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All Journal Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Pharmaceutical Science and Technology INDONESIAN JOURNAL OF PHARMACY Acta Pharmaciae Indonesia : Acta Pharm Indo JSFK (Jurnal Sains Farmasi & Klinis) Mandala of Health : A Scientific Journal Jurnal Tumbuhan Obat Indonesia Jurnal Sains dan Kesehatan
Tuti Sri Suhesti
Jurusan Farmasi, Fakultas Ilmu-Ilmu Kesehatan, Universitas Jenderal Soedirman
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Journal : Acta Pharmaciae Indonesia : Acta Pharm Indo

 1 
Identifikasi Interaksi Obat Pada Pasien Stroke di Unit Stroke Rumah Sakit Umum Daerah Banyumas SUHESTI, TUTI SRI; UTAMI, ESTI DYAH
Acta Pharmaciae Indonesia Vol 4 No 1 (2016)
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (215.907 KB)

Abstract

Pasien stroke sering memperoleh lebih dari dua macam obat sehingga meningkatkan kemungkinan terjadinya interaksi obat. Penelitian ini bertujuan untuk mengetahui kejadian interaksi obat pada pasien stroke rawat inap di unit stroke RSUD Banyumas berdasarkan buku Drug Interaction Facts. Penelitian ini merupakan penelitian deskriptif evaluatif yang bersifat retrospektif. Pengambilan sampel dilakukan secara total sampling. Data dianalisis secara deskriptif dan disajikan dalam bentuk data kuantitatif dan kualitatif. Hasil penelitian menunjukkan bahwa dari 62 pasien stroke terdapat 26% pasien yang mengalami interaksi obat. Jumlah interaksi obat yang paling banyak terjadi adalah 1 jenis interaksi obat (74%). Jenis interaksi obat yang sering terjadi pada pasien stroke yaitu interaksi obat antara Angiotensin Converting Enzyme Inhibitor (ACEI) dengan KCl sebanyak 18,18%. Mekanisme interaksi obat yang paling banyak terjadi adalah unknown (36%). Tingkat signifikansi 4 paling banyak terjadi yaitu 50%, dengan onset interaksi obat adalah delayed (57%) dan tingkat keparahan moderate yaitu sebanyak 57%. Dokumentasi interaksi obat yang paling banyak terjadi adalah possible (50%).
Disolusi Terbanding Tablet Acetaminophen Produk Generik Berlogo dan Produk Bermerek Suhesti, Tuti Sri; Nur Rachmani, EKA Prasasti
Acta Pharmaciae Indonesia Vol 6 No 2 (2018): Acta Pharmaciae Indonesia Volume 6 No.2 Tahun 2018
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto

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Abstract

Acetaminophen/parasetamol adalah obat analgetik-antipiretik yang populer dan banyak digunakan. Sediaan acetaminophen dalam bentuk tablet, selain dengan nama generik juga tersedia dengan nama dagang. Tujuan penelitian ini adalah untuk mengetahui ekivalensi in vitro terhadap mutu produk dagang dan generik berlogo tablet acetaminophen yang beredar di pasaran. Pada penelitian ini dilakukan uji disolusi terbanding acetaminophen produk obat generik berlogo dan produk bermerek dalam media disolusi berupa larutan dapar phosphat pH 5,8. Penentuan laju disolusi acetaminophen dilakukan menggunakan metode paddle (dayung) dengan kecepatan pengadukan 50 rpm, pada suhu 370C ± 0,50C. Sampel cuplikan diambil pada menit ke 5, 10, 15, 20, 30 dan 45. Parameter uji yang diamati adalah kadar obat terlarut pada saat t=30 menit (C30) dengan parameter standar baku C30 menunjukkan hasil tidak boleh kurang dari 80% kadar obat. Hasil penelitian didapatkan bahwa disolusi tablet acetaminophen masing-masing produk baik obat generik berlogo maupun produk bermerek menunjukkan gambaran profil disolusi yang berbeda. Dari 8 sampel diperoleh 5 produk paten dan 3 produk generik semuanya menunjukkan hasil disolusi dengan nilai C30 yang memenuhi syarat (>80)
Optimizing effervescent granules of blue pea (Clitoria ternatea L) flower ethanol extract as antioxidant Tuti Sri Suhesti; Warsinah Warsinah; Pitra Wulandari
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 10 No 1 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.1.5803

