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All Journal Indonesian Journal of Pharmaceutical Science and Technology Gema Pendidikan Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Jurnal Sains dan Teknologi Pangan Jurnal Penelitian Pendidikan IPA (JPPIPA) Preventif Journal Jurnal Mandala Pharmacon Indonesia Journal Borneo Jurnal Gizi dan Kesehatan Indonesia Jurnal Farmasi Sains dan Praktis Jurnal Pengabdian Nusantara (JPN) MOSIRAHA : Jurnal Pengabdian Farmasi Lansau: Jurnal Ilmu Kefarmasian Jurnal Abdi dan Dedikasi kepada Masyarakat Indonesia Parapemikir Jurnal Ilmiah Farmasi Jurnal Pengabdian Masyarakat Panacea Borneo Journal of Pharmacy Kartika : Jurnal Ilmiah Farmasi Medical Sains : Jurnal Ilmiah Kefarmasian Mammiri: Jurnal Pengabdian Masyarakat Jurnal Sains dan Kesehatan
Kasmawati, Henny
Department Of Pharmacology, Faculty Of Pharmacy, Universitas Halu Oleo
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : Indonesian Journal of Pharmaceutical Science and Technology

 1 
Activity Assay of Etanol Ectract of Lansau As Antihyperlipidemic Ruslin Ruslin; Henny Kasmawati; Suriani Suriani; Sundar Ihsan; Desi Sartina
Indonesian Journal of Pharmaceutical Science and Technology Vol 6, No 3 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v6i3.21611

Abstract

Hyperlipidemia is a condition due to increased levels of total cholesterol such as triglycerides, Low Density Lipoprotein (LDL) and decreased levels of High Density Lipoprotein (HDL). Hyperlipidemia can trigger wall thickening and narrowing of arteries, this condition can cause abnormality of fat metabolism in the blood and creates chronic disease. Lansau herb of the Muna tribe of Southeast Sulawesi consists of 44 ingredients of medicinal plants empirically used to treat various diseases such as koleseterol. The aim of this study was to determine the effect of ethanolic extract to the hispatology of the liver that had hyperlipidemia. The parameters are fatty cell and necrosis forming. Mice were induced by cholesterol and high-fat feed. 24 wistar rats were divided into 6 groups consisting of normal control (1% Na CMC), cholesterol and high fat diet food induction control, positive control (simvastatin 0.4 mg / kgbw), group 1 (dose 6.907 mg / kgbw) group II (dose 13.814 mg /kgbw), group III (dose 27.628 mg/kgbw). After 14 days of treatment, hispatological datas  of liver were observed. The results showed that the ethanol extract of lansau had the potential activity as antihyperlipidemia, and cell repairing, especially in administering doses of 27.628 mg/kgbw and had effectiveness that was not much different from the administration of simvastatin in reducing fat degeneration and cell death.Key word : Aterosclerosis, hyperlipidemic, Lansau, simvastatin. 
Sansevieria trifasciata Prain. : A Review on Its Phytochemicals and Pharmacological Potential Sida, Nurramadhani A; Kasmawati, Henny; Ruslin, Ruslin
Indonesian Journal of Pharmaceutical Science and Technology 2024: Suppl. 6, No. 2 (Universitas Halu Uleo Conference)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v6i2.52626

Abstract

Sansevieria trifasciata Prain is known to contain phytochemical compounds and has the potential to treat various diseases. A systematic review was conducted by searching articles on Google Scholar, PubMed, NCBI, and Science Direct to gather information on identified chemical compounds and the pharmacological test results of S. trifasciata Prain leaves, both in vitro, in vivo, and in silico. The result showed that phytochemicals were derivatives of the flavonoids, alkaloids, steroids, saponins, glycosides, polyphenols, and fatty acids groups. These phytochemicals exhibit pharmacological properties, including antidiabetic, antibacterial, anticancer, antihelminthic, antimalarial, antifungal, antioxidant, antiwound healing, antianalgesic, and antiallergic properties. Acute toxicity tests indicate that S. trifasciata Prain. is safe for use, with an LC50 value exceeding 2000 mg/kgBW. We can conclude that Sansevieria trifasciataPrain. is a potential herb as medicine to treat various diseases based on its chemical compounds.Sansevieria trifasciata Prain is known to contain phytochemical compounds and has the potential to treat various diseases. A systematic review was conducted by searching articles on Google Scholar, PubMed, NCBI, and Science Direct to gather information on identified chemical compounds and the pharmacological test results of S. trifasciata Prain leaves, both in vitro, in vivo, and in silico. The result showed that phytochemicals were derivatives of the flavonoids, alkaloids, steroids, saponins, glycosides, polyphenols, and fatty acids groups. These phytochemicals exhibit pharmacological properties, including antidiabetic, antibacterial, anticancer, antihelminthic, antimalarial, antifungal, antioxidant, antiwound healing, antianalgesic, and antiallergic properties. Acute toxicity tests indicate that S. trifasciata Prain. is safe for use, with an LC50 value exceeding 2000 mg/kgBW. We can conclude that Sansevieria trifasciata Prain. is a potential herb as medicine to treat various diseases based on its chemical compounds.
Rigid and Flexible Docking Study with ADME Evaluation of Hesperetin Analogues as LecB Inhibitors in Pseudomonas aeruginosa Arfan, Arfan; Rayani, Nur; Ruslin, Ruslin; Kasmawati, Henny; Aman, La Ode; Asnawi, Aiyi
Indonesian Journal of Pharmaceutical Science and Technology 2024: Suppl. 6, No. 2 (Universitas Halu Uleo Conference)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v6i2.52623

