Arisanti Noormartany Noormartany Noormartany Nopi Anggista Putri Nur hasanah Nurhalim Shahib Nurhasanah Nurhasanah Nurihsan, Achmad Juntika Oki Suwarsa Panantro, Gustomo Ponpon Ijradinata Ponpon S Idjradinata Pratiwi, Erlina Lutfiayu Prima Nanda Fauziah Putra Haqiqie Adnantama Lubis Qorinah Estiningtyas Sakilah Adnani Raden Tina Dewi Judistiani Rahadi, Raden Aswin Rahmah, Hasni Ratnasari, Eka Ridha Mustika Zaif Ridha Mustika Zaif, Ridha Mustika Rosalinna Rosalinna Ruswana Anwar Sari Puspa Dewi Setiawan Setiawan Setyorini Irianti Sri Endah Rahayuningsih Sri Endah Rahayuningsih Sri Sudarwati Suri, Mulhamatus Latifatus Susi Susanah Susiarno, Hadi Sutriningsih Syahdony, Farrel Nolan Syahradian Hasbrima Tetty Yuniati Tetty Yuniati Tetty Yuniati Tina Judistiani Tita Husnitawati Madjid8 Tita Madjid Tri Hanggono Achmad Ulfi Ainun Hanifah Ulfi Ainun Hanifah, Ulfi Ainun Umar, Nur Syazana Veranita Pandia Vita Murniati Tarawan Vita Murniati Tarawan Wahidah Sukriani Welli Hamik Wenny Friska Wilis Dwi Pangesti Wiryawan Permadi Yani Dewi Suryani Yoni Syukriani Yundari, Yundari Yuni Susanti Pratiwi Yuni Susanti Pratiwi, Yuni Susanti Zulvayanti Zulvayanti