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All Journal Jurnal Ilmiah Farmasi Natural Science: Journal of Science and Technology Pharmaciana: Jurnal Kefarmasian DeKaVe The Journal of Pure and Applied Chemistry Research Jurnal Farmasi Klinik Indonesia Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Scholaria: Jurnal Pendidikan dan Kebudayaan Jurnal Wiyata : Penelitian Sains dan Kesehatan CARADDE: Jurnal Pengabdian Kepada Masyarakat Jurnal Biomedika dan Kesehatan Academia Open Berkala Ilmiah Mahasiswa Farmasi Jurnal Farmasi dan Sains Indonesia (JFSI) Journal of Community Practice and Social Welfare (JaCiPS) Media Farmasi Indonesia Sainsbertek Jurnal Ilmiah Sains & Teknologi Prosiding Seminar Nasional Universitas Ma Chung Jurnal Novem Medika Farmasi Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas KOPEMAS
Martanty Aditya, Martanty
Program Studi Farmasi Fakultas Sains Dan Teknologi Universitas Ma Chung
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Other

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Journal : Jurnal Ilmiah Farmasi

 1 
The risk of Angiotensin Converting Enzyme Inhibitor (ACEI) and Calcium Channel Blocker (CCB) used on Obstructive Sleep Apnea (OSA) incidence in hypertension patients Fibe Yulinda Cesa; Martanty Aditya; Rehmadanta Sitepu; Dion Notario
Jurnal Ilmiah Farmasi 2022: Special Issue
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.specialissue2022.art1

Abstract

AbstractBackground: The administration of angiotensin-converting enzyme inhibitor (ACEI) and calcium channel blocker (CCB) therapy is known to have a side effect of a dry cough that would trigger OSA. Further research is needed to compare the effect of these two drugs on the side effects of OSA, which could trigger high-risk patient conditions.       Objective: To determine the risk of using ACE and CCB on the incidence of OSA using a case-control study method at Dau Primary Health Center.Methods: Demographic data were collected on 207 respondents aged 40-60 years by collecting Data Collection Sheets and Berlin questionnaires to determine the risk of OSA in respondents. Then, statistical analysis was carried out by determining the odds ratio (OR).Results: The results showed that one of the factors BMI (obese BMI; OR=1.33; 95% CI=0.11-15.70) induces OSA with the highest OR value compared to other factors.Conclusion: Obese patient has a 1.33 times greater risk of OSA with ACEI and CCB therapy than non-obese. It is necessary to conduct further research with a larger sample size related to OSA’s assessment associated with this therapy to improve patients’ quality of life.Keywords: Obstructive sleep apnea, ACE inhibitors, calcium channel blockers, hypertension IntisariLatar belakang: Obtructive Sleep Apnea (OSA) yang terjadi pada pasien hipertensi dapat disebabkan karena efek samping dari penggunaan antihipertensi angiotensin converting enzyme inhibitor (ACEI) dan calcium channel blocker (CCB), namun analisis hubungan keduanya belum diketahui dengan pasti.Tujuan: Penelitian ini bertujuan untuk mengetahui risiko penggunaan ACE dan CCB terhadap kejadian OSA dengan metode case control study di Puskesmas Dau.Metode: Pengambilan data demografi pada 207 responden usia 40-60 tahun dilakukan dengan mengumpulkan Lembar Pengumpul Data (LPD) dan kuesioner Berlin untuk mengetahui risiko OSA pada responden kemudian dilakukan analisis statistik dengan penentuan odds ratio (OR).Hasil: Hasil penelitian menunjukkan bahwa pasien yang menjalani pengobatan dengan antihipertensi ACEI dan obesitas memiliki risiko lebih besar mengalami OSA (OR=1,33; CI 95%=0,11-15,70)  yaitu 1,33 kali dibandingkan pada pasien yang tidak obesitas.Kesimpulan: Obesitas menjadi factor risiko terhadap kejadian OSA pada pasien hipertensi yang mendapatkan antihipertensi golongan ACEI dan CCB.Kata kunci: Obstructive sleep apnea, ACE inhibitor, calcium channel blocker, hipertensi
Evaluation of single and combination chemotherapy agents in patients with metastatic breast cancer Martanty Aditya; Godeliva Adriani Hendra; Suhul Raos Kumawula Ing Gustyas
Jurnal Ilmiah Farmasi Vol. 18 No. 2 (2022): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol18.iss2.art14

Abstract

Background: There are several ways to treat breast cancer, one of which is administering chemotherapy agents. Chemotherapy agents have activity in inhibiting the cell cycle. That will affect the effectiveness of therapy and the side effects of chemotherapy agents. Objective: This study aimed to evaluate single and combination chemotherapy agent therapeutic efficacy and side effects Method: The design of this study used an observational cohort study with retrospective data collection from January to December 2019. Patients obtained from medical records were diagnosed with metastatic stage of breast cancer at Panti Nirmala Hospital, Malang. The effectiveness of the chemotherapy agent was seen from the carcinoembryonic antigen (CEA) and cancer antigen 15-3 (CA15-3), which were carried out in the first and third cycles, then analyzed using the Wilcoxon and U-Mann Whitney tests. Side effects of chemotherapy agents were analyzed descriptively. Results: Analysis of the Wilcoxon test showed differences between the two groups of chemotherapeutic agents in CEA and CA15-3 (p<0.05). U-Mann Whitney test analysis showed no difference after administration of the two groups of chemotherapy agents at CEA (p>0.05). However, there was a difference in CA15-3 (p<0.05). Both chemotherapy agents showed most common side effects such as pain, nausea,  vomiting, and alopecia. Conclusion: Patients who received a combination of chemotherapy agents had lower CA15-3 levels than single chemotherapy agents.
Co-Authors Aftoni, Muhammad Hilmi agustin, Christina Aprilia, Devi Ratna Arif Santoso Cesa, Fibe Yulinda Chresiani Destianita Yoedistira Chresiani Destianita Yoedistira Chresiani Destianita Yoedistira Dewi Fortuna Surat Bala Dion Notario Dion Notario Ega Malia Jiska Eva Monica Eva Monica, Eva Feliadewi Ruth Feliadewi Ruth Fibe Y. Cesa Fibe Yulinda Cesa Fibe Yulinda Cesa Fibe Yulinda Cesa Fibe Yulinda Cesa Fina Noor Maghfira Godeliva Adriani Hendra Godeliva Adriani Hendra Haryanto Susanto Kestrilia Rega Prilianti Maitreya, Putera Monica, Eva Muhammad Hilmi Afthoni muliyawan, Johan Nugraha, Dhanang Prawira Nurul Najlatun Nisa Putri Devy Septya Ratu, Modestus Rehmadanta Sitepu Rehmadanta Sitepu Rehmadanta Sitepu Rehmadanta Sitepu Renaldy Kristian Yohansyah ria septiana Rinda Puspita Sari Rollando, Rollando Sabrina Handayani Tambun Salsabila Rohadatul Aisy Sintia Dina Pranata Sitepu, Rehmadanta Sri Susilowati Sri Suwarni Sri Suwarni Suhul Raos Kumawula Ing Gustyas Tegar Andito Venty Yuliasari Wulandari, A. Ratna Yeni Rahmawati Yulis Mitra Reformasika