Abstract

Background: Blue pea (Clitoria ternatea) contains secondary metabolites, including flavonoids, saponins, terpenoids, tannins, and anthocyanins which have antioxidant activity. Objective: This research aims to produce the effervescent granule preparations of the blue pea flower ethanol extract with the optimal concentrations of citric acid and tartaric acid. Methods: Blue pea flower was extracted using 70% ethanol. Effervescent granules were made using the wet granulation method in eight formulas containing citric acid and tartaric acid. The physical properties of granules were evaluated, including extract quality, flow rate, dissolution time, and pH. Results: The concentration of the mixed components of citric acid 48.65 mg and tartaric acid 576.30 mg was the most optimal combination of acid sources for effervescent granules of blue pea flower extract with a desirability value of 1,000. Conclusion: The variation in the concentration of citric acid and tartaric acid affected the effervescent granule preparation's flow rate, dissolution time, and pH.
Identifikasi Interaksi Obat Pada Pasien Stroke di Unit Stroke Rumah Sakit Umum Daerah Banyumas Nurmahmudah, Nurmahmudah; Suhesti, Tuti Sri; Utami, Esti Dyah
Acta Pharmaciae Indonesia Vol 4 No 1 (2016): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pasien stroke sering memperoleh lebih dari dua macam obat sehingga meningkatkan kemungkinan terjadinya interaksi obat. Penelitian ini bertujuan untuk mengetahui kejadian interaksi obat pada pasien stroke rawat inap di unit stroke RSUD Banyumas berdasarkan buku Drug Interaction Facts. Penelitian ini merupakan penelitian deskriptif evaluatif yang bersifat retrospektif. Pengambilan sampel dilakukan secara total sampling. Data dianalisis secara deskriptif dan disajikan dalam bentuk data kuantitatif dan kualitatif. Hasil penelitian menunjukkan bahwa dari 62 pasien stroke terdapat 26% pasien yang mengalami interaksi obat. Jumlah interaksi obat yang paling banyak terjadi adalah 1 jenis interaksi obat (74%). Jenis interaksi obat yang sering terjadi pada pasien stroke yaitu interaksi obat antara Angiotensin Converting Enzyme Inhibitor (ACEI) dengan KCl sebanyak 18,18%. Mekanisme interaksi obat yang paling banyak terjadi adalah unknown (36%). Tingkat signifikansi 4 paling banyak terjadi yaitu 50%, dengan onset interaksi obat adalah delayed (57%) dan tingkat keparahan moderate yaitu sebanyak 57%. Dokumentasi interaksi obat yang paling banyak terjadi adalah possible (50%).
Optimizing effervescent granules of butterfly pea (Clitoria ternatea L) flower ethanol extract as antioxidant Suhesti, Tuti Sri; Warsinah, Warsinah; Wulandari, Pitra
Acta Pharmaciae Indonesia Vol 10 No 1 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.1.5803

Abstract

Background: Butterfly pea (Clitoria ternatea) contains secondary metabolites, including flavonoids, saponins, terpenoids, tannins, and anthocyanins which have antioxidant activity. Objective: This research aims to produce the effervescent granule preparations of the butterfly pea flower ethanol extract with the optimal concentrations of citric acid and tartaric acid. Methods: Butterfly pea flower was extracted using 70% ethanol. Effervescent granules were made using the wet granulation method in eight formulas containing citric acid and tartaric acid. The physical properties of granules were evaluated, including extract quality, flow rate, dissolution time, and pH. Results: The concentration of the mixed components of citric acid 48.65 mg and tartaric acid 576.30 mg was the most optimal combination of acid sources for effervescent granules of butterfly pea flower extract with a desirability value of 1,000. Conclusion: The variation in the concentration of citric acid and tartaric acid affected flow rate, dissolution time, and pH of the effervescent granule preparation.
Antioxidant activity of ethanol extract and ethyl acetate fraction of blue pea flower (Clitoria ternatea L.) Suhesti, Tuti Sri; Rahmahwati, Devita Sukma; Warsinah, Warsinah; Nuryanti, Nuryanti; Utami, Vitis Vini Vera Ratna
Acta Pharmaciae Indonesia Vol 12 No 2 (2024): Acta Pharmaciae Indonesia: Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2024.12.2.12636

Abstract

Background: The imbalance of free radicals can be mitigated by antioxidants. Natural sources, such as the blue pea flower (Clitoria ternatea L.), have gained attention as potential antioxidant alternatives. Objective: This study aimed to evaluate the antioxidant potential of the blue pea flower by extracting its fractions using n-hexane and ethyl acetate. Methods: The study employed an experimental design involving maceration for extraction, followed by fractionation using n-hexane and ethyl acetate solvents. Antioxidant activity was assessed using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. Data from both qualitative identification and antioxidant tests were analyzed descriptively and quantitatively to determine the IC50 values. Results: The analysis revealed that both the extracts and fractions of the blue pea flower contain bioactive compounds with antioxidant potential, including flavonoids, tannins, steroids, and terpenoids. The IC50 values for antioxidant activity were as follows: n-hexane fraction, 85.28 µg/mL; ethyl acetate fraction, 82.94 µg/mL; and ethanol fraction, 78.78 µg/mL. Conclusion: Flavonoids, steroids, and terpenoids were identified in both the blue pea flower extract and ethyl acetate fraction, while tannins were present only in the ethanol extract. Strong antioxidant activity was observed in all fractions, including the ethanol extract, n-hexane, and ethyl acetate fractions.
Co-Authors A Haris Budi Widodo Achmad Fudholi Amatullah Syarifah Amilia Ramadhani Arifa Aldi, Nisa Ario Ditto Primandaru Christiana Cahyani Prihastuti Diani Mentari Eka Prasasti Nur Rachmani Esti Dyah Utami Fanni Kusuma Djati M. Mudrik H. Rohman Muhammad, Katon Muslimah, Annisa Ni Ken Ritchie, Ni Ken Nurmahmudah, Nurmahmudah Nurmahmudah, Nurmahmudah Nurpratami, Diah Nuryanti Nuryanti Pitra Wulandari Rahmahwati, Devita Sukma Rehana Rinawati Satrio Sunarto Sunarto Utami, Vitis Vini Vera Ratna Warsinah Warsinah Warsinah Warsinah Wijayanti, Gratiana Ekaningsih Wulandari, Pitra