Abstract

Infections caused by Pseudomonas aeruginosa pose a considerable challenge in terms of treatment. The bacterium's key virulence factor, particularly LecB, plays a significant role in bacterial adherence, infections, biofilm formation, and suppression of the host immune response. This study aims to assess the affinity and interactions of hesperetin analogs against LecB in P. aeruginosa. The investigation utilized the molecular docking method, employing a combination of rigid and flexible docking. The docking results successfully identified hesperetin 7-O-glucoside and hesperetin 7-O-rhamnoside, demonstrating superior binding energies compared to MJO as the reference ligand. Rigid docking indicated binding energies of -7.0 and -7.2 kcal/mol for hesperetin 7-O-glucoside and hesperetin 7-O-rhamnoside, respectively. Subsequently, flexible docking revealed lower binding energies for both compounds, reaching -10.3 kcal/mol. These top-performing compounds exhibited interactions with critical residues, including Asn70, Arg72, Thr98, Asp99, Asp96, Asn21, and Ser23, strategically positioned in LecB's substrate-binding site in P. aeruginosa. Notably, hesperetin 7-O-rhamnoside displayed an excellent ADME profile and a favorable safety profile, as it was predicted not to inhibit CYP enzymes. The hesperetin analog also met Lipinski's rules, suggesting its suitability as an oral drug. In conclusion, this research unveils the potential antibacterial activity of hesperetin analogs and provides an opportunity for experimental verification of these compounds as candidates for antibacterial drugs against P. aeruginosa.
Co-Authors ,, Suryani A.A. Ketut Agung Cahyawan W Abd Rafid Achmad Fuad Hafid Aiyi Asnawi Aiyi Asnawi Alfad Fadri Alfian Alfian Anjani, Ratna Arfan Arfan Arfan Arfan Ariani, Eno Retno Armadani, Fery Indradewi Aspadiah, Vica Aswani Aswani Aswani Aswani Aswani Aswani Aswani Aswani Aty Widyawaruyanti Damu, Rusliati Desi Sartina Dian Munasari Solo Eka Pebriana Eka, Bau Mirna Ayu Fery Indradewi Fery Indradewi Armadany Fifi Nirmala Firawati Fitrawan, La Ode Muhammad Fitri Rahmadani Saputri Fitriyanti J. Sami Fitriyanti Jumaetri Sami Fristiohady, Adryan Halik Halik Hasnawati Hasnawati Hasniar, Wa Ode Irvan Anwar Jamil, Siti Amaliah Jamsir, Asmaidah La Ode Aman La Ode Muh. Fitrawan La Ode Muhammad Diman La Ode Muhammad Fitrawan Linggi Allo, Lisa Talita Loly Subhiaty Idrus Loly Subhiyati Idrus Madjid, Waode Istiqamah Malaka, Muhammad Hajrul Mallarangeng, Andi Nafisah Tendri Adjeng Mardiani, Siti Marwati Marwati Marwati Marwati Mesi Leorita, Mesi Muh. Arba Munarsi Munarsi Mutmainna, Mutmainna Nina Salamah Ningsih, Warda Ayu Nur Filzanah Nur Illiyyin Akib Nur Illiyyin Akib Nur Illiyyin Akib Nur Kharisma Amin Nur Rayani Nur Syam Hidayah Rahma Ismail Nuralifah Nuralifah, Nuralifah NURFAUSIAH Nurramadhani A. Sida Nurramadhani A. Sida Nursamsiar Nursamsiar Nurull Hikmah Nurull Hikmah Rahmat Muliadi Rahmayani, Nur Rayani, Nur Ridho Fajriyah Jamri Rifa’atul Mahmudah Rimala Sanipurnama Kindkasman Rini Hamsidi Ruben, Sony Ruslin Ruslin Ruslin , Ruslin Ruslin Ruslin Ruslin Ruslin Ruslin Ruslin Ruslin Ruslin, R Ruslin, Ruslin Rusman, Arman Sabarudin Sabarudin Sabarudin Sabarudin Sabarudin Sabarudin Sabarudin, S Sarmita, Sarmita Septiyana, Wanda Sida, Nurramdhani A. Siti Ruhima Sitti Raodah Nurul Jannah Soleman, Imelda Sarda Sudiman, Aswan Sunandar Ihsan Sunandar Ihsan Sunandar Ihsan Sunandar Ihsan Sunandar Ihsan, Sunandar Sundar Ihsan Sundar Ihsan Suprianti, Rani Suriani Suriani Suryani Suryani Suryani, S Syamsu Nur Tri Handayani Vica Aspadiah Vica Aspadiah W Wahyuni, W Wa Ode Dian Indrayanti Wanda Hamidah Wardana, Gede Yogi Prana Wiwied Ekasari Yamin Yamin , Yamin Yamin Yamin, Y Zubaydah, Wa Ode Sitti