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All Journal Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Dentino: Jurnal Kedokteran Gigi Dental Journal (Majalah Kedokteran Gigi) Jurnal Kedokteran Gigi Universitas Padjadjaran Jurnal Sistem Kesehatan Padjadjaran Journal of Dentistry Jurnal Kesehatan Tambusai Jurnal EduHealth
Anggun Rafisa
Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Veterinary

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Potential Protein Receptors in Enterococcus faecalis as Antibacterial and Anti-Biofilm Target Therapy in Endodontic treatment: A Review kuswandani, Faisal; Balafif, Felisha; Najmi, Nuroh; Rafisa, Anggun
Jurnal EduHealth Vol. 16 No. 03 (2025): Jurnal EduHealt, Edition July - September , 2025
Publisher : Sean Institute

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E. Faecalis  is responsible for 80−90% of hospital-acquired enterococcal infections and failed endodontic tretment. The emergence of E. Faecalis  multidrug resistance including to common endodontic medication and its ability to form biofilms have significantly complicated its clinical management. Thereby the development of novel antibacterial and antibiofilm agents is essential. Identifying and targeting key proteins is critical for drug discovery and development. This review aims to provide a brief information about potential protein receptors in E. Faecalis  that could serve as targets for antibacterial and antibiofilm therapies.
Dental Biofilm Formation: A Scoping Review Febriane Balafif, Felisha; Anggun Rafisa; Faisal Kuswandani; Nuroh Najmi
Jurnal EduHealth Vol. 16 No. 03 (2025): Jurnal EduHealt, Edition July - September , 2025
Publisher : Sean Institute

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Dental biofilm is a structured microbial community that adheres to the tooth surface and becomes embedded within a self-produced extracellular matrix. This matrix, rich in polysaccharides, proteins, and nucleic acids, enables microorganisms to survive environmental stresses and contributes to the onset of oral diseases such as caries and periodontitis. The purpose of this scoping review is to determine current knowledge the dental biofilm formation. The articles published from 2020 until 2025 were searched for using the keywords: "dental and biofilm and formation" in the PubMed, ScienceDirect, and Google scholar databases. Using PRISMA-Scr, existing articles were chosen based on inclusion and exclusion criteria. There were five articles found that were suitable for review. The data presented in the article vary according to the study's location, purpose, method, and samples. The major classes of extracellular polymeric substances that form the matrix are common to most biofilms and comprise carbohydrates, proteins, nucleic acids, and cell wall polymers, such as peptidoglycans and lipids. Several unique resistance mechanisms make biofilms particularly tough to manage. Biofilm bacteria employ multiple defense mechanisms, such as capsule protection, efflux pumps, membrane modifications, genetic adaptations, quorum sensing, metabolic dormancy, and stress responses, making them highly resistant to treatment and contributing to persistent infections.
Effectiveness of Vitamin C Supplementation in Periodontal Therapy Rafisa, Anggun; Sovira, Gita Dwi Jiwanda
Jurnal EduHealth Vol. 16 No. 03 (2025): Jurnal EduHealt, Edition July - September , 2025
Publisher : Sean Institute

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Periodontal disease is a chronic inflammatory condition initiated by microbial dysbiosis and driven by host immune responses, notably the overproduction of reactive oxygen species (ROS), which contribute to tissue damage. Vitamin C (ascorbic acid), a potent antioxidant, plays a role in collagen synthesis and immune regulation. Several studies have proposed vitamin C as an adjunct in periodontal therapy, yet its effectiveness remains unclear. This systematic review aims to evaluate the effect of vitamin C supplementation on clinical periodontal parameters in patients with periodontal disease. A comprehensive literature search was conducted in PubMed and Scopus for randomized controlled trials (RCTs) published between January 2015 and June 2025. Included studies investigated vitamin C supplementation in patients with periodontal disease without systemic conditions, pregnancy, lactation, or medication use. Studies involving vitamin C in combination with other nutrients without a separate vitamin C-only group were excluded. Data extraction and analysis followed the PRISMA guidelines. Four RCTs met the inclusion criteria. Significant clinical improvements were observed in periodontal parameters following non-surgical periodontal therapy (NSPT). However, the addition of vitamin C supplementation alone did not consistently provide significant improvements beyond NSPT alone. One study showed greater improvements when vitamin C was combined with melatonin, and another suggested potential benefits from guava—a natural source of vitamin C and polyphenols—over synthetic vitamin C. Current evidence suggests that while vitamin C supplementation may offer modest anti-inflammatory and antioxidant benefits, it does not consistently enhance clinical outcomes in periodontal therapy when used alone.
Non-Invasive Immunological Monitoring Using Saliva in Dental and Oral Health Research Najmi, Nuroh; Kuswandani , Faisal; Rafisa, Anggun; Febriane Balafif, Felisa
Jurnal EduHealth Vol. 16 No. 03 (2025): Jurnal EduHealt, Edition July - September , 2025
Publisher : Sean Institute

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Saliva plays vital roles in oral and systemic health and is emerging as a valuable tool in biomedical research. It contains bioactive components such as cytokines, enzymes, and immunoglobulins that reflect immune status, making it a promising non-invasive diagnostic fluid. A literature review was conducted using PubMed and Google Scholar Science Direct (2015–2025) with keywords related to saliva, immunological markers, and oral health. Studies included were original research on human subjects. Articles were screened following PRISMA guidelines. Salivary biomarkers such as IL-6, TNF-α, IL-17A/F, IFN-γ, CRP, calprotectin, IP-10, MCP-1, NT-proBNP, IL-1β, IL-2, IL-8, and sTNFRII have been linked to oral cancer, periodontitis, diabetes, autoimmune disorders, cardiovascular disease, and viral infections. Studies showed that these markers reflect both local inflammation and systemic immune responses. Saliva captures immune activity through pathways like Th17, TNF, and JAK/STAT signaling. Its non-invasive nature, molecular stability, and compatibility with modern analysis techniques (e.g., transcriptomics and proteomics) make it ideal for monitoring disease progression and immune function. The presence of stable biomarkers like cytokines, acute-phase proteins, and cardiovascular indicators in saliva supports its diagnostic relevance.Saliva offers a practical, non-invasive approach to immunological monitoring. With proven biomarkers for various diseases, it holds strong potential for future diagnostic and research applications.
Co-Authors Ahmad Yani ahmad yani Asty Samiaty Setiawan, Asty Samiaty Balafif, Felisa Febriane Balafif, Felisha Balafif, Felisha Febriane Chandra, Angievel Cucu Zubaedah Cucu Zubaedah Dewi Marhaeni Diah Herawati Fairuz, Anargya Alfa Faisal Kuswandani Faisal Kuswandani Falisha Febriane Balafif Farhani, Dahlia Salsa Febriane Balafif, Felisa Febriane Balafif, Felisha Felisha Febriane Balafif Gilang Yubiliana, Gilang Gita Dwi Jiwanda Sovira Kuswandani , Faisal Mochammad Rodian Nabila Anisha Nani Murniati Nuroh Najmi Nuroh Najmi Nuroh Najmi Rasmi Rikmasari Rosita Aisyah Sri Tjahajawati Sri Tjahajawati Sri Tjahajawati Sri Tjahajawati, Sri